INsTRuCT: Call for applications from Early Stage Researchers for 15 Doctoral (PhD) Training Positions in Basic, Translational and Computational Immunotherapy
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ORGANISATION/COMPANYUniversity Hospital Regensburg
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RESEARCH FIELDBiological sciences › OtherComputer scienceMedical sciences › OtherPharmacological sciences › Other
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RESEARCHER PROFILEFirst Stage Researcher (R1)
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APPLICATION DEADLINE31/01/2020 23:00 - Europe/Brussels
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LOCATIONMultiple locations, see work locations below.
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TYPE OF CONTRACTTemporary
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JOB STATUSFull-time
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HOURS PER WEEK40
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OFFER STARTING DATE01/09/2020
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EU RESEARCH FRAMEWORK PROGRAMMEH2020 / Marie Skłodowska-Curie Actions
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MARIE CURIE GRANT AGREEMENT NUMBER860003
INsTRuCT is an Innovative Training Network (ITN) funded by the European Union Horizon 2020 Programme. The INsTRuCT Consortium is a research network of leading European scientists from academia and industry focused on fundamental research and clinical translation of myeloid regulatory cell (MRC)-based immunotherapies. A total of 15 doctoral research projects (PhD projects) for Early Stage Researchers (ESR) are offered across 13 institutes in Europe. Research topics range from fundamental to translational science, all at the forefront in the field of MRC-based immunotherapies. Successful applicants will also receive expert training in basic immunological research, preclinical pharmacological development, manufacturing processes, clinical trial design, healthcare economics, ethics and marketing. The interaction of biologists, computational scientists, physicians and engineers is central to INsTRuCT and will challenge ESR to explore complex issues in bench-to-bedside research from different perspectives. Graduates of INsTRuCT will be well-prepared to enter the workplace with an innovative and beyond state-of-the-art view on fundamental and translational science of cell-based therapies that will accelerate the future of the field.
Participating in INsTRuCT offers early stage researchers many unique opportunities, including:
- A project as Marie Skłodowska Curie trainee in one of the participating institutions with the intention of receiving a doctoral degree (PhD).
- State-of-the art, exciting research in an international consortium with highly integrated research projects.
- Expert training in preclinical and clinical development of cell-based medicinal products.
- At least two months of research training in the lab of another consortium member, mostly in a different EU country than the country where most of the project will take place.
- Training in both academic and commercial research environments.
- Salary according to EU guidelines for Marie Skłodowska Curie trainees, including mobility payments and family allowances where applicable.
Eligible candidates must:
- hold a Master’s degree or equivalent in a field of science relevant to their chosen project (see below)
- demonstrate a history of academic excellence
- demonstrate an affinity for Basic Immunology, Computational Biology, bio(medical / process) engineering or translational research
- speak and write fluently in English
- have less than 4 years’ previous research experience and not hold a doctoral (PhD) title
- have not been resident in the country where the host institution is located for more than 12 months in the 3 years before recruitment.
- be available for a personal interview at the INsTRuCT recruitment meeting in Barcelona, 23-25 March 2020.
- be available to start their project no later than 1st September 2020.
Individual Projects details (find full information on the PDF)
ESR1: Metabolic Programming of Human Monocyte Differentiation
Hosting Institution: Trinity College Dublin, Ireland,
Supervisor: Dr. ZASLONA, Zbignew
Email address for the applications ZASLONAZ@tcd.ie
Subject area: Molecular Immunology; Cellular Metabolism
Project-specific selection criteria: Desirable experience in molecular biology laboratory, preferable experience with techniques, such as Western Blotting, flow cytometry and qPCR. Knowledge of Immunology and in particular innate immunity preferable
ESR2: Mitochondrial and metabolic functions of tolerogenic myeloid cells
Hosting Institution: Charité University Hospital, Berlin, Germany
Supervisor Prof. SAWITZKI, Birgit
Email address for the applications birgit.sawitzki@charite.de
Subject area: Molecular Immunology; Cellular Metabolism
Project-specific selection criteria Experience with primary cell culture, flow cytometry and an interest in bioinformatics / R programming
ESR3: Engineered Tolerogenic Dendritic Cells for Ag-Specific Immunotherapy
Hosting Institution: Ospedale San Raffaele, Milan, Italy
Supervisor Dr. GREGORI, Silvia
Email address for the applications silvia.gregori@hsr.it
Subject area: Molecular & Cellular Immunology; Epigenomics
Project-specific selection criteria: Degree in Biological Sciences, Biotechnology or related disciplines with skills in molecular and cellular biology as well as primary human cell culture and manipulation. The use of FACS/sorter and experience in animal handling is a significant plus.
