ORGANISATION/COMPANYMedical University of Vienna
RESEARCH FIELDPharmacological sciences › Clinical pharmacology
RESEARCHER PROFILEFirst Stage Researcher (R1)
APPLICATION DEADLINE22/06/2020 17:00 - Europe/Brussels
LOCATIONAustria › Vienna
TYPE OF CONTRACTTemporary
HOURS PER WEEK40
EU RESEARCH FRAMEWORK PROGRAMMEH2020 / Marie Skłodowska-Curie Actions
MARIE CURIE GRANT AGREEMENT NUMBER861323
Early Stage Researcher / PhD candidate Position:
Host factors impacting protein binding of highly protein bound drugs in‐vivo (ESR 2)
The department of clinical pharmacology (MUW) has available an Early Stage Researcher / PhD candidate position on “Host factors impacting protein binding of highly protein bound drugs in‐vivo” as part of the Innovative Training Network (ITN) Training towards Innovative Personalized Antibiotic Therapy (TIPAT).
The Innovative Training Network (ITN) Training towards Innovative Personalized Antibiotic Therapy (TIPAT) has started March 1, 2020. TIPAT offers a cutting-edge training-by-research program for 15 Early stage researchers (ESRs) / PhD candidates. TIPAT is part of the Marie Skłodowska-Curie International Training Network (ITN) of the European Commission. ESRs in TIPAT will be part of an international network of universities, hospitals and companies. To enable development of innovative personalized antibiotic treatment strategies, quantitative understanding of the interplay between drug, pathogen and host is crucial. The TIPAT network will train inter-disciplinary specialists optimally equipped with a skill set to address this challenge. Central to the TIPAT research and training program of ESRs is the combination of state-of-the art quantitative modelling with approaches in clinical pharmacology, immunology and microbiology, which enables development of innovative methodology to personalized antibiotic therapies.
This PhD will set out to optimize antimicrobial therapy based on personalized medicine to determine optimal individualized dosing strategies. Only the free, meaning non-protein bound fraction of an antibiotic is active against a bacterial pathogen. Various methods for determination of protein binding do exist, but they are poorly standardized and understood in particular in the light of pathophysiological conditions in a critically ill patient. Therefore, bound and unbound antibiotic concentration in vivo will be determined in different patient populations and healthy volunteers in clinical studies. To this aim, different methods (ultrafiltration, equilibrium dialysis, microdialysis in vitro and in vivo) will be established for multiple classes of antibiotics with different protein binding.
The work will help to understand the dynamic process of protein binding in‐vivo and to characterize relationships between the unbound fraction and total drug concentration, serum‐based biomarkers of the host, and parameters from mechanistic molecule‐based modelling. This will have major impact on the interpretation of data from therapeutic drug monitoring in patients all over the world. There will be planned secondments in Sweden and Poland.
Planned start of employment: Between 01-09-2020 and 01-11-2020
Duration of position: 36
Content related questions about this position can be send to Prof. Markus Zeitlinger (email: firstname.lastname@example.org). Formal questions can be send to Nancy Sabaditsch (email@example.com).
When applying, please use the following email subject title: TIPAT ESR2 - Your Name
In your application please include the following files:
- A motivation letter (1 page maximum), please include in your letter alternative ESR TIPAT positions of interest to you if not selected, if any.
- A CV according to the Europass format
- Two reference letters (at least one from your Master thesis supervisor)
- An up-to-date of grades in your bachelor and master programs
Optional: English proficiency test results (TOEFL, IELTS)
The application deadline is May 20, 2020. We may extend this deadline depending on the developments of the COVID19 pandemic.
This project has received funding from the European Union's Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No 861323.
- The successful candidates will receive a 36-month, full-time employment contract as per Marie Skłodowska-Curie Actions (MSCA) regulations for early stage researchers. The monthly salary will be confirmed upon offer.
- In addition to their individual scientific projects, TIPAT ESRs will collaborate with world-leading research groups and industries within the consortium through secondments. All ESRs will benefit from further extensive and varied continuing education, completing a series of carefully designed training modules and transferable skills courses; they will participate in symposia, workshops, and international conferences and will have meaningful exposure to the industrial environment through TIPAT industrial partners.
- At the time of commencing their employment, researchers must not have resided or carried out their main activity (work, studies, etc.) in the country of their (recruiting) host organization for more than 12 months in the 3 years prior to their recruitment.
- Applicants must be in the first four years (full-time equivalent research experience) of their research career and have not been awarded a doctoral degree at the first day of their employment contract. This research experience is measured from the date when they obtain the degree which formally entitles them to embark on a doctorate (either in the country in which the degree was obtained or in the country in which the researcher is recruited), even if a doctorate was never started or envisaged. Research experience is measured to the first day of the employment contract of the researcher.
- Usual MSCA eligibility criteria apply and will be verified during the application process. For more information on MSCA, please see: http://ec.europa.eu/mariecurieactions. Benefits
The application procedure is as follows:
- A notification for receiving your application is send after the application deadline.
- Applicants are notified if they are invited for video-conferencing interviews by May 30
- Interviews are schedule to be completed by June 15
- Hiring process is completed by June 30
Please note these dates may change if the application deadline is Extended.
REQUIRED EDUCATION LEVELMedical sciences: Master Degree or equivalent
- Master degree in the field of Medicine or Pharmacy (graduation before project start date)
- Experience in in-vitro work, clinical studies
- Good communication and interpersonal skills to organize research with both academics and professionals;
- Good communication (verbal and writing) skills in English;
- Good communication (verbal and writing) skills in German;
- Confirmed capacity to write high-level scientific reports and papers;
- Interested in participating in educational tasks;
- Independent and creative team player
EURAXESS offer ID: 513736
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