19/02/2020

Two postdoc positions on developing novel probes and their application in cells

This job offer has expired


  • ORGANISATION/COMPANY
    DWI - Leibniz Institute for Interactive Materials
  • RESEARCH FIELD
    ChemistryBiochemistry
    PhysicsBiophysics
  • RESEARCHER PROFILE
    Recognised Researcher (R2)
  • APPLICATION DEADLINE
    16/04/2020 23:00 - Europe/Brussels
  • LOCATION
    Germany › Aachen
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    40

We have two vacancies for postdocs with a keen interest in the creative design of new (bio)molecular probes and their application in various cell types.

The intracellular environment is characterized poorly due to its high molecular density and heterogeneity, both in space and time. This environment is, however, the fundament of the biochemical organization that governs the cell. The best method to characterize the intracellular environment on the level of physicochemistry, biochemistry, and small molecules, is to employ molecular probes.

In this project, you will

  • Design, fabricate, and test novel (protein, polynucleotide, or small-molecule- based) probes.
  • Determine critical parameters that govern the in vivo environment in various model organisms using the new probes.
  • Relate your findings to medical relevant scenarios.
  • Work closely with Ph.D. students and support their existing projects.
  • Develop your research project and ideas.

Your profile:

  • You completed a successful Ph.D. in biophysics, chemical biology, biochemistry, or related field.
  • You have a high affinity for the creative design of molecules, the understanding of the in vivo environment, and the translation of fundamental research to relevant applications.
  • You should have excellent communication skills. You step up and share knowledge.
  • You have the ability to work in research projects driven by a dynamic international research team.
  • You are proficient in English, both spoken and written.

This research is funded by an NWO Vidi grant and will be executed in the Boersma group at the DWI-Leibniz Institute for Interactive Materials in Aachen. The institute has excellent infrastructure for multidisciplinary research, which include microfluidics, organic/polymer chemistry, mammalian/bacterial cell culture, and a wide array of measurement methods such as confocal, STED, electrophysiology, etc. Further, the institute has close connections with the nearby University Medical Center and constructs a novel "first in translation" building in the next years, which eases the development of medical devices. The institute has a strong collaborative mentality. The Boersma group builds synthetic systems from biological parts for advanced functions, such as probes and diagnostic tools. The lab has been especially successful in recent years on FRET sensor development with the first sensors for the macromolecular crowding and ionic strength. The group operates on the interface of biophysics, synthetic biochemistry, and organic chemistry.

Further information on the group and institute can be found at:

www.boersmalab.com

https://www.dwi.rwth-aachen.de/en/person/dr-arnold-boersma

Interested? This vacancy is open until 16 March 2020. Please send your application including CV, contact details of two references, and motivation letter in a single pdf to:

Dr. Arnold J. Boersma

boersma@dwi.rwth-aachen.de

Work location(s)
2 position(s) available at
DWI - Leibniz Institute for Interactive Materials
Germany
Aachen
52056
Forckenbeckstr. 50

EURAXESS offer ID: 494937

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