19/06/2019
The Human Resources Strategy for Researchers

PHD STUDENT IN BIOLOGY (H/F)

This job offer has expired


  • ORGANISATION/COMPANY
    CNRS
  • RESEARCH FIELD
    Biological sciencesBiology
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
  • APPLICATION DEADLINE
    10/07/2019 23:59 - Europe/Brussels
  • LOCATION
    France › MARSEILLE 09
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    35
  • OFFER STARTING DATE
    01/10/2019

The project is a transdiciplinary project. Its fruitful management and realization relies not only on the control and the implementation of various concepts and techniques (chemistry, cell biology, ecology and evolution) but also on the ability of communication of different institutes (mainly IMBE and IBDM , and also MIO and CEREGE) with complementary skills. The student will be directed by Carole Borchiellini, Emmanuelle Renard and André Le Bivic and will benefit of an ad hoc Phd committee composed experts in ecotoxicology and chemistry.
The IBDM (http://www.ibdm.univ-mrs.fr/fr/) is located on the Campus Luminy. The IMBE (https://www.imbe.fr/) is dispatched on 6 sites, The PhD student will mainly be located at the marine station (Endoume 13006) but will have to go to other sites (notably Luminy) for experiments (chemistry, imaging) and for meetings.
Both the IBDM and IMBE are under the control of two institutions : CNRS and Aix-marseille university.

Epithelia are cell layers critical for achieving vital physiological functions. The loss of epithelial integrity can therefore result in pathologies or letality. Some epithelial cell types (external or involved in key exchanges with the external environment) are strongly exposed to pollutants.
Metallic pollutions result from various human activities and are a major problem in all ecosystems. But the impact on the whole fauna and marine ecosystems is far from being well described. Ecotoxicological studies often focus on commercial species because of risks for human health. While it is well known that metals trigger oxidative stress in organisms, the cellular and molecular mechanisms disturbed are often insufficiently understood.
The PhD projects aims at understanding the impact of chosen pollutants on cellular and molecular processes, the project will focus on:
1) Epithelial integrity (monitored by epithelial-mesenchymal transition, epithelial protein localization, wound healing and regeneration efficiency)
2) On the homoscleromorph sponge Oscarella lobularis chosen for ecological, evolutionaty and practical reasons
3) Mainly on mercury, lithium (and cadmium) because the literature mention their impact on the disregulation of two key signaling pathways (Wnt and Notch)

We are searching for a highly motivated and enthusiast student interested in both cell mechanisms and environmental questions. The applicant must have obtained a master degree in biology or ecology and should have a strong background in several domains (chemistry, ecology, cell and molecular biology) and be highly interested and motivated by transdisciplinary approaches.
MAIN ACTIVITIES
- Handling biological samples : marine sponges
- Chemical analyses of sediments and sponge samples
- Ecotoxicological experiments (LC 50)
- Molecular biology: RNA extraction; cDNA synthesis, PCR; real time PCR
- Cell biology: cell staining, protein immunolocalization, confocal imaging, histology
- Informatics tools: office, statistic, bioinformatics tools
- Planning and performing of experiments
- Objective analyses of results
- Presenting results via reports or talks in English or French
- Searching and reading bibliography
- Handling biological samples : marine sponges
- Chemical analyses of sediments and sponge samples
- Ecotoxicological experiments (LC 50)
- Molecular biology: RNA extraction; cDNA synthesis, PCR; real time PCR
- Cell biology: cell staining, protein immunolocalization, confocal imaging, histology
- Informatics tools: office, statistic, bioinformatics tools
- Planning and performing of experiments
- Objective analyses of results
- Presenting results via reports or talks in English or French
- Searching and reading bibliography
SKILLS
- team spirit
- easy communication
- strong background in cell and molecular biology
- basic knowledge in evolutionary biology, ecology, bioinformatics, ecotoxicology and environmental chemistry
- being attracted and being at ease with the management of a transdisciplinary project
- English and French speaking, reading and writing
- capability of learning and adapting new techniques
- motivation, seriousness, strictness, obstinacy
- respect of health and safety rules.

Additional comments

Cover letter and CV have to be posted on the WEBSITE “Portail emploi CNRS.
To applicate to this PhD project, you must provide: a cover letter; a full curriculum vitae providing details about the concepts and techniques mastered (especially during your master intership); marks obtained during master 1 and master 2; at least one letter of recommendation and names of two person that may be able to recommend you.

Web site for additional job details

Required Research Experiences

  • RESEARCH FIELD
    Biological sciences
  • YEARS OF RESEARCH EXPERIENCE
    None
  • RESEARCH FIELD
    Biological sciencesBiology
  • YEARS OF RESEARCH EXPERIENCE
    None

Offer Requirements

  • REQUIRED EDUCATION LEVEL
    Biological sciences: Master Degree or equivalent
  • REQUIRED LANGUAGES
    FRENCH: Basic
Work location(s)
1 position(s) available at
Institut de Biologie du Développement de Marseille
France
MARSEILLE 09

EURAXESS offer ID: 419127
Posting organisation offer ID: 10282

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