PhD Position focusing on cytokine-induced metabolic rewiring of the liver in chronic viral infections (INITIATE project ESR 12)

This job offer has expired

    Research Center for Molecular Medicine (CeMM), ÖAW
    Biological sciences
    Medical sciences
    First Stage Researcher (R1)
    Recognised Researcher (R2)
    Established Researcher (R3)
    Leading Researcher (R4)
    15/07/2019 23:59 - Europe/Brussels
    Austria › Vienna

INITIATE (Innate-Immunometablism as Antiviral Target) is an Innovative Training Network funded by the European Commission with the goal to train a new generation of young researchers in the emerging field of antiviral immunometabolism (https://initiate-itn.eu/). Viral outbreaks and epidemics continue to impose high mortality and morbidity burdens on mankind and animals, thus emphasizing the urgent need for improvement and innovation in the development of new antiviral strategies. While it is clear that viral replication, metabolic pathways and host immune responses are tightly interconnected, the molecular pathways and impact on viral pathogenesis are not well-defined and will be the focus of INITIATE. A detailed understanding of the role of metabolic regulation of the host innate immune response with regard to antiviral response and inflammation, together with knowledge of the strategies used by viruses to exploit these pathways, will fundamentally change clinical intervention in the treatment of pathogenic viral diseases.

INITIATE brings together world leaders in virology, inflammation, innate immunity and immunometabolism to educate a new generation of research scientists with interdisciplinary expertise in virology, immunology and immunometabolism. INITIATE includes partners from 7 academic institutes and 3 industrial partners from 7 countries. The consortium will host 15 PhD students – Early Stage Researchers (ESRs), each performing an individual research project at one of the partners. One of these vacant PhD positions (ref. project ESR 12) is available in the research group of Dr. Andreas Bergthaler, Principal Investigator at CeMM, Research Center for Molecular Medicine of the Austrian Academy of Sciences, in Vienna.

*Title of the PhD project:* Investigation of cytokine-induced metabolic rewiring of the liver in chronic viral infections
*Primary supervisor:* Dr. A. Bergthaler, The Research Center for Molecular Medicine (CeMM), Vienna, Austria
*Collaborators:* Prof. C. O`Farrelly (Trinity College Dublin, Ireland); Dr. N. Manel (Stimunity, Paris, France)

Inflammatory processes are tightly linked to metabolic pathways including secreted metabolites and cytokines. The liver is the central organ for metabolism and a hotspot for receiving, processing and distributing local and systemic signals. Yet, comparatively little is known about the metabolic-inflammatory crosstalk at the whole organism level. The proposed PhD project will characterize and delineate interconnected pathophysiological processes with a primary focus on the liver. Systems-level and hypothesis-driven approaches are integrated to identify novel regulatory nodes between metabolism and inflammation. The project will benefit from the combination of benchmark mouse models for chronic infection, cutting-edge technologies such as viral reverse genetics, RNA-seq, metabolomics and metabolite tracing and a multi-pronged focus on systemic immuno-metabolism in vivo. Together with primary cell culture systems and bioinformatic integration of available datasets from other animal models and patients through collaborations and/or the public domain, this project is expected to unravel key parts of the complex interplay between innate cytokine signaling and liver metabolism, which in turn may affect adaptive CD8 T cells and other immune effector cells. Elucidation of the pathophysiological roles of such novel immunoregulatory networks will provide an in-depth mechanistic understanding of pathogen control, inflammation and tissue pathology. This may result in the identification of novel therapeutic targets to ameliorate and/or prevent immunopathologies in infectious and inflammatory diseases.

Type of Contract: Temporary (in total 36 months)
Status: Full-time

Specific Requirements for the project
* Primary honours degree in Biochemistry, Virology, Immunology or related discipline.
* Proficiency in written and spoken English.
* Candidates can be of any nationality but need to demonstrate mobility in terms of moving from one country to another when taking up their appointment. Importantly, candidates must not have resided or carried out their activities – work, studies, etc.- in the country of their host organization (here: Austria) for more than 12 months in the 3 years immediately before August 1st 2019.

Please apply online for project no. ESR 12 with your application documents (cover letter, CV, contact details of references):

Closing date for applications: Jul 15, 2019
Starting date: 15.9.2019

Organisation/Institute Contact Data
Research lab: The Research Center for Molecular Medicine (CeMM), Vienna, Austria
Contact Primary Supervisor: Prof. A. Bergthaler; ABergthaler@cemm.oeaw.ac.at
Website: http://a.bergthaler1.at/

Work location(s)
1 position(s) available at
Research Center for Molecular Medicine (CeMM), ÖAW

EURAXESS offer ID: 418888
Posting organisation offer ID: 693121


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