20/01/2020

Post-doctoral position

This job offer has expired


  • ORGANISATION/COMPANY
    KU Leuven
  • RESEARCH FIELD
    Biological sciencesBiological engineering
    Biological sciencesBiology
    Medical sciences
  • RESEARCHER PROFILE
    Recognised Researcher (R2)
  • APPLICATION DEADLINE
    15/12/2021 23:00 - Europe/Brussels
  • LOCATION
    Belgium › Leuven
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    38

OFFER DESCRIPTION

Context: A post-doctoral position in the context of a KU Leuven competitive funding ID-N (interdisciplinary) project is available in the Endothelial Cell Biology Research Unit, headed by Prof. Dr. Aernout Luttun, at the Center for Molecular and Vascular Biology, Department of Cardiovascular Sciences, KU Leuven, Belgium. This interdisciplinary project is executed by a collaborative and highly interactive network of three different KU Leuven labs that have a broad diversity of technologies available. This post-doctoral position will therefore offer the possibility to gain proficiency in various aspects of the behavior of endothelial cells, including transcriptional regulation, mechanosensing and interaction with their surrounding matrix.

Background and aims of the project: All organs, with a few exceptions, contain a blood vessel network that is adapted to fulfill the needs of the host tissue. Endothelial cells lining the inside of these vessels have therefore acquired specific molecular, morphologic and functional characteristics that become compromised when exposed to disease conditions. Unraveling the mechanisms that determine these organ-specific endothelial characteristics offers the possibility to develop novel strategies to diagnose and treat organ-specific vascular diseases. The current project focusses on endothelial cells in three vital organs, heart, liver and brain. The host lab identified transcription factor combinations highly enriched in endothelial cells in each of these organs. These transcription factors combined with different environmental cues determine the unique properties of endothelial cells in each organ. The central aim of this interdisciplinary project is to estimate the relative contribution of transcription factors and environmental signals to the heterogeneous nature of endothelial cells. This will be accomplished by artificially altering transcription factor expression or by changing their environment through variation of their hemodynamic and mechanical environment. The identification of relevant combinations of transcriptional and environmental modulators of organ-specific endothelial cell phenotypes can inform tissue engineers of the important characteristics to include in the design of organ-specific vascular bed repair strategies.

Responsibilities:

● you will have a dedicated project related to the aims described above and be responsible for its administration and execution

● you will be collaborating with other team members working on endothelial heterogeneity in the host lab and also with colleagues working in the other two labs participating in this ID-N project

● your project will involve working with cells derived from different species (including transgenic mice and human donors) and will encompass their isolation and culture, their manipulation by lentiviral overexpression of transcription factor (combination)s or by altering cell environment (through exposure to flow, native extracellular matrix or artificial matrices with different degrees of stiffness); an important part of the work will be related to expressional and functional profiling of the (manipulated) cells

● you will be expected to present your work at internal and external (inter)national meetings

More Information

Benefits

The position is available for one or two years, pending satisfactory progress. The candidate is however expected to compete for a post-doctoral scholarship during the first year. The position will be further extended if a scholarship is obtained.

Eligibility criteria

Candidates must have a PhD degree and hold a certificate to work with laboratory animals.

Selection process

For application, please e-mail your CV including three references. Selected candidates will be invited for an interview.

Additional comments

Starting date of the position is flexible.

Required Research Experiences

  • RESEARCH FIELD
    Biological sciencesBiology
  • YEARS OF RESEARCH EXPERIENCE
    4 - 10

Offer Requirements

  • REQUIRED EDUCATION LEVEL
    Biological sciences: PhD or equivalent
  • REQUIRED LANGUAGES
    ENGLISH: Excellent

Skills/Qualifications

Candidates need to have a PhD degree in a relevant discipline (e.g., Biological Sciences) and have a background and experience in preferably multiple aspects mentioned in the project description. We seek a highly motivated and enthusiastic individual with good communication and writing skills in English and the ability to guide and supervise (a) PhD student(s). A general good proficiency in molecular and cellular biology techniques (including qRT-PCR, RNAseq (including analysis), Western blot, ChIP, lentivirus production and cell transduction, FACS, cell culture), histology and (confocal) microscopy, (transgenic) animal models is an important asset. A good publication record with a least one publication in a higher-impact journal will be valued.

Specific Requirements

Candidates will be expected to apply for a grant to support their salary during (part of) their tenure.

Work location(s)
1 position(s) available at
KU Leuven
Belgium
Leuven
BE-3000
Campus Gasthuisberg, Onderwijs en Navorsing 1, Herestraat 49, bus 911

Open, Transparent, Merit based Recruitment procedures of Researchers (OTM-R)

Know more about it at KULeuven - Endothelial Cell Biology Research Unit

Know more about OTM-R

EURAXESS offer ID: 482822

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