03/07/2019
Marie Skłodowska-Curie Actions

Early Stage Researcher Position in Targeted Delivery of Therapeutics for Progressive Multiple Sclerosis

This job offer has expired


  • ORGANISATION/COMPANY
    University of Southern Denmark
  • RESEARCH FIELD
    Biological sciencesBiological engineering
    Biological sciencesLaboratory animal science
    Medical sciences
    NeurosciencesNeurobiology
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
  • APPLICATION DEADLINE
    02/08/2019 18:00 - Europe/Brussels
  • LOCATION
    Denmark › Odense C
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    37
  • OFFER STARTING DATE
    01/10/2019
  • EU RESEARCH FRAMEWORK PROGRAMME
    H2020 / Marie Skłodowska-Curie Actions
  • REFERENCE NUMBER
    H2020-MSCA-ITN-2018
  • MARIE CURIE GRANT AGREEMENT NUMBER
    813263
  • IS THE JOB RELATED TO STAFF POSITION WITHIN A RESEARCH INFRASTRUCTURE?
    Yes

An Early Stage Researcher scholarship is available in the laboratory of Professor Trevor Owens, situated at the Department of Neurobiology, Institute of Molecular Medicine, University of Southern Denmark. The position is to be filled by 1 October 2019 or soon thereafter. Application deadline: 02 August 2019

PMSMatTrain is a four-year project, funded by the European Union Horizon 2020 Programme (H2020-MSCA-ITN-2018) under the Marie Skłodowska-Curie Initial Training Network and Grant Agreement No. 813263. The project focuses on gaining a comprehensive understanding of the progressive phase of multiple sclerosis (PMS) from basics to translation, fully supported by eight beneficiaries (six research institutions and two SMEs). This multidisciplinary network will educate and train 15 Early Stage Researchers in device design, biomaterials, materials science, stem cell biology, in vitro, ex vivo and in vivo models of multiple sclerosis, molecular biology, in silico modelling of CSF flow, material functionalisation strategies and device validation.

The Department of Neurobiology in the Institute of Molecular Medicine at SDU is integrated within the Faculty of Health Sciences, associated to basic and clinical research institutes and departments. The Owens laboratory are a Neuroimmunology group who study pathogenic mechanisms of inflammatory diseases of the central nervous system (CNS), such as multiple sclerosis and neuromyelitis optica. We mainly focus to mouse models and we use histological, flow cytometric, molecular and tissue culture methods to evaluate immuno- and neuropathogenesis in genetically-modified mice. We study interactions between the immune system and glial cells of the nervous system, both those that lead to pathology as well as with regulatory and protective outcomes. We are particularly interested in translating clinical observations to experimental analyses and we collaborate with groups in the Region of Southern Denmark and at the Odense University Hospital to understand how innate and adaptive immune cells and mediators contribute to neurological disease. 

The position holder will develop and optimize new technology for controlled and targeted delivery of therapeutic molecules directly to brain cortical tissue. Candidate anti-inflammatory agents and molecules that promote repair and protect neurons will be delivered to animal models of chronic and progressive neuroinflammation, including using functional hyaluronan-based scaffolds. The fellow will make use of advanced histological, cell-sorting, molecular and bioimaging techniques to elucidate the cellular mechanisms underlying neuroprotection.

Programme fellows will experience both public and private sector research & development training and will be best placed to secure employment as high calibre, innovative and well-trained graduates.

Benefits

Salary: The remuneration will be in line with the European Commission rules for Marie Skłodowska-Curie grant holders (Early-Stage Researchers, Initial Training Network). http://ec.europa.eu/research/participants /data/ref/h2020/wp/2018-2020/main/h2020-wp1820-msca_en.pdf.The successful candidate will be enrolled at SDU in accordance with faculty regulations and the Danish Ministerial Order on the PhD Programme at the Universities (PhD order).

Appointment as a PhD Research Fellow is for three years. Employment stops automatically at the end of the period. The holder of the scholarship is not allowed to have other paid employment during the three-year period.

Eligibility criteria

  • Less than 4 years' full time-equivalent research experience
  • Has not yet been awarded a doctoral degree (PhD)
  • Resided less than 12 months in Denmark in the last 3 years.

Selection process

Application must be made in the form of a Declaration of Interest including the following:

• A letter stating your specific interest, motivation and qualifications for the project in question (max. two pages)

• Detailed CV using the Europass template https://europass.cedefop.europa.eu/editors/en/cv/compose, including personal contact information

• Copies of diplomas, Bachelor as well as Master’s degree, including transcript of notes/grades

• At least two signed reference letters. Should your referees wish to send their letters directly to us, please have them use e-mail, mentioning your name and the title of the position in the subject line. And please note that these also need to reach us before deadline.

Shortlisted candidates may be asked to provide a research proposal/description of approach to the above project (max one page excluding references) - Interviews will be held in the last week of August

We welcome applications from all qualified candidates regardless of personal background.Incomplete applications and applications received after the deadline will neither be considered nor evaluated. This also applies to reference letters.

Additional comments

Further information for international applicants about entering and working in Denmark.

Required Research Experiences

  • RESEARCH FIELD
    Biological sciencesBiology
  • YEARS OF RESEARCH EXPERIENCE
    1 - 4

Offer Requirements

  • REQUIRED EDUCATION LEVEL
    Biological sciences: Master Degree or equivalent
  • REQUIRED LANGUAGES
    ENGLISH: Excellent

Skills/Qualifications

Qualifications: Essential

  • MSc level education in neurobiology, immunology, biomedicine, and similar areas.
  • Excellent communication and organisation skills
  • Fluent in spoken and written English
  • Excellent writing and presentation skills
  • Flexibility and ability to work in a team environment
  • Availability to travel nationally and internationally two to three times a year
  • Qualifications: Desirable

  • Experience with in vivo research
  • Experience with outreach events
  • A keen interest in pursuing translational research in multiple sclerosis.

Specific Requirements

Duties and Responsibilities:

The successful candidate will be a fellow of the PMSMatTrain Network, whose research will develop a multi-modal functionalised hydrogel to modulate inflammation, re-myelination and neuroprotection, and assess the bioactivity and efficacy (myelination-boosting potential) of the released compounds on 3D ex vivo cortical brain slices cultures and using mixed brain cell cultures.

In collaboration with other consortium researchers, the fellow at SDU will investigate the efficacy of this platform in different in vivo models of multiple sclerosis, identify candidate biomarkers of re-myelination and repair, and develop protocols for the scale up of the optimised device in collaboration with research fellows in the private sector. 

The successful candidate will:

  • Register for a PhD in the Faculty of Health Sciences at SDU
  • Participate in training events for researchers and Principal Investigators involved in the programme.
  • Liaise and report to the Project Manager, which includes contributing to periodic scientific reports.
  • Contribute to the reporting of project milestones and deliverables in accordance with EU deadlines.
  • Promote and disseminate results from the programme, which includes contributing to newsletters and participating in outreach events.

Further information about the PhD-study can be found at https://www.sdu.dk/en/forskning/phd/phd_skoler/phdskolensundhedsvidenskab

Work location(s)
1 position(s) available at
University of Southern Denmark
Denmark
Odense C
5000
JB Winsloewsvej 25

EURAXESS offer ID: 423554

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