ORGANISATION/COMPANYCentre For Genomic Regulation
RESEARCH FIELDBiological sciences › Biology
RESEARCHER PROFILEFirst Stage Researcher (R1)
APPLICATION DEADLINE15/07/2020 23:00 - Europe/Brussels
LOCATIONSpain › Barcelona
TYPE OF CONTRACTTo be defined
HOURS PER WEEK40
OFFER STARTING DATE01/10/2020
The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG shares principles of an interdisciplinary, motivated and creative scientific team that is supported by high-end and innovative technologies and a flexible and efficient administration.
In November 2013, the Centre for Genomic Regulation (CRG) received the 'HR Excellence in Research' logo from the European Commission. This is a recognition of the Institute's commitment to developing an HR Strategy for Researchers, designed to bring the practices and procedures in line with the principles of the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers (Charter and Code).
One PhD Position open to work in the Intracellular Self-Organization Lab at CRG, Barcelona.
About the group
The cytoskeleton is essential for the life of eukaryotic cells. Self-organized filament networks determine the function of the cytoskeleton. Correct coordination of protein activities is critical for the establishment of proper network states. One important task of the microtubule cytoskeleton is to build the mitotic spindle when cells divide to segregate the genetic material. A fascinating coordination task for the cell is to control spindle size, while at the same time microtubules depolymerize at spindle poles and polymerize in the spindle centre, as microtubules flux poleward. Several proteins, such as dynein and other molecular motors together with microtubule depolymerases are known to be involved in this process. However, the molecular mechanism that controls their coordinated action and leads to the establishment of a dynamic, yet stable steady state is not understood.
The Surrey lab recently relocated to the Centre for Genomic Regulation (CRG) in Barcelona, Spain. The overall goal of the lab is to understand how the cytoskeleton self-organizes and reorganizes itself, for example to form the mitotic spindle during cell division. The Surrey team has pioneered a number of fluorescence microscopy-based in vitro reconstitutions of dynamic microtubule cytoskeleton behaviour and contributed to advance our understanding of the molecular mechanisms underlying microtubule cytsokeleton function. The team is interdisciplinary consisting of biochemists, physicists and cell biologists. Advanced optical microscopy is a key method used in the lab. Recently CRISPR/Cas9 gene-editing in cultured human cells was established.
The PhD researcher will integrate at the CRG in Barcelona in a research center with international teams representing a broad range of disciplines, with first class core facilities to support the research project, a wide range of seminars given by high-profile invited speakers, and courses on complementary and transferable skills. He/she will be part of the PhD community at the CRG, which is highly active in organizing scientific and social activities.
Information on the Surrey lab: https://www.crg.eu/en/programmes-groups/surrey-lab
Information on the CRG PhD Programme: http://www.crg.eu/phd_fellowships
- Contract duration: 4 year PhD Position
- Estimated annual gross salary: Salary is commensurate with qualifications and consistent with our pay scales.
The successful applicant will enroll in the very active CRG International PhD program, which includes science and practical courses, a wide range of complementary skills training, access to many courses, mentoring via a thesis committee, and active participation in the organization of seminars, symposia and retreats.
We provide a highly stimulating environment with state-of-the-art infrastructures, and unique professional career development opportunities.
We offer and promote a diverse and inclusive environment and welcomes applicants regardless of age, disability, gender, nationality, race, religion or sexual orientation.
Applications are accepted exclusively online. Proposals must be written in English. Please APPLY through the CRG Career Site: https://recruitment.crg.eu/
- Pre-selection: The pre-selection process will be based on qualifications and expertise reflected on the candidates CVS. It will be merit-based.
- Interview: Preselected candidates will be interviewed by the Hiring Manager and Graduate Committe
- Offer Letter: Once the successful candidate is identified the Human Resources department will send a Job Offer, specifying the start day, salary, working conditions, among other important details.
REQUIRED LANGUAGESENGLISH: Excellent
We are looking for a PhD student to join our project where we will use a synthetic bottom-up approach that allows to study cytoskeletal self-organization processes in minimal reconstituted systems. We will compare the behaviour of the reconstituted systems with that of custom-designed gene-edited cells. Methods to be used will be protein biochemistry, TIRF and confocal fluorescence microscopy, optical perturbations (laser cutting, photoactivation), gene-engineering in cultured human cells, etc. We will ask how the activities of plus and minus directed motors and microtubule dynamics regulators are coordinated to achieve the correct steady state organization. Our goal is to understand how the global characteristics of a biological system are produced by the self-regulated coordination of local molecular activities.
- Candidates should hold a University Degree and a Master’s Degree
EURAXESS offer ID: 537573
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