30/05/2020
The Human Resources Strategy for Researchers

PhD - Biophysics of the interaction between bacteria and surfaces (H/F)

This job offer has expired


  • ORGANISATION/COMPANY
    CNRS
  • RESEARCH FIELD
    ChemistryPhysical chemistry
    PhysicsBiophysics
    PhysicsChemical physics
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
  • APPLICATION DEADLINE
    29/06/2020 23:59 - Europe/Brussels
  • LOCATION
    France › LYON 07
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    35
  • OFFER STARTING DATE
    01/10/2020

OFFER DESCRIPTION

The PhD will take place in the group “Physics of biological systems” at ENS de Lyon (http://www.ens-lyon.fr/PHYSIQUE/teams/matiere-complexite/research-topics...), in collaboration with biologists in the team Biology of Cancer and Infection at CEA Grenoble (http://www.bci-lab.fr/en/Pages/PBRC/Presentation.aspx). We are looking for candidates with a background in soft matter physics/biophysics/bioengineering, but the main prerequisite is a strong interest in interdisciplinary questions.

Bacteria meet surfaces: how the micromechanical environment impacts bacterial virulence

Bacteria adhere to surfaces where they form macrocolonies called biofilms. However, the cues that regulate the switch from an individual motile lifestyle to a collective one are not clear. Building on recent evidence, we propose to study whether the bacterial mechanical microenvironment influences this transition. Using a cross-disciplinary approach, we will image bacteria in flow cells in situ as they adhere on mechanically controlled substrates, which rigidity can be tuned from 1-100kPa. Combining imaging and transcriptome sequencing approaches, we will investigate the correlation between mechanical cues, bacterial organization and virulence regulation in early surface colonization.

More Information

Required Research Experiences

  • RESEARCH FIELD
    ChemistryPhysical chemistry
  • YEARS OF RESEARCH EXPERIENCE
    None
  • RESEARCH FIELD
    PhysicsChemical physics
  • YEARS OF RESEARCH EXPERIENCE
    None
  • RESEARCH FIELD
    PhysicsBiophysics
  • YEARS OF RESEARCH EXPERIENCE
    None

Offer Requirements

  • REQUIRED EDUCATION LEVEL
    Chemistry: Master Degree or equivalent
    Physics: Master Degree or equivalent
  • REQUIRED LANGUAGES
    FRENCH: Basic
Work location(s)
1 position(s) available at
LABORATOIRE DE PHYSIQUE DE L'ENS DE LYON
France
LYON 07

EURAXESS offer ID: 527775
Posting organisation offer ID: 15689

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