12/02/2020
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ESR10 - Early Stage Researcher/PhD Position in biomechanics: Tissue characterization and endovascular aortic repair in a circulatory mock loop

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  • ORGANISATION/COMPANY
    Fondazione Toscana Gabriele Monasterio per la Ricerca Medica e di Sanità Pubblica CNR - Regione Toscana
  • RESEARCH FIELD
    EngineeringBiomedical engineering
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
  • APPLICATION DEADLINE
    15/03/2020 17:00 - Europe/London
  • LOCATION
    Italy › Massa
    France › Saint-Étienne
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    40
  • OFFER STARTING DATE
    01/04/2020
  • EU RESEARCH FRAMEWORK PROGRAMME
    H2020 / Marie Skłodowska-Curie Actions
  • REFERENCE NUMBER
    MEDITATE ESR10
  • MARIE CURIE GRANT AGREEMENT NUMBER
    859836

OFFER DESCRIPTION

Early Stage Researcher (ESR) PhD position in biomechanics within the framework of the project MeDiTATe (The medical digital twin for aneurysm prevention and treatment) funded by the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie Actions (MSCA) Innovative Training Networks (ITN) with Grant Agreement No. 859836.

MeDiTATe is a European Industrial Doctorate (EID). The whole project aims to develop state-of-the-art image based medical Digital Twins of cardiovascular districts for a patient specific prevention and treatment of aneurysms.

 

 

 The aim of this ESR programme is to develop a mock loop for in-vitro testing and in-silico model for ascending thoracic aortic aneurysm treatment to (i) validate the endovascular procedure and (ii) to analyse the effect of endograft implant in the fluid-dynamic environment by CFD. For the achievement of the objectives, 4 phases of the research activities are planned: mechanical characterization of aneurysmatic vessel tissue for ascending thoracic aortic district, morphological assessment of patient specific models for aneurysms, in-vitro simulation of the surgical implant with fluid-dynamic characterization through the mock loop and in-silico simulation of the surgical implant. For the first phase an ex-vivo fresh specimen is gathered from patient undergoing selective surgical procedure according to the best clinical practice, then a mechanical characterization (uniaxial/biaxial traction tests) is achieved and experimental data extraction and fitting via constitutive model with particular attention to anisotropic behaviour is carried. The second phase foresees a patient-specific images and data extraction from clinical FTGM Database, image post-processing and segmentation for morphology definition and additive manufacturing of patient-specific models (rigid in a first step and then compliant according to experimental data). For the third phase the simulation of the implant deployment is carried and the evaluation of the implant performances on the patient-specific model by extracting the resulting experimental data (pressures, flows, etc.) is achieved. Last phase is completed by carrying CFD Simulations before, after and during endograft deployment and validating and comparing numerical results with experimental data from in-vitro simulation. 

More Information

Benefits

The selected candidate will receive a salary in accordance with the MSCA regulations for ESR. The gross salary includes a living allowance (€3,270 per month, subject to MSCA country correction coefficient, i.e. 104.4 % for Italy and 115.7% for France), a mobility allowance (€600 per month), and a family allowance (€500 per month, if the researcher has family by the date of recruitment, regardless of whether the family will move with the researcher or not). The guaranteed funding is for 36 months (i.e. EC funding). 

Eligibility criteria

Applicants can be of any nationality and must hold a Master of Science degree (or equivalent) in engineering. They need to fully respect both eligibility criteria (to be demonstrated in the Europass CV): (a) Early-Stage Researchers (ESRs) must, at the date of recruitment by the beneficiary, be in the first four years (full-time equivalent research experience) of their research careers and have not been awarded a doctoral degree. (b) Conditions of international mobility of researchers: Researchers are required to undertake trans-national mobility (i.e. move from one country to another) when taking up the appointment. At the time of selection by the host organization, researchers must not have resided or carried out their main activity (work, studies, etc.) in Italy for more than 12 months in the 3 years immediately prior to their recruitment. Short stays, such as holidays, are not taken into account. 

Selection process

Send CV, cover letter, BSc and MSc degrees, and letters of recommendation to all the following recipients: avril@emse.fr, simona.celi@ftgm.it and david.perrin@predisurge.com

Additional comments

ESR10 will be enrolled in the PhD programme of University of Lyon at Mines Saint-Etienne, France. The PhD thesis will take place at 2 different places: (a) Fondazione Toscana Gabriele Monasterio per la Ricerca Medica e di Sanità Pubblica (Italy), public entity specialized in healthcare and research activities of interest to the public health services (for pediatric and adult patients) in the field of cardiology, cardio-surgery, electrophysiology and for the treatment of cardiopulmonary diseases. FTGM performs interventional hemodynamics, heart surgery for neonatal, pediatric and adult patients, anesthesia and intensive therapy for neonatal, pediatric, and adult patients, advanced diagnostic imaging: radiodiagnostics, nuclear medicine, cardiac magnetic resonance, and laboratory medicine; (b) Predisurge, Saint Étienne (France) which aims at developing software solutions to achieve better training, preoperative planning and intervention in the cardiovascular domain. Predisurge is a spin-off of Mines Saint-Etienne (France) and is based in the CIS department, which conducts major international research projects in the field of soft tissue biomechanics, in particular aortic aneurysms. ESR10 will collaborate with other researchers of CIS involved in ERC projects (https://www.mines-stetienne.fr/en/author/avril/, https://www.emse.fr/~badel/). A one-month secondment will take place at Università Degli Studi di Roma Tor Vergata (Italy). 

Offer Requirements

  • REQUIRED EDUCATION LEVEL
    Engineering: Master Degree or equivalent
  • REQUIRED LANGUAGES
    ENGLISH: Excellent

Skills/Qualifications

Candidates with background in Computational and Experimental Fluid Mechanics should apply for this position. Motivation and interest in Computer Modeling, Biomedical engineering and Experimental Work is preferable. 

Work location(s)
1 position(s) available at
Fondazione Toscana Gabriele Monasterio per la Ricerca Medica e di Sanità Pubblica
Italy
Massa
1 position(s) available at
PrediSurge
France
Saint-Étienne

EURAXESS offer ID: 491971

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