14/08/2019

Disrupting lactate shuttling and glutamine pathway in melanoma : relevance of metabolic targeting in combination with BRAF or immune checkpoint inhibitors

This job offer has expired


  • ORGANISATION/COMPANY
    Université Catholique de Louvain, Louvain Drug Research Institute
  • RESEARCH FIELD
    Biological sciencesBiological engineering
    Biological sciencesBiology
    Medical sciences
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
    Recognised Researcher (R2)
    Established Researcher (R3)
    Leading Researcher (R4)
  • APPLICATION DEADLINE
    31/08/2019 00:00 - Europe/Brussels
  • LOCATION
    Belgium › Brussels
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Full-time
  • OFFER STARTING DATE
    01/10/2019

The BRAF oncogene has recently emerged as a critical regulator of the Warburg phenotype in melanoma, bringing to the fore the importance of metabolic reprogramming in the pathogenesis and treatment of advanced melanoma. Both lactate shuttling and glutamine dependency have been described to drive the metastatic phenotype of melanoma, and to be significant actors of response/resistance in the treatment of melanome, both in response to BRAF or immune checkpoint inhibition. The goal of the current project is to assess the relevance of targeting (i) the lactate shuttling in melanoma xenografts in the context of resistance to BRAF inhibition, and (ii) the glutamine pathway in the context of response to immunotherapy in melanoma, using in vivo state-of-the-art metabolic imaging techniques, namely dynamic monitoring of metabolic fluxes using hyperpolarized (HP) 13C-MRS (magnetic resonance spectroscopy) as well as steady-state assessment of metabolites using high-resolution 13C-MRS.



Funding category: Contrat doctoral

2 ans de financement à commencer au 1er octobre 2019, renouvelable une fois

PHD title: Doctorat en Sciences Biomédicales et Pharmaceutiques

PHD Country: Belgique

Offer Requirements

Specific Requirements

The successful applicant must have the following:
•A Master degree in biomedical sciences, pharmacy, biochemistry or similar field, with a mimum average results of 70% (14/20) for the master degree.
•High motivation, curiosity, and commitment to scientific excellence
•Background in cell biology and molecular biology
•Experience in mammalian cell culture
•Knowledge on cellular signaling cascades and regulation mechanisms, immunology, tumor biology, or in vivo experimentation is an advantage
•Interest in imaging and spectroscopy
•Team player skills and enthusiasm to work in a multi-disciplinary, collaborative environment
•Excellent knowledge of the English language

Work location(s)
1 position(s) available at
Université Catholique de Louvain, Louvain Drug Research Institute
Belgium
Brussels

EURAXESS offer ID: 437162
Posting organisation offer ID: 87073

Disclaimer:

The responsibility for the jobs published on this website, including the job description, lies entirely with the publishing institutions. The application is handled uniquely by the employer, who is also fully responsible for the recruitment and selection processes.

 

Please contact support@euraxess.org if you wish to download all jobs in XML.