RESEARCH FIELDBiological sciences › OtherComputer science › Informatics
RESEARCHER PROFILEFirst Stage Researcher (R1)
APPLICATION DEADLINE15/02/2020 23:00 - Europe/Brussels
LOCATIONMultiple locations, see work locations below.
TYPE OF CONTRACTTemporary
HOURS PER WEEK35-40
EU RESEARCH FRAMEWORK PROGRAMMEH2020 / Marie Skłodowska-Curie Actions
MARIE CURIE GRANT AGREEMENT NUMBER861329
14 PhD positions are available in the framework of the Marie Curie Innovative Training Network (ITN) on
Training researchers for Studying Ciliary Signalling in Development and Disease (SCilS)
Primary cilia are microtubule-based projections from the cell surface of nearly every cell in our body. In the last two decades it has become clear that primary cilia have evolved to be key signalling hubs of the cells, as they concentrate or segregate components of major cellular signalling pathways. Dysfunctional cilia can lead to over 35 severe human genetic traits (ciliopathies) with highly heterogeneous, overlapping phenotypes, affecting as many as 1 in 400 people. We now know that humans critically depend on cilia to see, hear, smell, breathe, excrete and reproduce. Such activities require a high degree of regulation and critical feedback to ensure robustness in development and cellular homeostasis of different tissues and organs.
Understanding this multi-level organisation and regulation requires integration of unique expertise, including: structural biology, cryo-electron tomography and 3D reconstruction to study ciliary protein function and dynamics in the highest detail; quantitative proteomics to assess ciliary protein network behaviour upon developmental signalling cues or genetic mutation; (stem) cell biology and biochemistry to deconvolute novel signalling cascades and evaluate existing ones; organoid technology, and zebrafish models to evaluate ciliary signalling in different tissues; and state-of-the-art genomics and bioinformatics to scruinize the effects of genetic variation in ciliopathy patients and identify therapeutic targets.
SCilS has now gathered the required European experts, both scientific and industrial leaders as well as dedicated non-profit organisations that are all motivated to train a new, pan-European cohort of students to become the next generation of independent cilia researchers. These researchers will not only be equipped with unique specializations and skills, but also with a multidisciplinary understanding of ciliary signalling in health and disease, and with important intersectoral experience. This will be achieved by an integrated research and training programme for 14 ESRs, aimed at closing the knowledge gaps in ciliary signalling
SCilS training will give Early Stage Researchers (ESRs) unparalleled training opportunities in outstanding academic and industrial settings through training-by-research via individual research projects, secondments, and network-wide training sessions. All individual training and research activities have been designed to provide each ESR with the necessary broad competences in state‐of‐the art academic and industrial research. The network will thereby make a career in both industry and academia attractive to the ESRs and improve their career prospects in both private and public sectors.
The anticipated start date of employment is between 1 March 2020 and 1 October 2020, and is to be agreed with your supervisor. You will receive an attractive salary including mobility allowance and family allowance (if applicable) as laid down in the Horizon 2020 Marie Skłodowska-Curie actions Work Programme 2018-2020.
- Applicants should be in the first 4 years (full-time equivalent research experience) of their research careers and have not been awarded a doctoral degree. This is measured from the date when a degree that formally entitles you to embark on a doctorate was obtained until the start date of employment.
- Applicants are willing to move to the country of the host institution of interest.
- Applicants should not have resided or carried out their main activity (work, studies, etc.) in the country of the host institution of interest for more than 12 months in the 3 years immediately before the start date of employment. Short stays, such as holidays, are not taken into account.
- You are proficient in written and spoken English.
- You have the requested skills and experience for the PhD project(s) of interest.
How to apply:
Applicants must submit (see application documents)
• a personal statement explaining their motivation and project interests and the contact details of 2 academic referees
• an EU format CV (other formats are NOT accepted)
• a form indicating the preference for one or more specific partner institute(s) and/or research project(s)
Deadline: February 15, 2020, after which we will review applications and interview candidates.
PLEASE NOTE that applications that do not meet the requirements WILL NOT BE CONSIDERED.
After the closing of the application procedure, the local supervisors will evaluate the applications for their PhD project and select candidates for a face-to-face or video interview based on relevant education, scientific skills and experience, motivation and reference letters. Candidates will be asked to give a presentation during the interview. The supervisors will make a final ranking of preferred candidates for their PhD project after the interviews.
Web site for additional job details
REQUIRED LANGUAGESENGLISH: Excellent
Master degree in biomedical sciences, life sciences, chemistry, or computer science/mathematics.
Research experience: Previous experience in cilia/ciliopathy research is not required. Information on your research experience, related to your motivation to apply, must be included with your personal statement (see: application documents)
EURAXESS offer ID: 468255
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