14/01/2021
The Human Resources Strategy for Researchers

Postdoctoral Position in Biochemistry & Proteomics – Strasbourg-Cronenbourg site

This job offer has expired


  • ORGANISATION/COMPANY
    Université de Strasbourg
  • RESEARCH FIELD
    Biological sciences
    ChemistryBiochemistry
    Pharmacological sciences
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
  • APPLICATION DEADLINE
    05/02/2021 23:00 - Europe/Brussels
  • LOCATION
    France › Strasbourg
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    35
  • OFFER STARTING DATE
    15/02/2021

OFFER DESCRIPTION

The postdoctoral fellow will be co-affiliated to the “Laboratoire d'Innovation Moléculaire et Applications (LIMA)” (UMR7042 / CNRS-Unistra-UHA), located in the “European School of Chemistry, Polymers and Materials (ECPM)” and to the “Mosquito Immune Responses (MIR)” unit, (UPR9022/U963 CNRS & Unistra‒INSERM) in Strasbourg. The project is granted by a fellowship from the European University EUCOR. It is based on a solid French-Swiss collaboration between several laboratories: Dr. Elisabeth Davioud-Charvet, an expert in medicinal and biological chemistry of redox-active antiparasitic compounds (LIMA-Strasbourg), Dr. Marjorie Schmitt (LIMA-Mulhouse) who has experience in recombinant protein cloning and crystallization, Dr Christine Schaeffer who has expertise in mass spectrometry & proteomics analysis and access to state-of-the art mass spectrometers (LSMBO, IPHC Strasbourg), Dr. Stephanie Blandin, whose research focuses on the biology of mosquitoes and malarial parasites with access to a brand new secure insectarium and LSB3 laboratories (IBMC, Strasbourg), and Prof. Pascal Maeser, a renowned expert in antiparasitic drug development (STPH, Basel, Switzerland).

Topic: Plasmodione is a new antimalarial lead compound with both curing and transmission-blocking activities. The postdoctoral fellow will make use of photoreactive plasmodione-derived alkynes (ABPP probes) & optimized irradiation conditions to form target-protein adducts in various yeast and E. coli strains, and analyze them by mass spectrometry to identify plasmodione targets (LIMA, LSMBO). These analyses will be extended to parasite cultures and candidate targets will be validated by genetic engineering in Plasmodium (MIR).

More Information

Offer Requirements

Skills/Qualifications

We are looking for a highly motivated and ambitious candidate with a strong background in mass spectrometry analysis of proteins (essential) and possibly experience in biochemistry and cell culture. Additional expertise in click chemistry and/or photoirradiation would be appreciated. The ideal candidate will have a proven track record of scientific excellence, very good communication and writing skills, as well as a strong commitment to experimental work. The candidate should be able to perform independent research and to engage in collaborations with co-workers within this project. Knowledge of the French language is not required, but thorough knowledge of English, both oral and written is mandatory. The postdoc position may be extended by 1 year.

Work location(s)
1 position(s) available at
Université de Strasbourg / LCM UMR 7042 - ECPM
France
Strasbourg
67200
25 rue Becquerel

EURAXESS offer ID: 594801

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