ORGANISATION/COMPANYVrije Universiteit Brussel
RESEARCH FIELDBiological sciences › OtherChemistry › Computational chemistryComputer science › Informatics
RESEARCHER PROFILEFirst Stage Researcher (R1)Recognised Researcher (R2)
APPLICATION DEADLINE15/02/2021 23:00 - Europe/Brussels
LOCATIONBelgium › Brussels
TYPE OF CONTRACTTemporary
HOURS PER WEEK40
OFFER STARTING DATE01/04/2021
The Bio2Byte group led by Prof. Dr. Wim Vranken at the VUB in Brussels, Belgium, works on the prediction of protein characteristics, and the interpretation of these predictions in relation to life science problems such as molecular causes for human diseases or protein design (see https://bio2byte.be/).
We are now starting a project to investigate the relationships between the post-translational modifications (PTMs) of proteins, their subcellular location, and their biophysical characteristics, in collaboration with UGent and UCL. We are looking for a researcher to join us, and contribute to this project by working towards a better understanding of the effect of PTMs (e.g.phosphorylation) on protein conformation and dynamics. This position will be highly collaborative, with researchers at the Bio2Byte group, as well as at the UGent and UCL. We envisage an extensive methodological study of the effect of such PTMs on the local interactions between amino acids in proteins using Molecular Dynamics (MD) approaches. This information should then enable PTM-aware sequence-based predictions of protein characteristics, such as backbone dynamics or conformational propensities. The end goal of the project is to obtain proteome-scale insights in how the sequence, biophysical characteristics, PTMs and protein-protein interactions (PPIs) of proteins relate to their subcellular location, and make this information available to the community.
Our group is very international, with close collaborations within and outside of Europe. We offer an open, dynamic and rewarding working environment, focused on team work and collaborations, with initiative, discussion and originality stimulated.
See https://jobs.vub.be/content/Benefits/?locale=en_GB for more information.
All applications will be pre-screened, and the most suited candidates interviewed online. All candidates will receive feedback on their application.
For a valid application, please fill in the online form: http://bit.ly/b2b_md. It is mandatory to include 1) a CV including at least 2 contacts for references, 2) a complete motivation letter.
- You have a Master’s or Ph.D. degree in (computer) sciences or engineering.
- You have extensive MD experience, especially in the in-depth interpretation of MD simulations.
- You are experienced in Python, and can script MD runs at a large scale, for (modified) peptides
- You are a team worker, who enjoys solving problems in close collaboration with others.
- Additional advantageous skills are:
- Creating MD topologies and/or using different force fields
- General structural bioinformatics
- Machine learning.
EURAXESS offer ID: 594522
The responsibility for the jobs published on this website, including the job description, lies entirely with the publishing institutions. The application is handled uniquely by the employer, who is also fully responsible for the recruitment and selection processes.
Please contact email@example.com if you wish to download all jobs in XML.