30/06/2020
The Human Resources Strategy for Researchers

PhD Position - Maintenance of a dynamic steady state in the mitotic spindle studied by bottom-up biochemistry and micromanipulation of gene-edited cells


  • ORGANISATION/COMPANY
    Centre For Genomic Regulation
  • RESEARCH FIELD
    Biological sciencesBiology
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
  • APPLICATION DEADLINE
    15/07/2020 23:00 - Europe/Brussels
  • LOCATION
    Spain › Barcelona
  • TYPE OF CONTRACT
    To be defined
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    40
  • OFFER STARTING DATE
    01/10/2020

The institute

The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG shares principles of an interdisciplinary, motivated and creative scientific team that is supported by high-end and innovative technologies and a flexible and efficient administration.

In November 2013, the Centre for Genomic Regulation (CRG) received the 'HR Excellence in Research' logo from the European Commission. This is a recognition of the Institute's commitment to developing an HR Strategy for Researchers, designed to bring the practices and procedures in line with the principles of the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers (Charter and Code).

Please, check out our Recruitment Policy

The role

One PhD Position open to work in the Intracellular Self-Organization Lab at CRG, Barcelona.

About the group

The cytoskeleton is essential for the life of eukaryotic cells. Self-organized filament networks determine the function of the cytoskeleton. Correct coordination of protein activities is critical for the establishment of proper network states. One important task of the microtubule cytoskeleton is to build the mitotic spindle when cells divide to segregate the genetic material. A fascinating coordination task for the cell is to control spindle size, while at the same time microtubules depolymerize at spindle poles and polymerize in the spindle centre, as microtubules flux poleward. Several proteins, such as dynein and other molecular motors together with microtubule depolymerases are known to be involved in this process. However, the molecular mechanism that controls their coordinated action and leads to the establishment of a dynamic, yet stable steady state is not understood.

The Surrey lab recently relocated to the Centre for Genomic Regulation (CRG) in Barcelona, Spain. The overall goal of the lab is to understand how the cytoskeleton self-organizes and reorganizes itself, for example to form the mitotic spindle during cell division. The Surrey team has pioneered a number of fluorescence microscopy-based in vitro reconstitutions of dynamic microtubule cytoskeleton behaviour and contributed to advance our understanding of the molecular mechanisms underlying microtubule cytsokeleton function. The team is interdisciplinary consisting of biochemists, physicists and cell biologists. Advanced optical microscopy is a key method used in the lab. Recently CRISPR/Cas9 gene-editing in cultured human cells was established.

The PhD researcher will integrate at the CRG in Barcelona in a research center with international teams representing a broad range of disciplines, with first class core facilities to support the research project, a wide range of seminars given by high-profile invited speakers, and courses on complementary and transferable skills. He/she will be part of the PhD community at the CRG, which is highly active in organizing scientific and social activities.

Information on the Surrey lab: https://www.crg.eu/en/programmes-groups/surrey-lab

Information on the CRG PhD Programme: http://www.crg.eu/phd_fellowships

Benefits

The offer

  • Contract duration: 4 year PhD Position
  • Estimated annual gross salary: Salary is commensurate with qualifications and consistent with our pay scales.

The successful applicant will enroll in the very active CRG International PhD program, which includes science and practical courses, a wide range of complementary skills training, access to many courses, mentoring via a thesis committee, and active participation in the organization of seminars, symposia and retreats.

We provide a highly stimulating environment with state-of-the-art infrastructures, and unique professional career development opportunities.

We offer and promote a diverse and inclusive environment and welcomes applicants regardless of age, disability, gender, nationality, race, religion or sexual orientation.

Eligibility criteria

Application procedure

Applications are accepted exclusively online. Proposals must be written in English. Please APPLY through the CRG Career Site: https://recruitment.crg.eu/

Candidates may contact imma.falero@crg.eu for informal enquiries regarding the application and address scientific enquiries to thomas.surrey@crg.eu.

Selection process

Selection Process

  • Pre-selection: The pre-selection process will be based on qualifications and expertise reflected on the candidates CVS. It will be merit-based.
  • Interview: Preselected candidates will be interviewed by the Hiring Manager and Graduate Committe
  • Offer Letter: Once the successful candidate is identified the Human Resources department will send a Job Offer, specifying the start day, salary, working conditions, among other important details.

Offer Requirements

  • REQUIRED LANGUAGES
    ENGLISH: Excellent

Skills/Qualifications

We are looking for a PhD student to join our project where we will use a synthetic bottom-up approach that allows to study cytoskeletal self-organization processes in minimal reconstituted systems. We will compare the behaviour of the reconstituted systems with that of custom-designed gene-edited cells. Methods to be used will be protein biochemistry, TIRF and confocal fluorescence microscopy, optical perturbations (laser cutting, photoactivation), gene-engineering in cultured human cells, etc. We will ask how the activities of plus and minus directed motors and microtubule dynamics regulators are coordinated to achieve the correct steady state organization. Our goal is to understand how the global characteristics of a biological system are produced by the self-regulated coordination of local molecular activities.

Specific Requirements

  • Candidates should hold a University Degree and a Master’s Degree

Map Information

Job Work Location Personal Assistance locations
Work location(s)
1 position(s) available at
Centre For Genomic Regulation
Spain
Barcelona
Barcelona
08003
Dr. Aiguader, 88

Open, Transparent, Merit based Recruitment procedures of Researchers (OTM-R)

Know more about it at Centre For Genomic Regulation

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EURAXESS offer ID: 537573

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