26/03/2020

PhD position: Unraveling the role of neuroendocrine cells in neuronal hyperexcitability in non-allergic airway diseases.


  • ORGANISATION/COMPANY
    KU Leuven
  • RESEARCH FIELD
    Other
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
  • APPLICATION DEADLINE
    01/08/2020 23:59 - Europe/Brussels
  • LOCATION
    Belgium › Leuven
  • TYPE OF CONTRACT
    To be defined
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    38
  • REFERENCE NUMBER
    BAP-2020-190

Airway hyper reactivity (AHR) is a common clinical feature of both upper and lower airway inflammation, characterized by mucosal responses to environmental stimuli that do not evoke responses in healthy individuals. Airway hyper reactivity is the result of increased sensitivity of afferent neurons in the airways to cold air, pollutants and/or bacterial components. However, the mechanisms responsible for AHR are not well understood. Thanks to the development of single cell RNA sequencing, a novel epithelial cell type, i.e. neuro endocrine cells, have been described in the airways. These cells are equipped with chemo sensors that can be activated by pollutants, cold air and bacterial components. The role of these cells in non-allergic airway diseases, and whether these cells contribute to AHR has not been explored. The goal of this project is to explore the role of these newly identified neuro endocrine cells in the pathology of non-allergic airway diseases, and their contribution to AHR. 

Benefits

We offer:• a full time appointment (100%) as a PhD student for a period of 4 years, of which the first three years are covered by internal research funding (3M180292) and the fourth year by the hosting research group. In the meantime, the candidate will be encouraged to apply for an FWO doctoral mandate. • Membership of a world-renowned laboratory in airway diseases, as part of a motivated interdisciplinary team, with an extensive international network. • The possibility to participate and present own research at national and international conferences

Eligibility criteria

• Master’s degree (with high grades) in Medicine, Biomedical Sciences, Bio-engineering or similar • An inquisitive and creative mind, good problem-solving skills• Ambition to start and engage in research, with perseverance to bring the PhD project to a successful defense of the PhD project at KU Leuven• Proven proficiency in English, both written and orally• Strong writing and analytical skills• Good communication and organization skills• Ability to meet deadlines • Capacity to work both as an independent researcher and as part of a team• Team player

Selection process

For more information please contact Mr. Brecht Steelant, tel.: +32 16 32 19 16, mail: brecht.steelant@kuleuven.be or Prof. dr. Peter Hellings, tel.: +3216332342, mail: peter.hellings@kuleuven.be.
You can apply for this job no later than 01/08/2020 via the online application tool

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Work location(s)
1 position(s) available at
Katholieke Universiteit te Leuven
Belgium
Leuven
3000

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EURAXESS offer ID: 508405

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