02/12/2020
The Human Resources Strategy for Researchers
Marie Skłodowska-Curie Actions

Call for Phd Candidate: Multiscale modelling of IVD cell activity & potential tissue turnover

This job offer has expired


  • ORGANISATION/COMPANY
    Universitat Pompeu Fabra - ETIC
  • RESEARCH FIELD
    Engineering
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
  • APPLICATION DEADLINE
    20/03/2021 23:00 - Europe/Athens
  • LOCATION
    Spain › Barcelona
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    37,5
  • OFFER STARTING DATE
    01/04/2021
  • EU RESEARCH FRAMEWORK PROGRAMME
    H2020 / Marie Skłodowska-Curie Actions
  • MARIE CURIE GRANT AGREEMENT NUMBER
    955735

OFFER DESCRIPTION

The candidate will work on the multiscale modelling of the mechanisms of intervertebral disc regulation. Specifically, the PhD project will target the modelling and simulation of bottom-up processes of tissue regulation, through which the dynamics of cell activity contributes to disc tissue turnover in specific regions of interest, in response to multifactorial cell stimulations. Different types of intervertebral disc network models will be used and combined to successively incorporate cell culture experimental data, proteomics measurements and gene variant effects. Interplays of biochemical, mechanical and nutritional cell stimulation will be modelled in representative volume elements through agent-based modelling. Eventually, collective cell activity will be linked with heterogeneous cell environments predictable through disc tissue and organ finite element models.

 

The European community requires early stage researchers (ESR) who can work across the boundaries of traditional disciplines, integrating experimental and in silico approaches to understand and manage highly prevalent multifactorial disorders, such as musculoskeletal disorders. The Disc4All training network utilises intervertebral disc degeneration (LDD) that leads to low back pain (LBP) as a relevant application for the integration of data and computational simulations in translational medicine, to enable rational interpretations of the complex interactions that can lead to symptoms.

LBP is the largest cause of morbidity worldwide, yet there remains controversy as to the specific cause leading to poor treatment options and prognosis. LDD is reported to account for 50% of LBP in young adults, but the interplay of factors such as genetics, environmental, cellular responses, social and psychological is poorly understood. Unfortunately, the integration of such data into a holistic and rational map of degenerative processes and risk factors has not been achieved, requiring the creation of professional cross-competencies, which current training programmes in biomedicine, biomedical engineering and translational medicine fail to address, individually.

Disc4All aims to tackle this issue through collaborative expertise of clinicians; computational physicists and biologists; geneticists; computer scientists; cell and molecular biologists; microbiologists; bioinformaticians; and industrial partners. It provides interdisciplinary training in data curation and integration; experimental and theoretical/computational modelling; computer algorithm development; tool generation; and model and simulation platforms to transparently integrate primary data for enhanced clinical interpretations through models and simulations. Complementary training is offered in dissemination; project management; responsible research and innovation; ethics; regulation; policy; business strategy; public and patient engagement. Disc4All will train a new generation of internationally mobile professionals with unique skill sets for the development of thriving careers in translational research applied to multifactorial disorders.

Hiring Disc4All Member: Universitat Pompeu Fabra (UPF)

Web: www.upf.edu

UPF was established in 1990 as a public university with a strong dedication to excellence in research and teaching. UPF is in the top 150 universities worldwide and top 50 in Europe, in Engineering and Technology (Times Higher Education rankings 2020). It is one of the leading Spanish universities and the 10th best young university worldwide according to Time Higher Education Under 50 (2020). UPF coordinates Disc4All and takes part in the project through its ICT Department (DTIC), which has more than 60% international researchers from 48 different countries. DTIC is strategically located within the vibrant 22@ technological district of Barcelona. It has been recognized as “María de Maeztu” unit of excellence by the Spanish government for the quality and relevance of its pioneering scientific research (2015-2020). Within DTIC, Disc4All is led from the BCN-MedTech research unit (https://www.upf.edu/web/bcn-medtech/). BCN MedTech has a team of 60 full time researchers, with major focus on computer models and simulations in biomedical engineering for the exploration of disease mechanisms, advanced computer-aided diagnosis, treatment planning and prognosis, among others.

Type of contract: temporary (36 months)

Job status at UPF: full-time

Hours per week: 37,5

Incorporation date: April 2021, at the latest

EU Research Framework: H2020 MSCA-ITN-ETN

Marie Curie Grant Agreement Number: 955735

Position: The successful candidate will work on the multiscale modelling of the mechanisms of intervertebral disc regulation. Specifically, the work will target the modelling and simulation of bottom-up processes of tissue regulation, through which the dynamics of cell activity contributes to disc tissue turnover in specific regions of interest, in response to multifactorial cell stimulations. Different types of intervertebral disc network models will be used and combined to successively incorporate cell culture experimental data, proteomics measurements and eventually gene variant effects. Interplays of biochemical, mechanical and nutritional cell stimulation will be modelled in representative volume elements through agent-based modelling. Eventually, collective cell activity will be linked with heterogeneous cell environments predictable through finite element simulations of disc tissue and organ multiphysics.

