05/06/2019
The Human Resources Strategy for Researchers

PhD student position on exosome / extracellular vesicles research in tumoral environment


  • ORGANISATION/COMPANY
    Université de Liège (ULg)
  • RESEARCH FIELD
    Biological sciences
    Medical sciences
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
  • APPLICATION DEADLINE
    15/07/2019 09:00 - Europe/Athens
  • LOCATION
    Belgium › Sart Tilman
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    38
  • OFFER STARTING DATE
    01/10/2019

Extracellular vesicles (EV) are small vesicles released by cells in the extracellular milieu that mediate cell-cell communication. EVs have been shown to contain RNA, DNA, lipid and proteins that define a specific repertoire of molecular cargo that are representative of their originating cells. In the context of cancer, EVs are potentially secreted by all cell types that compose in tumor microenvironment (TME). Those vesicles thus represent a new source of regulators of tumor progression.

Our lab has a 10 year-expertise in EV research in angiogenesis related diseases such as cancer. With this new project we aim to unravel the complexity of the EV landscape in pancreas cancer. Our goal is to determine which and how some specific EV released by neoplastic cells as well as from stromal cells impact on tumorigenicity of pancreas cancer. To achieve this goal, we will first characterize the population of EV in a murine model of pancreatic ductal adenocarcinoma (PDAC). Based on their surface markers we will select specific EV populations and determine their role in pancreas cancer pathogenicity. Then, longitudinal studies will be performed to determine the evolution of the EV landscape during PDAC initiation and progression

Offer Requirements

  • REQUIRED EDUCATION LEVEL
    Biological sciences: Master Degree or equivalent
    Medical sciences: Master Degree or equivalent
  • REQUIRED LANGUAGES
    ENGLISH: Good

Skills/Qualifications

We are seeking a highly motivated person with a strong interest in molecular biology. Master degree in molecular biology, biochemistry or biomedical sciences is required. Previous experience in classical molecular biology techniques would be an advantage (qRT-PCR, cell culture assays…) but is not required. Ability to work independently, good communication and enthusiastic personality are skills required to perform this research successfully.

Map Information

Job Work Location Personal Assistance locations
Work location(s)
32 position(s) available at
GIGA Research center
Belgium
Liège
Sart Tilman
4000
avenue de l hopital

EURAXESS offer ID: 414358

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