ESR4: Trained Immunity in Regulatory Macrophages
Hosting Institution: Instituto de Salud, Carlos III, Madrid, Spain
Supervisor Prof. OCHANDO, Jordi
Email address for the applications jordi.ochando@mssm.edu
Subject area: Molecular & Cellular Immunology; Epigenomics
Project-specific selection criteria: Practical experience of common techniques in Molecular Biology and Cellular Immunology.
ESR5: A data science approach to characterising tolerogenic myeloid regulatory cell therapies in a standardised manner
Hosting Institution: Newcastle University, United Kingdom
Supervisors Dr. LORD, Phillip (primary),Dr. HILKENS, Catharien
Email address for the applications phillip.lord@newcastle.ac.uk, catharien.hilkens@newcastle.ac.uk
Subject area: Computational Biology; Data Science
Project-specific selection criteria: As this is a cross-disciplinary project, a Masters degree or equivalent in bioinformatics, or computional biology is preferrable. Also acceptable, a BSc or equivalent in Computing Science, a BioMedical Science (inc. Immunology), with a strong and demonstrable interest in the other discipline. Experience with (some of) knowledge representation, biological data handling, databases or data integration.
ESR6 Investigating molecular mechanisms of human autologous tolerogenic DC
Hosting Institution: University of Nantes, France
Supervisor Dr. MOREAU, Aurélie
Email address for the applications Aurelie.Moreau@univ-nantes.fr
Subject area: Molecular & Cellular Immunology; Cellular Metabolism
Project-specific selection criteria: Master degree in Science, strong knowledge in immunology and experience with (or interest for) bioinformatic tools.
ESR7 Computational characterisation, classification and deconvolution of myeloid regulatory cells
Hosting Institution: University of Regensburg, Germany
Supervisors Prof. REHLI, Michael, Prof. SPANG, Rainer
Email address for the applications michael.rehli@ukr.de, rainer.spang@ukr.de
Subject area: Computational Biology; Transcriptomics
Project-specific selection criteria: Degree in Mathematics, Computer Science, Physics or other project-relevant subject.
ESR8 Development of Pharmaceutical Release Processes for DC-based Therapy
Hosting Institution: Cimaas BV, The Netherlands
Supervisor Prof. GERMERAAD, Wilfred
Email address for the applications w.germeraad@cimaas.com
Subject area: GMP Manufacturing; Quality Control; Cellular Immunology
Project-specific selection criteria: Strong background in Immunology; Interest in product development; main competencies: flexibility, creativity, can-do mentality
ESR9 Personalized MRC-based therapy: innovative strategies to improve efficacy
Hosting Institution: King’s College London, United Kingdom
Supervisors Prof. SANCHEZ FUEYO, Alberto; Prof. LOMBARDI, Giovanna
Email address for the applications sanchez_fueyo@kcl.ac.uk, giovanna.lombardi@kcl.ac.uk
Subject area: Computational Biology; Personalized Medicine
ESR10 Development and validation of antigen-specific assays for T and B cell responses following tolerance-inducing treatments with MRC-based therapies
Hosting Institution: Sanquin Blood Supply and University of Amsterdam, The Netherlands
Supervisors Prof. ten BRINKE, Anja; Prof. van HAM, Marieke
Email address for the applications a.tenbrinke@sanquin.nl, m.vanham@sanquin.nl
Subject area: Cellular Immunology; Personalized Medicine
Project-specific selection criteria: A Master degree in Biomedical Sciences or a similar education level. Knowledge of Immunology is required and a proven track record in research in cellular immunology is a prerequisite. Team player with good communication skills.
ESR11 Development of an affordable & scalable process for tolDC manufacturing
Hosting Institution: University of Antwerp, Belgium
Supervisor Prof. COOLS, Nathalie
Email address for the applications Nathalie.Cools@uza.be
Subject area: GMP Manufacturing; Quality Control; Cellular Immunology
Project-specific selection criteria: Masters degree in Cell Biology, Immunology, Biotechnology, Mechanical Engineering or equivalent qualifications. Practical laboratory experience preferred.
