Early Stage Researcher / PhD candidate Position

This job offer has expired

    Jena University Hospital (UKJ), FSU
    Biological sciences
    Medical sciences
    Pharmacological sciences
    First Stage Researcher (R1)
    Recognised Researcher (R2)
    Established Researcher (R3)
    Leading Researcher (R4)
    20/05/2020 23:59 - Europe/Brussels
    Germany › Jena

*Early Stage Researcher / PhD candidate Position:*
*Host response biomarkers for bacterial infections using RNA profiling and Raman spectroscopy (ESR 13)*

Institute of Infectious Diseases and Infection Control at the Jena University Hospital (Germany) has available an Early Stage Researcher / PhD candidate position on “Host response biomarkers for bacterial infections using RNA profiling and Raman spectroscopy (ESR 13)” as part of the Innovative Training Network (ITN) Training towards Innovative Personalized Antibiotic Therapy (TIPAT).

The Innovative Training Network (ITN) Training towards Innovative Personalized Antibiotic Therapy (TIPAT) has started March 1, 2020. TIPAT offers a cutting-edge training-by-research program for 15 Early stage researchers (ESRs) / PhD candidates. TIPAT is part of the Marie Skłodowska-Curie International Training Network (ITN) of the European Commission. ESRs in TIPAT will be part of an international network of universities, hospitals and companies. To enable development of innovative personalized antibiotic treatment strategies, quantitative understanding of the interplay between drug, pathogen and host is crucial. The TIPAT network will train inter-disciplinary specialists optimally equipped with a skill set to address this challenge. Central to the TIPAT research and training program of ESRs is the combination of state-of-the art quantitative modelling with approaches in clinical pharmacology, immunology and microbiology, which enables development of innovative methodology to personalized antibiotic therapies.

Project description
Preclinical evaluation of antibiotic efficacy is predominantly performed in non‐physiological rodent models to facilitate colonization while potential synergistic and detrimental effects of the immune response are neglected. This raises questions on the relevancy and translatability of animal models to human infection. To address this knowledge gap, on how immune factors contribute to the resolution of infection, we aim to establish well‐standardized murine models that allows following the in vivo dynamics of bacterial spread along with changes in the immune response. We will comparatively analyze infection and antibiotic therapies in immunocompetent and immunosuppressed mice, but also human and murine immune response signatures to identify molecular factors influencing the hepatic host response in life‐threatening bacterial infections. The aim is to identify immune signatures associated with early therapeutic efficacy, with the potential to allow early decision making on the appropriateness of the selected antibiotic regimen, if brought from bench‐to‐bedside.
This project will be performed in close collaboration with the Paul-Ehrlich Institute (Germany), who will establish the mouse models and provide samples, and the University of Uppsala (Sweden), who will develop mathematical models describing the interaction between immune response and bacteria, in relation to antibiotic treatment.

Selection criteria
• Master degree in the field of microbiology, biology, biotechnology, or equal (graduation before project start date)
• Experience in microbiological (working under sterile condition, culturing of cells lines and microorganisms) and molecular techniques (isolation of nucleic acids, PCR methods, electrophoresis) are mandatory, experience in fluorescence microscopy, resistance testing and cytology are desirable.
• Good communication and interpersonal skills to organize research with both academics and professionals;
• Good communication (verbal and writing) skills in English;
• Confirmed capacity to write high-level scientific reports and papers;
• Interested in participating in educational tasks;
• Independent and creative team player;

Planned start of employment: Between 01-09-2020 and 01-11-2020

Duration of position: 36 months

• At the time of commencing their employment, researchers must not have resided or carried out their main activity (work, studies, etc.) in the country of their (recruiting) host organization for more than 12 months in the 3 years prior to their recruitment.
• Applicants must be in the first four years (full-time equivalent research experience) of their research career and have not been awarded a doctoral degree at the first day of their employment contract. This research experience is measured from the date when they obtain the degree which formally entitles them to embark on a doctorate (either in the country in which the degree was obtained or in the country in which the researcher is recruited), even if a doctorate was never started or envisaged. Research experience is measured to the first day of the employment contract of the researcher.
• Usual MSCA eligibility criteria apply and will be verified during the application process. For more information on MSCA, please see: http://ec.europa.eu/mariecurieactions. Benefits

• The successful candidates will receive a 36-month, full-time employment contract as per Marie Skłodowska-Curie Actions (MSCA) regulations for early stage researchers. The monthly salary will be confirmed upon offer, paid in the currency of the host country, and with a correction factor applied to the host country.
• In addition to their individual scientific projects, TIPAT ESRs will collaborate with world-leading research groups and industries within the consortium through secondments. All ESRs will benefit from further extensive and varied continuing education, completing a series of carefully designed training modules and transferable skills courses; they will participate in symposia, workshops, and international conferences and will have meaningful exposure to the industrial environment through TIPAT industrial partners.

Application procedure
Questions about this position can be send to Dr. Oliwia Makarewicz (email: oliwia.makarewicz@med.uni-jena.de).

Your application should be sent to oliwia.makarewicz@med.uni-jena.de and to applications@tipat.eu

When applying, please use the following email subject title: TIPAT ESR13 - Your Name

In your application please include the following files:
• A motivation letter (1 page maximum), please include in your letter alternative ESR TIPAT positions of interest to you if not selected, if any.
• A CV according to the Europass format
• Two reference letters (at least one from your Master thesis supervisor)
• An up-to-date of grades in your bachelor and master programs
• Optional: English proficiency test results (TOEFL, IELTS)
• Additional certificates documenting your skills are welcome

The application deadline is May 20, 2020. We may extend this deadline depending on the developments of the COVID19 pandemic.

The application procedure is as follows:
- A notification for receiving your application is send after the application deadline.
- Applicants are notified if they are invited for video-conferencing interviews by May 30
- Interviews are schedule to be completed by June 15
- Hiring process is completed by June 30

Please note these dates may change if the application deadline is extended.

This project has received funding from the European Union's Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No 861323.

Offer Requirements



Work location(s)
1 position(s) available at
Jena University Hospital (UKJ), FSU

EURAXESS offer ID: 514988
Posting organisation offer ID: 724877


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