ORGANISATION/COMPANYOspedale Pediatrico Bambino Gesù
RESEARCH FIELDBiological sciences › Biology
RESEARCHER PROFILEFirst Stage Researcher (R1)
APPLICATION DEADLINE31/05/2021 23:00 - Europe/London
LOCATIONItaly › Rome
TYPE OF CONTRACTTemporary
HOURS PER WEEK40
OFFER STARTING DATE01/10/2021
EU RESEARCH FRAMEWORK PROGRAMMEH2020 / Marie Skłodowska-Curie Actions
MARIE CURIE GRANT AGREEMENT NUMBER954992
The CAPSTONE consortium aims to develop small molecules that modulate presentation of tumour and self-antigens, as a novel immunotherapeutic approach. These molecules will target several aminopeptidases (ERAP and IRAP) that play a key role in peptide presentation by MHC class I molecules. The consortium will work to deepen our understanding of the cellular pathways implicating the enzymes, decipher enzyme dysfunction in diseases, and design and validate innovative selective therapeutic drugs. CAPSTONE will be a transdisciplinary state-of-the-art environment to train 15 Early-Stage Researchers. The consortium brings together a multidisciplinary group of researchers in medicinal chemistry, crystallography, cell biology, biomedicine, mass spectrometry, systems biology and bioinformatics, implicating academic institutions, industry and patient associations. CAPSTONE will prepare the ESRs for career perspectives in academia, the pharmaceutical industry, biotechnology SMEs, and provide them with scientific and transferable skills and high-value professional connections.
The selected candidate will study a panel of human leukaemia/lymphoma cells with functional ERAP1 to decipher the mechanism underlying the induction of NK cell-mediated anti-tumor responses resulting from ERAP1 inhibition. ERAP1 is known to regulate NK cell function by controlling the engagement of inhibitory receptors. This project will focus on generating CRISP/Cas9 ERAP KO leukaemia/lymphoma cells from patients expressing a functional ERAP gene to evaluate their ability to activate NK cells from healthy donors by functional assays. The most efficient tumor/NK cell combinations will be tested in vivo in NSG mice by adoptive transfer of NK cells and ERAP1 inhibitors. The candidate will collaborate with a fellow PhD student studying the function of ERAP aminopeptidases in the regulation of the tumor immune microenvironment.
Supervisor: Dr Doriana Fruci
Please apply through CAPSTONE website, selecting ESR#10
Full social security beneficts are provided.
Marie Curie eligibility rules requires ESRs to have at most four years of research experience. To satisfy Marie Curie mobility criteria, you must not have resided or carried out your main activity (work, studies, etc.) in Italy for more than 12 months in the 3 years prior to the start date (short stays such as holidays and/or compulsory national service are not taken into account).
REQUIRED EDUCATION LEVELBiological sciences: Master Degree or equivalent
REQUIRED LANGUAGESENGLISH: Excellent
Excellent training in immunology and molecular/cellular biology is essential. Additional training in cell imaging and in vivo biology is deisderable.
Strong motivation to work individually and as part of a team in an interdisciplinary environment, with the ability to pay close attention to detail and meet deadlines.
Ambition and strong personal interest in research.
Curiosity and independent creative thinking.
Teamwork spirit and good communication skills.
- Updated Curriculum vitae inclusive of contact details of previous supervisors. (Max 3 pages)
- Statement of interest and motivation in doing the PhD in this research field along with the description of your research skills, experience and publications and a brief description of the current expertise and the master thesis project (Max 3 page);
- Recommendation letter(s) of your previous supervisors. (Desirable).
- All applications will be handled confidentially. By submitting an application, you consent to your application being shared with the other principal investigators of the CAPSTONE consortium for the sole purpose of the candidate recruitment. Please note that only complete application sets will be considered.
EURAXESS offer ID: 607301
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