Supervision: Jérôme Noailly (UPF)

Co-supervision: Ferran Sanz (IMIM), Leonidas Alexopoulos (PAO), Christine Le Maitre (SHU), Benjamin Gantenbein (UBern)

Main working place: UPF-DTIC, Campus Poble Nou, Barcelona, Spain (https://www.upf.edu/web/etic)

Working lab: BCN-MedTech (https://www.upf.edu/web/bcn-medtech/)

More Information

Benefits

The MSCA programme offers a competitive salary and attractive working conditions, in accordance with the MSCA regulations for early stage researchers.

You will be enrolled in the PhD programme of Information and Communication Technologies of the UNIVERSITAT POMPEU FABRA – UPF (https://www.upf.edu/web/etic/doctorat), and have the opportunity to learn form a consortium of 19 institutions (11 Beneficiaries, 8 Partner organizations - https://www.upf.edu/web/disc4all/beneficiaries). In addition to the individual scientific projects, all ESRs will benefit from further continuing education, which includes secondments (to ProtATonce, to Sheffield Hallam University and to the University of Bern, for this specific project), a variety of training courses for specific and transferable skills and active participation and international conferences.

Successful candidates will be offered a 36 months full-time employment contract, with a monthly average gross salary of 3119 €, plus a mobility allowance of 600€ per month (unconditional) and a family allowance of 500€ per month (if applicable).

All the amounts mentioned above are expressed before statutory deductions in charge of the Institution and the candidate: National Insurance and Income Tax.

Eligibility criteria

a) To apply for these MSCA Training positions, applicants must fulfil the following criteria:

• Mobility: to be eligible for a position, you shall not have resided in the same country as the host institution for more than 12 months over the three years previous to the start date of the position, excluding holidays and (refugee status) asylum application.

• Early Stage Researcher (ESR): An ESR shall at the time of recruitment by the host organisation, be in the first four years (full-time equivalent research experience) of their research careers and have not been awarded a doctoral degree.

Candidates must prove that they fulfil the aforementioned criteria through relevant documentation (certificates, official statements, residency card, …).

b) Specific requirements for the proposed project:

• Educational Level: Biomedical Engineering, Physics, Mathematics, Biomedicine or other related fields (master degree or equivalent)

• Required languages: English

• Skills/Qualifications: Experience with data infrastructure design and cloud services

• Eligibility to enrol in the PhD programme at the Universitat Pompeu Fabra (https://www.upf.edu/web/etic/doctorat)

Selection process

The selection committee uses a number of indicators to evaluate the applicant’s preparedness, motivation and potential.

1st phase, remote pre-selection:

The Scientific, Technological & Academic excellence will be considered at first, based on:

• Quality of the CV, in general

• Any demonstrated research experience, particularly if supported by evidences such as scientific publications, patents, participation in scientific congresses, …

• Undergraduate performance: overall, with a special focus on relevant field-specific courses

• Any demonstrated previous recognitions (grants, awards, …)

• Reference letters provided by professors and senior scientists: Three refence letters are expected. At least two letters must be issued by scholars. The third letter can be provided either by a scholar or by a relevant professional of the industrial sector. Referees are asked to address analytical capabilities, technical proficiency, ability to work independently and motivation/commitment.

• Statement of purpose: past research experience, motivation for applying to this particular PhD project, academic fit, contribution of the project to the candidate’s future careers plans, ...

• Additional relevant skills (field-specific): demonstrated, e.g. through previous projects, and or through previous participation in scientific contests, trainings, ...

2nd phase, interview(s):

Should the candidate be preselected at phase 1, a second phase will consist in at least one interview through which the motivation, the proactive behaviour, the capacity to work collaboratively, the organizational skills, the communication skills and the capacity to engage in a scientific discussion and manage problems, will be assessed, among other aspects.

The final decision will be the result of a consensus of a recruitment committee that will take into account the results of both recruitment phases 1 and 2. The candidate will be informed of the section results by email.

Application Process:

All the documents that prove the eligibility of the candidate and should be provided. As for the selection process candidates are expected to provide at least the following documents:

• A brief introduction letter (no more than one A4 page) that summarizes the documents and the nature of the information provided for the selection

• A full CV

• The three requested reference letters

• The letter of purpose (no more than two A4 pages)

All documents must be sent by email to the Principal Investigator of the proposed project (Jérôme Noailly – jerome.noailly@upf.edu) and to the Management of the Disc4All project (disc4all@upf.edu) by February 20th, 2021

Work location(s)
1 position(s) available at
Universitat Pompeu Fabra - ETIC
Spain
Barcelona
08018
Roc Boronat 138

EURAXESS offer ID: 583052

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