05/12/2019
Marie Skłodowska-Curie Actions

2 PhD positions at Eidgenössische Technische Hochschule Zürich (ETHZ)

This job offer has expired


  • ORGANISATION/COMPANY
    Eidgenössische Technische Hochschule Zürich (ETHZ)
  • RESEARCH FIELD
    Chemistry
    Engineering
    Physics
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
  • APPLICATION DEADLINE
    15/01/2020 23:00 - Europe/Athens
  • LOCATION
    Switzerland › Zurich
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    40
  • OFFER STARTING DATE
    01/02/2020
  • EU RESEARCH FRAMEWORK PROGRAMME
    H2020 / Marie Skłodowska-Curie Actions
  • MARIE CURIE GRANT AGREEMENT NUMBER
    861145

PhD position 1:

Project Title: Using magnetoelectric nanoparticles to induce cell electrofusion.

Objectives: Synthesis of suitable (biocompatible) core-shell multiferroic NPs by hydrothermal and sol-gel methods; assessment of cytotoxicity and sensitization effects in a custom-built incubator with an integrated set of Helmholtz coils; optimization of magnetic field pulse strength and frequencies to induce cell electroporation and electrofusion; assessing effects of osmolarity of the fusion medium; patch clamp electrophysiological analyses; finite element modelling of cells in contact exposed to electric fields (Comsol Multiphysics, including a model for electroporation).

Expected results: Demonstration of electrofusion (high fusion yield) between B16-F1 melanoma cells with Chinese hamster ovary cells; extrapolation to other cell lines with dissimilar sizes (such as in hybridoma technology).

 

PhD position 2:

Project Title: Magnetopyroelectric nanoarchitectures for anti-cancer drug delivery.

Objectives: Synthesis of core-shell magnetopyroelectric structures (hydrothermal + sol-gel techniques): superparamagnetic cores with hyperthermal features surrounded by shells made of a pyroelectric compound, able to generate electric fields upon mild heating; biofunctionalization (model drug: paclitaxel); patch clamp ion-channel electrophysiological studies magnetoelectrically-driven drug release on human breast and/or ovarian carcinoma cells; pharmacokinetics studies.

Expected results: Effective loading of ME NPs with paclitaxel (avoiding premature release); selective drug delivery on carcinoma cells (and not on normal cells), mediated by the ME effects, due to the different membrane’s electric properties (smaller threshold for electroporation in cancer cells); drug delivery using energy-efficient conditions (e.g., AC magnetic field 50 Oe, 100–5000 Hz).

 

The Swiss Federal Institute of Technology (ETH) Zurich is one of the world’s leading universities for technology and the natural sciences. It has nearly 18,000 students from over 100 different countries. The Multiscale Robotics Lab (MSRL) belongs to the Institute of Robotics and Intelligent Systems (IRIS) which is part of the ETH Zurich and pursues a dynamic research program that maintains a strong robotics research focus on several emerging areas of science and technology. A major component of IRIS research leverages advanced robotics for creating intelligent machines that operate at micron- and nanometer scales. MSRL research develops the tools and processes required to fabricate and assemble micron sized robots and nanometer scale robotic components. Many of these systems are used for robotic exploration within biological domains, such as in the investigation of molecular structures, cellular systems, and complex organism behavior (http://www.msrl.ethz.ch).

BeMAGIC project is a Marie Sklodowska-Curie Innovative Training Network that offers the possibility to pursue the PhD within the Network at different universities/research centres/companies across Europe. The duration of the appointment is 3 years, starting in February 2020.  Importantly, the Marie Curie eligibility criteria must be respected. Eligible early-stage researchers (ESRs) are those who are, at the date of recruitment by the host institution, in the first four years (full-time equivalent) of their research careers. This is measured from the date when they obtained the degree which would formally entitle them to embark on a doctorate. In addition, researchers must not have resided or carried out their main activity (work, studies, etc.) in the country of the host organization for more than 12 months in the 3 years immediately prior to their recruitment. Researchers can be nationals of any country (including all countries outside Europe).

Application procedure: Interested applicants should provide a full CV and a letter of interest on the following website: https://bemagic-etn.eu/project/offered-esr-positions

Work location(s)
2 position(s) available at
Eidgenössische Technische Hochschule Zürich (ETHZ)
Switzerland
Zurich

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EURAXESS offer ID: 470063

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