ORGANISATION/COMPANYUniversité de Strasbourg
RESEARCH FIELDBiological sciencesChemistry › BiochemistryPharmacological sciences
RESEARCHER PROFILEFirst Stage Researcher (R1)
APPLICATION DEADLINE05/02/2021 23:00 - Europe/Brussels
LOCATIONFrance › Strasbourg
TYPE OF CONTRACTTemporary
HOURS PER WEEK35
OFFER STARTING DATE15/02/2021
The postdoctoral fellow will be co-affiliated to the “Laboratoire d'Innovation Moléculaire et Applications (LIMA)” (UMR7042 / CNRS-Unistra-UHA), located in the “European School of Chemistry, Polymers and Materials (ECPM)” and to the “Mosquito Immune Responses (MIR)” unit, (UPR9022/U963 CNRS & Unistra‒INSERM) in Strasbourg. The project is granted by a fellowship from the European University EUCOR. It is based on a solid French-Swiss collaboration between several laboratories: Dr. Elisabeth Davioud-Charvet, an expert in medicinal and biological chemistry of redox-active antiparasitic compounds (LIMA-Strasbourg), Dr. Marjorie Schmitt (LIMA-Mulhouse) who has experience in recombinant protein cloning and crystallization, Dr Christine Schaeffer who has expertise in mass spectrometry & proteomics analysis and access to state-of-the art mass spectrometers (LSMBO, IPHC Strasbourg), Dr. Stephanie Blandin, whose research focuses on the biology of mosquitoes and malarial parasites with access to a brand new secure insectarium and LSB3 laboratories (IBMC, Strasbourg), and Prof. Pascal Maeser, a renowned expert in antiparasitic drug development (STPH, Basel, Switzerland).
Topic: Plasmodione is a new antimalarial lead compound with both curing and transmission-blocking activities. The postdoctoral fellow will make use of photoreactive plasmodione-derived alkynes (ABPP probes) & optimized irradiation conditions to form target-protein adducts in various yeast and E. coli strains, and analyze them by mass spectrometry to identify plasmodione targets (LIMA, LSMBO). These analyses will be extended to parasite cultures and candidate targets will be validated by genetic engineering in Plasmodium (MIR).
We are looking for a highly motivated and ambitious candidate with a strong background in mass spectrometry analysis of proteins (essential) and possibly experience in biochemistry and cell culture. Additional expertise in click chemistry and/or photoirradiation would be appreciated. The ideal candidate will have a proven track record of scientific excellence, very good communication and writing skills, as well as a strong commitment to experimental work. The candidate should be able to perform independent research and to engage in collaborations with co-workers within this project. Knowledge of the French language is not required, but thorough knowledge of English, both oral and written is mandatory. The postdoc position may be extended by 1 year.
EURAXESS offer ID: 594801
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