10/06/2019

PhD student in Laboratory of Structural Bioinformatics

This job offer has expired


  • ORGANISATION/COMPANY
    University of Warsaw
  • RESEARCH FIELD
    Biological sciences
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
  • APPLICATION DEADLINE
    15/07/2019 23:00 - Europe/Brussels
  • LOCATION
    Poland › Warsaw
  • TYPE OF CONTRACT
    Other
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    40
  • OFFER STARTING DATE
    01/10/2019

  1. Description of the position

     

Title of the project:  An evolutionary-based approach to design the substrate specificity of the Rossmann fold enzymes

Project description: The goal of the project is to understand the evolution of the Rossmann fold, one of the most prominent protein folds encompassing enzymes with >300 different functions. With the aid of bioinformatics methods, including machine learning and molecular simulations, we will reveal the principles that define the cofactor specificity in Rossmann enzymes. These principles will be used to build a "toolkit" for rational re-engineering of cofactor specificity. The proposed project involves collaboration with two partners: (i) Core Facility for Crystallography and Biophysics, University of Warsaw (Poland) and (ii) Department of Biomolecular Sciences, Weizmann Institute of Science (Israel).

Requirements:

1. Good knowledge of Python and scientific computing libraries (sci-kit, numpy, pandas, biopython). Experience with high-performance computing and Linux environment

 

2. Previous experience in machine learning and bioinformatics tools (some of the following: protein sequence/structure analysis, protein design, molecular dynamics, phylogenetic analysis)

 

3. Good writing and oral communication skills in English

We offer:

1. An opportunity to participate in a multidisciplinary project conducted in a collaboration with scientists from Poland (University of Warsaw) and Israel (Weizmann Institute of Science)

 

2. The stimulating and very friendly work environment

 

3. Access to the high-end computing equipment (CPU and GPU clusters)

  1. How to apply?

Requiered documents:

1. A copy of a MSc certificate

 

3. A short CV

 

4. A short cover letter

 

5. Contact details of one academic researcher willing to provide a recommendation letter for the Candidate      

Application procedure:

 «ApplicationProcedure»

                s.dunin-horkawicz@cent.uw.edu.pl

                To allow us to process your data, please include the following statement in your application:

“I hereby consent to have my personal data processed by the University of Warsaw with its registered office at ul. KrakowskiePrzedmieście 26/28, 00-927 Warszawa for the purpose of carrying out a recruitment process and selecting an employee and concluding a contract for employment at the University of Warsaw. I have been informed of my rights and duties. I understand that provision of my personal data is voluntary.”

  1. Other

Keywords: Bioinformatics, protein evolution, machine learning

Salary: 4500

Maximum period of contract/stipend: 28 months

Work location(s)
1 position(s) available at
Centre of New Technologies UW
Poland
Warsaw

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EURAXESS offer ID: 415727

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