ORGANISATION/COMPANYInstitute of Scientific Instruments of the CAS, v. v. i.
RESEARCH FIELDPhysics › Optics
RESEARCHER PROFILEFirst Stage Researcher (R1)
APPLICATION DEADLINE30/04/2021 18:00 - Europe/Brussels
LOCATIONCzech Republic › Brno
TYPE OF CONTRACTTemporary
HOURS PER WEEK40
EU RESEARCH FRAMEWORK PROGRAMMEH2020
The methods of holographic endoscopy have recently emerged as a powerful platform to introduce sub-cellular resolution microscopy deep inside tissues of living organisms, including brain. Our laboratory of Complex Photonics (lead by Prof. Čižmár, https://www.isibrno.cz/cs/komplexni-fotonika) has been developing cutting edge multi-mode fibre based endoscopes and applying them in brain imaging in animal models in vivo. These minimally-invasive endoscopes can reach deep subcortical locations in the brain which are not accessible by other optical methods of similar resolution.
This PhD work will focus on expanding the capabilities of the system with two new modalities: optical manipulation of cells using optogenetics and extracellular electrophysiological recordings. Optogenetics is a unique tool that enables manipulation of cellular activity with light. Electrophysilogy has been a golden standard method of neuroscience for the past fifty years which allows recordings of local field potentials (LFP) and multi-unit activity (MUA) of neurons. Uniquely, these modalities will be implemented within the same thin endoscopic probe which serves for imaging. Implementation of electrophysiology will be carried out in collaboration with Prof. Massimo de Vittorio and Dr. Ferruccio Pisanello (Instituto Italiano de Technologia).
The work will be carried out at the Institute of Scientific Instruments of the Academy of Sciences of the Czech Republic with the possibility of full-time employment. We offer a competitive salary ~ 20k eur/year (gross) and additional stipend from the university. The position is funded until 12/2024. The PhD student will be a part of a European Commision project “DEEPER: Deep brain photonic tools for cell-type specific targeting of neural diseases" (https://www.deeperproject.eu/), which is funded within the European Union’s Horizon 2020 research and innovation actions scheme as is just starting at this institute. This Consortium clusters world-leading experts in molecular photonic tools, optical technology, pre-clinical, clinical brain research and innovative start-ups in an endeavour of providing new tools to tackle the mechanisms underlying the pathogenesis of neurological disease.
Please send a CV and motivation letter to firstname.lastname@example.org.
REQUIRED EDUCATION LEVELPhysics: Master Degree or equivalentEngineering: Master Degree or equivalentNeurosciences: Master Degree or equivalent
REQUIRED LANGUAGESENGLISH: Excellent
The candidate will develop/modify optical setups and the software for hardware control and data acquisition and processing (Lab View, Matlab, C++). He/she will implement the setup in brain imaging in vivo in mouse models.
Master in Physics, Optics, Engineering or Neuroscience/Neurobiology required. Knowledge and experience in programing or optical set-up building is required. Experience with microscopy, fluorescence microscopy or electrophysiology is desirable.
EURAXESS offer ID: 604587
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