Seeking a Part timer (Y20013)(Laboratory for Transcriptome Technology)

    RIKEN(The Institute of Physical and Chemical Research)
    Biological sciences
    First Stage Researcher (R1)
    06/11/2021 23:59 - Asia/Tokyo
    Japan › Kanagawa
    See description


Laboratory for Transcriptome Technology
RIKEN Center for Integrative Medical Sciences
(Team Leader: Piero Carninci)

[Research Field]
The Laboratory for Transcriptome Technology develops technologies to comprehensively study the non-protein-coding part of the genome and comprehensively screen its functions, including the study of long non-coding RNAs. Using original technologies, we explore regulatory interactions, including those centered of ncRNAs, with particular emphasis on the interaction of non-coding RNA with chromatin, , RNA binding proteins, retrotransposition and lncRNAs having a role in the translational regulation of protein synthesis. Altogether, novel findings will pave the way towards development of future therapies. Additional emphasis will be on development and standardization of RNA profiling technologies like polysome interaction, RNA Fluorescent In situ Hybridization (FISH), RNA binding protein interaction (RIP, CLIP-seq), in vivo SHAPE (icSHAPE), Mass Spectrometry, RNA modification and the cap-analysis gene expression (CAGE) and its variants to develop a universal and finely quantitative transcriptome technology, which will ultimately be used to profile regulatory lncRNAs.

For more information, please refer to the Job posting URL
Laboratory for Transcriptome Technology

[Job title and Job description]
Job title:
One opening for a Research Part-time Staff

Job description:
We seek a part timer to perform various molecular biology duties potentially including cell culture work, transfection, RNA measurement with qPCR and protein measurement with western blotting in addition to providing general technical support for research staff. A general background in molecular biology techniques coupled with a strong work ethic and desire to learn is required, while previous experience in one or more of the above areas is preferred.

Project Name: SINEUP RNAs: novel non-coding RNA that enhance protein translation
We want to dissect the function of a novel class of non-coding RNAs, called SINEUPs, which have the function of overly enhance translation of protein in mammalian system. We propose to develop SINEUPs as tools for biotechnology, having a function opposite to siRNAs and miRNAs. To do this, we will dissect their function by deletion mutants and will further explore the natural extent of natural SINEUPs in many species. We will finally demonstrate the power of SINEUPs to stimulate the production of a protein of interest, like a human antibody. SINEUPs will be used in the future as general tools to perturb gene function by enhancing, and more importantly, they have the potential to become powerful RNA therapeutics.

The candidate will work with translation assays and cell culture system to analyze features of the non-coding RNAs using molecular biology, cell biology and genomics tools. The candidate will support research towards understanding of the functions and mechanisms of a novel class of non-coding RNA and support laboratory management (keep and order reagents, maintain instruments, clean laboratory. etc.).

[Work location]
RIKEN Center for Integrative Medical Sciences
1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan

[Start of Employment]
at the earliest possible opportunity

Genomics, computational biology, transcriptome, cell biology, translational regulation

More Information


For details about "Salary and benefits", please refer to the above "Job posting URL".

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RIKEN(The Institute of Physical and Chemical Research)

EURAXESS offer ID: 576561
Posting organisation offer ID: D120110220


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