ORGANISATION/COMPANYUniversité Catholique de Louvain, Louvain Drug Research Institute
RESEARCH FIELDBiological sciences › Biological engineeringBiological sciences › BiologyMedical sciences
RESEARCHER PROFILEFirst Stage Researcher (R1)Recognised Researcher (R2)Established Researcher (R3)Leading Researcher (R4)
APPLICATION DEADLINE31/08/2019 00:00 - Europe/Brussels
LOCATIONBelgium › Brussels
TYPE OF CONTRACTTemporary
OFFER STARTING DATE01/10/2019
The BRAF oncogene has recently emerged as a critical regulator of the Warburg phenotype in melanoma, bringing to the fore the importance of metabolic reprogramming in the pathogenesis and treatment of advanced melanoma. Both lactate shuttling and glutamine dependency have been described to drive the metastatic phenotype of melanoma, and to be significant actors of response/resistance in the treatment of melanome, both in response to BRAF or immune checkpoint inhibition. The goal of the current project is to assess the relevance of targeting (i) the lactate shuttling in melanoma xenografts in the context of resistance to BRAF inhibition, and (ii) the glutamine pathway in the context of response to immunotherapy in melanoma, using in vivo state-of-the-art metabolic imaging techniques, namely dynamic monitoring of metabolic fluxes using hyperpolarized (HP) 13C-MRS (magnetic resonance spectroscopy) as well as steady-state assessment of metabolites using high-resolution 13C-MRS.
Funding category: Contrat doctoral
2 ans de financement à commencer au 1er octobre 2019, renouvelable une fois
PHD title: Doctorat en Sciences Biomédicales et Pharmaceutiques
PHD Country: Belgique
The successful applicant must have the following:
•A Master degree in biomedical sciences, pharmacy, biochemistry or similar field, with a mimum average results of 70% (14/20) for the master degree.
•High motivation, curiosity, and commitment to scientific excellence
•Background in cell biology and molecular biology
•Experience in mammalian cell culture
•Knowledge on cellular signaling cascades and regulation mechanisms, immunology, tumor biology, or in vivo experimentation is an advantage
•Interest in imaging and spectroscopy
•Team player skills and enthusiasm to work in a multi-disciplinary, collaborative environment
•Excellent knowledge of the English language
EURAXESS offer ID: 437162
Posting organisation offer ID: 87073
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