ESR12 Classification of Human Myeloid Regulatory Cell Networks by Machine Learning from Multiparametric Immunofluorescence Images
Hosting Institution: Miltenyi Biotec BV & Co. KG , Bergisch Gladbach, Germany
Supervisor Dr. KOLLET, Jutta
Email address for the applications jutta.kollet@miltenyibiotec.de
Subject area: Computational Biology; Image Analysis
Project-specific selection criteria: Degree in Bioinformatics , Computer Science, or Biology with project-relevant subject.
ESR13: Genes & pathways associated with the tolerogenic capacity of tolDC-VitD3
Hosting Institution: Institute of the Germans Trias i Pujol Foundation, Barcelona, Spain
Supervisor Prof. MARTINEZ CACERES, Eva
Email address for the applications emmartinez.germanstrias@gencat.cat
Subject area: Molecular & Cellular Immunology; Translational Research
ESR14: Therapeutic Targeting of Mreg – T cell Interactions
Hosting Institution: University Hospital Regensburg, Germany
Supervisor Dr. HUTCHINSON, James Alexander
Email address for the applications james.hutchinson@ukr.de
Subject area: Molecular & Cellular Immunology; Immunopharmacology
Project-specific selection criteria: Practical experience of common techniques in Molecular Biology and Cellular Immunology.
ESR15 Route of delivery of tolerogenic dendritic cells
Hosting Institution: University of Newcastle, United Kingdom
Supervisor Prof. ISAACS, John Dr. HILKENS, Catharien
Email address for the applications catharien.hilkens@newcastle.ac.uk john.isaacs@newcastle.ac.uk,
Subject area: Cellular Immunology; Translational Research
Project-specific selection criteria: Master degree in a biological or biomedical science with laboratory experience in immunological techniques
Benefits
ESR will be given an employment contract for 36 months (or 48 months in the case of ESR8, ESR10 and ESR11) by their host institution. ESR will be entitled to full employee benefits and inclusion in social security schemes of the host nation. ESR will be compensated according to the general conditions of the EC Marie Skłodowska-Curie Actions and specifically those conditions relating to ESR participating in ITN.
Eligibility criteria
Experience eligibility requirement:
Eligible applicants must :
- hold a Master’s degree or equivalent in a field of science relevant to their chosen project (see below)
- demonstrate a history of academic excellence
- demonstrate an affinity for Basic Immunology, Computational Biology or translational research
- speak and write fluently in English
- have less than 4 years’ previous research experience and not hold a doctoral (PhD) title
Mobility eligibility requirement: The fellow must not have resided in the country where the research training activities will take place for more than 12 months in the 3 years immediately prior to the recruitment date (and not have carried out their main activity (work, studies, etc.) in that country).
Other requirements:
- be available for a personal interview at the INsTRuCT recruitment meeting in Barcelona, 23-25 March 2020.
- be available to start their project no later than 1st September 2020.
Selection process
INsTRuCT will select ESR through a 2-step recruitment process. Candidates should submit their application for their top two or three preferred research projects. Applications (in English) should include a CV, a Letter of Motivation and a Letter of Recommendation from two appropriate referees. The closing date for applications is January 31st, 2020. Application documents should be sent by email to Mrs. Christine Bayer, Project Administrator (christine.bayer@ukr.de) and the relevant project supervisors by email (see individual project descriptions). Applicants are advised to familiarise themselves thoroughly with projects for which they apply and be ready to answer questions on their chosen topics. After reviewing all project applications, supervisors of individual projects will contact selected applicants to organise an initial screening interview by telephone or videoconferencing. The most promising candidates will then be invited to a personal interview in a recruitment meeting of the whole consortium in Barcelona on 23rd – 25th March, 2020. Approximately half of those interviewed in the second round will be offered a position.
Web site for additional job details
Offer Requirements
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REQUIRED EDUCATION LEVELMedical sciences: Master Degree or equivalentBiological sciences: Master Degree or equivalentPharmacological sciences: Master Degree or equivalentComputer science: Master Degree or equivalent
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REQUIRED LANGUAGESENGLISH: Excellent
Skills/Qualifications
Project-specific background criteria are described for each individual project
Specific Requirements
Project-specific requirements are detailed for each individual project
Job Work LocationEURAXESS offer ID: 470059
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