RESEARCH FIELDBiological sciences
RESEARCHER PROFILEFirst Stage Researcher (R1)
APPLICATION DEADLINE31/10/2020 17:00 - Europe/Brussels
LOCATIONFrance › Lille
TYPE OF CONTRACTTemporary
HOURS PER WEEK39
A 3-years postdoctoral position is available at the Lille University Hospital (CHU Lille) and INSERM UMR1277, Lille France in precision cellular immunotherapy. This is part of a highly collaborative project led by Dr. Suman Mitra, Pr. Jos Melenhorst and Pr. Franck Morschhauser. The candidate will work in Dr. Suman Mitra’s group at INSERM 1277 Lille and CHU de Lille in close collaboration with Prof. Jos Melenhorst at the Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania. The candidate will have a terminal degree (PhD, MD, DVM). The candidate should be willing to travel and will spend time both in USA and France. She or he will work under the guidance of Prof. Melenhorst and Suman Mitra assume responsibility for specific projects focused on dissecting the immunobiology of chimeric antigen receptor (CAR) T cell therapies for Non-Hodgkin’s Lymphoma. This is truly a translational research project with the goal to identify novel mechanisms-based biomarkers of therapeutic response and failure of CAR-T therapy in Non-Hodgkin lymphoma. This is a highly collaborative project led by dept of hematology Lille (Prof. Franck Morschhauser, Ibrahim Yakoub Agha), Suman Mitra (Inserm 1277 Lille) and Prof. Jos Melenhorst (UPenn).
The position will involve DNA and RNA sequencing, flow cytometry and other advanced single cell proteomics and transcriptomics approaches, gene modifications of T cells using lentiviral or other vectors. The position will serve to extend, refine, and enhance skills necessary for professional and career development. Furthermore, this position will enable the candidate to broaden her/his scientific background by acquiring new research capabilities. The candidate is expected to conduct research independently, prioritize and multitask, and thrive in a highly collaborative environment in both Upenn and Lille. She or He will have the opportunity to build working relationships with leading clinicians and scientists to broaden scientific knowledge and skills. The candidate will spend significant amount of time at the Melenhorst laboratory, USA and is also expected to travel to Lille, France, to set up the bioanalytical pipeline in the Mitra lab. The post-doc is furthermore expected to participate in and take ownership of project planning, the development of experimental procedures and maintaining their laboratory notebook, plus data analysis and the communication of their results at laboratory, department, and scientific meetings, and via summarizing his/her data in progress reports and manuscripts. The post-doc is also expected to acquire the technical skills, contribute to laboratory management, budget management, and grant writing. Further, the post-doctoral fellow is expected to train and supervise junior lab members and be an effective team member. The position is available immediately.
Please forward a cover letter describing your career plans, updated CV with research statement and the names/contact information for 3 professional references to:
to Suman Mitra, PhD
Institute for Cancer Research in Lille (SWIR)
UMR 9020 CNRS, INSERM UMR-S 1277
59045 Lille Cedex, France
and, to J. Joseph Melenhorst, PhD
Department of Pathology and Laboratory Medicine
Center for Cellular Immunotherapies
Perelman School of Medicine
University of Pennsylvania
- Culture of human T cells and T cell subsets under standard and to-be-developed conditions
- Gene modification of the T cells using RNA and/or CRISPR/Cas9 electroporation, lentiviral transduction, and other gene modification technologies
- Utilize flow cytometry and other advanced single cell proteomics approaches
- Conduct independent scientific research, develop novel methods
- Effectively prioritize, multitask, and thrive in a collaborative environment
- Participate in, and at some point, take ownership of project planning, including budget management
- Contribute to laboratory management
- Communicate the results via oral and poster presentations, progress reports, and manuscripts
- Contribute to grant writing
- Train and supervise junior lab members
Basic Qualifications: Ph.D. and/or M.D. in immunology or genetics. Must have research experience in the cellular and molecular aspects of T cell immunology. Able to work well in a highly dynamic, collaborative work environment.
EURAXESS offer ID: 558576
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