04/06/2020

PhD in Advanced microscopy of supra-assemblies regulating cell growth

This job offer has closed


  • ORGANISATION/COMPANY
    Universitat Pompeu Fabra
  • RESEARCH FIELD
    Biological sciences
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
  • APPLICATION DEADLINE
    30/06/2020 23:00 - Europe/Brussels
  • LOCATION
    Spain › Barcelona
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    40

OFFER DESCRIPTION

We look for an enthusiastic PhD student that is willing to develop a new microscopy technique that allows us to understand how cells regulate the expansion of their membranes and how they can adapt this process to grow under different environments.

 

Membrane expansion is essential to control cell growth, the cell surface composition, cell polarity, morphogenesis, cell differentiation and neurobiology. This is a process controlled by large and dynamic protein machines formed by multiple protein complexes that assemble transiently and that act in a coordinated manner. Despite the work of many laboratories, the dynamism and complexity of this process did not allow resolving the mechanism behind the action of such a large protein machinery. To be successful, we will use Saccharomyces cerevisiae as a model organism and we will develop new methods that combine light microscopy and electron microscopy. Thus, we will be able to time-resolve the cell machinery with unprecedented resolution. The development of this technology will be done together with other members of the lab and in collaboration with groups in Switzerland and Australia.

This is a 4-year PhD position in the group of Oriol Gallego at the department of Experimental and Health Sciences (DCEXS) of the Pompeu Fabra University. The student will be part of a newly emerging research lab devoted to study supra-molecular machineries that control cell growth. We are building a team of scientist with different expertise where you are expected to contribute and collaborate. DCEXS research excellence has been recognized with a Maria de Maeztu award and our PhD program is entirely in English.

Ours is an interdisciplinary research in the frontier of cell biology, biophysics, computational modelling and structural biology. We develop methods of fluorescence microscopy that allow the structural analysis of molecular assemblies in vivo. We then integrate the structural and biophysical measurements in computational models, which allows us to solve questions in cell biology that were not accessible by other techniques (Picco et al, 2017, Cell; Irastorza-Azcarate et al, 2019, Structure). We are well equipped, with have our own microscope for live-cell imaging and single molecule localization microscopy. As part of the Pompeu Fabra University, the lab is located at the PRBB, one of the strongest scientific campus in south Europe. With state-of-the-art research facilities, PRBB offers an ideal scientific and international environment.

Requirements

-Background in Biophysics, Optical physics, Biomedical Sciences, Biology, Biochemistry, or similar.

-A minimum of 1-year expertise in a research lab is required.

-Expertise in fluorescence microscopy, programming or membrane trafficking is a plus.

-Excellent written and oral communication skills in English.

How to apply To apply, please send your CV, motivation letter and contact details of two referees to Dr Oriol Gallego (oriol.gallego@upf.edu) before 30/06/2020.

More Information

Eligibility criteria

Degree: Master (or equivalent) to start a PhD in the 2020-2021 academic year

Additional comments

 

Envisaged Job Starting Date Autumn 2020

Web site for additional job details: www.gallegolab.org

Required Research Experiences

  • RESEARCH FIELD
    Biological sciences
  • YEARS OF RESEARCH EXPERIENCE
    1 - 4

Offer Requirements

  • REQUIRED EDUCATION LEVEL
    Biological sciences: Master Degree or equivalent
  • REQUIRED LANGUAGES
    ENGLISH: Excellent

Specific Requirements

-Background in Biophysics, Optical physics, Biomedical Sciences, Biology, Biochemistry, or similar. -A minimum of 1-year expertise in a research lab is required. -Expertise in fluorescence microscopy, programming or membrane trafficking is a plus. -Excellent written and oral communication skills in English.

Map Information

Job Work Location Personal Assistance locations
Work location(s)
1 position(s) available at
Universitat Pompeu Fabra
Spain
Barcelona
08003
Dr. Aiguader, 88

EURAXESS offer ID: 529281

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