29/07/2019

PhD student position (m/f/d) in Structural Biology of mRNA regulation

This job offer has expired


  • ORGANISATION/COMPANY
    Goethe University Frankfurt am Main
  • RESEARCH FIELD
    ChemistryBiochemistry
    ChemistryStructural chemistry
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
  • APPLICATION DEADLINE
    13/08/2019 23:00 - Europe/Brussels
  • LOCATION
    Germany › Frankfurt am Main
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Other

OFFER DESCRIPTION

Within the Department of Biological Sciences, Institute for Molecular Biosciences at Goethe University Frankfurt, the lab of mRNA-based gene regulation of Dr. Andreas Schlundt is seeking

a PhD student (E13 TV-G-U, 65%-part time)

with an initial contract duration until September 30 2021, starting as soon as possible.

 

We are investigating the role of mRNA regulatory elements for the recognition by RNA-binding proteins, as a key step for mRNA decay or stabilization. We are focusing on the role of key interactions and the stability of RNA elements by using atom-resolved complex structures as the basis for functional follow-up experiments. We thereby contribute to a broad understanding of different layers in post-transcriptional regulation of gene expression.

 

Within the DFG-funded project “Cis- and trans acting determinants of mRNA structure, stability and fate” you will be responsible for the production and structural/biochemical/biophysical analysis of gene-regulatory RNA-protein complexes using Nuclear Magnetic Resonance Spectroscopy, crystallography, small angle scattering, Cryo-electron microscopy and a broad spectrum of biophysical methods like ITC, SPR and CD spectrometry. Your results will be exploited in permanent mutual exchange with close-by groups for the functional interpretation in cell-biological experiments and thus provide important details for an extended picture of mRNA-protein regulatory landscapes on the molecular level.

 

 

The Johann Wolfgang Goethe University Frankfurt am Main is one of the largest universities in Germany with around 48.000 students and with about 5.000 employees. Founded in 1914 by Frankfurt citizens and since 2008 once again proud of its foundation status, Goethe University possesses a high degree of autonomy, modernity and professional diversity. As a comprehensive university, Goethe University offers a total of 16 departments and a hundred degree programs along with an outstanding research reputation. Goethe University is committed to increase the proportion of women, and suitably qualified women are encouraged to apply. Candidates with disabilities will be given preference in the case of equal qualifications and capacity to complete the project. Durations of employment are subject to the ‘Act of Academic Fixed-Term Contract’ in conjunction with the ‘Hessian Higher Education Act’.

More Information

Benefits

We offer: A position in a growing, dynamic, open-minded and developing research group embedded in a state-of-the-art infrastructure and a network of collaborations throughout the Rhein-Main area. The candidate will be associated with a thematically suitable graduate school and benefit from a broad offer of possibilities for personal development of skills and independence. Frankfurt is a vibrant place located in the heart of Europe and excellently connected to the world. The surrounding Rhein-Main area not only provides quick access to the beautiful nature in an all-year mild climate, but also an extremely dense offer of cultural activities. The position holder will be eligible for free travelling in local public transport and within the full federal state of Hesse.

Selection process

Applications: Please send your application including CV, cover letter, reference contacts and, if applicable, list of publications composed as one pdf file until August 13, 2019 preferably by mail to Dr. Andreas Schlundt, schlundt@bio.uni-frankfurt.de or using the postal address: Institut für Molekulare Biowissenschaften, Max-von-Laue-Straße 9, 60438 Frankfurt am Main. For further questions, please do not hesitate to contact us by mail or telephone number: +49-(0)69-798-29699.

Additional comments

Please see the official job announcement within the GU job portal!

Web site for additional job details

Offer Requirements

  • REQUIRED EDUCATION LEVEL
    Biological sciences: Master Degree or equivalent
    Chemistry: Master Degree or equivalent
  • REQUIRED LANGUAGES
    ENGLISH: Good

Skills/Qualifications

Your profile: An above-average scientific university degree (Diploma or M.Sc.) in Biology, Biochemistry, Chemistry, Biophysics or Biotechnology. Also required are a basic knowledge in the production of recombinant proteins and/or in-vitro transcription of RNA. To complement our team we consider prior experience in crystallography a strong advantage. Alternatively, you provide basic practical experience with solution NMR. Previous knowledge of SAXS/SANS or Cryo-EM is considered a strong plus. You should bring experience with the standard methods of molecular biology and ideally in the application of either ITC, SPR or CD-spectrometry. A further requirement is fast learning, a strong commitment and fluency in English (oral and written).

Specific Requirements

We are expecting an above-average interest in academic research, in particular RNA-protein biochemistry and integrated structural biology. You should be willing to acquire new methodological knowledge. Part of your work will be to publish results and present them on scientific national and international conferences.

 

Work location(s)
1 position(s) available at
Goethe University Frankfurt am Main; IMB
Germany
Frankfurt am Main
60438
Max-von-Laue-Str. 9

EURAXESS offer ID: 432389

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