18/02/2021

Impact of new cancer therapies on cognitive functions

This job offer has expired


  • ORGANISATION/COMPANY
    INSERM
  • RESEARCH FIELD
    NeurosciencesNeuropsychology
    Psychological sciencesPsychology
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
    Recognised Researcher (R2)
  • APPLICATION DEADLINE
    31/10/2021 01:00 - Europe/Athens
  • LOCATION
    France › Caen
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    39
  • OFFER STARTING DATE
    01/09/2021

OFFER DESCRIPTION

Post-doctoral subject « Cognition and new cancer therapies »

 

Title

Impact of new cancer therapies on cognitive functions

 

Scientific fields

Clinical research, public health, neuropsychology, human and social sciences

 

Keywords

Cancer, cognition, cognitive complaints, new generation of hormone therapies, immunotherapy, proton therapy, longitudinal studies, quality of life

 

Description of the project

Diagnostic and therapeutic advances in the field of cancer have considerably increased the chances of survival and the lifespan of patients, even in metastatic situations. New modalities of radiotherapy as well as new generation hormone therapies, targeted therapies and immunotherapy treatments are currently being proposed. These treatments are often delivered over a long period of time with specific toxicity profiles. Among these side effects, cognitive difficulties, such as alterations in memory, attention, executive functions and speed of treatment, are frequently reported by patients and constitute a major issue in terms of quality of life. These symptoms have been well documented after chemotherapy (notion of "chemofog") and conventional radiotherapy (including panencephalic in the case of the central nervous system). Nevertheless, while some preliminary work suggests the impact of new cancer therapies on cognition, further studies are needed to better understand these side effects.

The programme in which the post-doctoral fellow’s work is integrated aims to evaluate the impact of new cancer therapies, and more specifically new generation hormone therapies for metastatic prostate cancer, immunotherapies and new modalities of cerebral radiotherapy (stereotactic radiotherapy/proton therapy/hadron therapy, particularly for slow-growing brain tumours), on the cognitive functions of cancer patients - corresponding to ongoing studies: Cog-Pro studies for new generation hormone therapies, Cog-Immuno for immunotherapy treatments, Cancer-Cog/Cog-Proton for innovative radiotherapy. Thus, evaluating the impact of these new cancer therapeutic strategies on cognitive functions will notably enable us to identify populations of patients at risk and offer them appropriate solutions to improve their quality of life.

 

Host Research Laboratory

Inserm U1086 Anticipe

Centre François Baclesse

Caen

https://anticipe.eu/

 

The Anticipe Unit (Inserm U1086), directed by Pr Guy LAUNOY, develops fundamental and applied research aimed at proposing strategies for the prevention or treatment of cancers that are best adapted to individuals and their environment. In daily interaction with the practitioners of the University Hospital and the François Baclesse Cancer Center, it brings together about a hundred people who develop research work structured in two areas: "Cancers and Prevention" and "Biology and Innovative Therapies for Ovarian Cancers". The "Cancers and Prevention" axis is divided into several themes, one of which (led by Prof. Florence JOLY) focuses in particular on "Quality of life and life after cancer" with a focus on the impact of cancer treatments on cognitive functions. This work is supported by the Cancer and Cognition platform (http://www.cancerandcognition.com/). This post-doctoral project will be part of the research programme of the platform.

 

 

Missions

The candidate's assignments will include :

- The coordination of ongoing longitudinal studies (Cog-Pro and Cog-Immuno) on the impact of new cancer therapies on cognition,

- The collection of data from studies currently being finalised (Cog-Pro and Cog-Immuno studies),

- The scientific valorisation of the Cog-Pro and Cog-Immuno studies,

- Participation in the implementation and follow-up of the Cog-Proton study and the valorisation of the preliminary results at the end of the post-doctorate.

This work will be carried out within the Inserm Anticipe 1086 Unit in link with the Cancer and Cognition platform, and will be done in close collaboration with the Clinical Research Department (DRCI) of the François Baclesse Center.

 

Candidate profile

Validated scientific or medical studies and PhD in public health, epidemiology, clinical research, neuropsychology etc.

 

Required skills :

- Team work

- Organization

- Dynamism

- Communication/contact with patients

- Scientific valorization (data management and analysis, critical analysis of literature, writing scientific articles, communications in conferences, etc.).

- Interest in public health research and clinical research

- Knowledge in oncology, neurosciences and quality of life will be appreciated

 

Financing and duration

Applications for funding are underway (results expected by fall 2021).

The duration of the post-doctoral fellowship will depend on the grant obtained (between 2 and 3 years).

 

How to apply

  • curriculum vitae
  • motivation letter
  • list of publications

To be sent to :

Marie Lange (neuropsychologist of the cancer and cognition platform) : m.lange@baclesse.unicancer.fr

Laure Tron (project manager of the cancer and cognition platform) : laure.tron@inserm.fr

 

More Information

Additional comments

Financing and duration

Applications for funding are underway (results expected by fall 2021).

The duration of the post-doctoral fellowship will depend on the grant obtained (between 2 and 3 years).

 

How to apply

  • curriculum vitae
  • motivation letter
  • list of publications

To be sent to :

Marie Lange (neuropsychologist of the cancer and cognition platform) : m.lange@baclesse.unicancer.fr

Laure Tron (project manager of the cancer and cognition platform) : laure.tron@inserm.fr

 

Offer Requirements

Skills/Qualifications

Validated scientific or medical studies and PhD in public health, epidemiology, clinical research, neuropsychology etc.

Specific Requirements

Required skills :

- Team work

- Organization

- Dynamism

- Communication/contact with patients

- Scientific valorization (data management and analysis, critical analysis of literature, writing scientific articles, communications in conferences, etc.).

- Interest in public health research and clinical research

- Knowledge in oncology, neurosciences and quality of life will be appreciated

Work location(s)
1 position(s) available at
U1086
France
Caen

EURAXESS offer ID: 606799

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