10/06/2020
Marie Skłodowska-Curie Actions

PhD in Structural Biology

This job offer has expired


  • ORGANISATION/COMPANY
    Helmholtz Institute for Pharmaceutical Research Saarland
  • RESEARCH FIELD
    Biological sciencesBiological engineering
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
  • APPLICATION DEADLINE
    03/07/2020 23:00 - Europe/Brussels
  • LOCATION
    Netherlands › Groningen
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    40
  • EU RESEARCH FRAMEWORK PROGRAMME
    H2020 / Marie Skłodowska-Curie Actions
  • MARIE CURIE GRANT AGREEMENT NUMBER
    860816

OFFER DESCRIPTION

This project will focus on the structural analysis of DXS and IspD enzymes form a variety of pathogenic organisms (including malaria and tuberculosis) to support the design and synthesis of selective and potent inhibitor(s) of the MEP pathway. As initial crystallisation

conditions for the tubercular enzyme are available, the initial stages will focus on a fragment screen of this system, but the successful

candidate would be expected to apply these successful approaches to the DXS of other organisms of interest. The ESR will need to be able to liaise closely with the other ESRs to provide structural data to drive compound evolution. Training in cutting edge X-ray data collection and biophysical techniques will be provided.

More Information

Work location(s)
1 position(s) available at
Univeristy of Groningen
Netherlands
Groningen

EURAXESS offer ID: 531068

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