ORGANISATION/COMPANYUniversity College Cork
RESEARCH FIELDBiological sciencesChemistry › BiochemistryChemistry › Organic chemistry
RESEARCHER PROFILEFirst Stage Researcher (R1)
APPLICATION DEADLINE15/07/2019 17:00 - Europe/London
LOCATIONIreland › Cork
PhD Studentship in Biochemistry and Organic Chemistry
This PhD project is focused on the design, synthesis, physical-chemical characterization and bioanalytical applications of a panel of new multi-functional cell-permeable probes based on phosphorescent Pt-porphyrin dyes. These probes will be specifically tailored for metabolic and multi-parametric assessment and characterization of live mammalian cells and tissue samples in vitro. Their synthesis will involve state-of-the-art organic chemistry and bioconjugation methods, followed by HPLC/LC purification, detailed characterization by MS, NMR, UV-Vis and fluorescence spectroscopy. Applications of the new probes will involve a set of cell based assays, with particular focus on live cell fluorescence microscopy, fluorescence lifetime based sensing and imaging. This project is a continuation of the previous studies performed by the team on new intracellular oxygen-sensing probes and bioanalytical applications thereof (see e.g. Biomater Sci, 2014, 2: 853; Bioconj Chem, 2016, 27: 439). It is also a part of a large multi-disciplinary Biophotonics research theme at the Irish Photonic Integration Centre, IPIC ( www.ipic.ie ), hosted by the Tyndall National Institute and the UCC and funded by the SFI.
Key Duties and Responsibilities
The candidate is expected to be creative, self-motivated and should fit an efficiently and friendly atmosphere of the Biophysics and Bioanalysis lab of Prof. Dmitri B. Papkovsky ( http://www.ucc.ie/en/biochemistry/research/bioanalysis/papkovsky /) and the Organic and Pharmaceutical Chemistry lab of Prof. Anita Maguire ( http://publish.ucc.ie/researchprofiles/V001/amaguire ) and Dr. Stuart Collins ( http://publish.ucc.ie/researchprofiles/D004/stuartcollins ), who will co-supervise the project. This position offers great opportunities for learning and to become internationally visible and to work with external partners in academia and industry.
For further particulars on this studentship please refer to: https://www.ucc.ie/en/hr/vacancies/research/full-details-1023363-en.html
Qualified candidates should send their applications with a covering letter, a CV and names of two academic references - to Prof. Dmitri B. Papkovsky ( firstname.lastname@example.org ) or Prof. Anita Maguire ( email@example.com ) - on or before July 15, 2019.
Early applications are encouraged.
Closing date: July 15, 2019.
- The successful candidate must have a BSc (2.1 or higher) or MSc degree in organic or pharmaceutical chemistry, or background directly relevant to project scope.
- The candidate must demonstrate a high motivation; have an academic record of excellence, good communication and writing skills and ability to learn new experimental techniques.
- Strong theoretical and experimental skills in organic synthesis, bioconjugate chemistry, molecular spectroscopy, particularly fluorescence, NMR, MS, and documented ability of laboratory research.
- Highly self-motivated and able to demonstrate initiative, independent and team work within a multi-disciplinary project team, which includes researches from Biochemistry, Chemistry and Tyndall labs, and to achieve results.
- A commitment to personal development.
EURAXESS offer ID: 415237
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