30/04/2019
Marie Skłodowska-Curie Actions

2 PhD positions at University of Porto (Portugal)

This job offer has expired


  • ORGANISATION/COMPANY
    University of Porto
  • RESEARCH FIELD
    Medical sciencesMedicine
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
  • APPLICATION DEADLINE
    07/09/2019 20:00 - Europe/Brussels
  • LOCATION
    Portugal › Porto
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    40
  • OFFER STARTING DATE
    14/10/2019
  • EU RESEARCH FRAMEWORK PROGRAMME
    H2020 / Marie Skłodowska-Curie Actions
  • MARIE CURIE GRANT AGREEMENT NUMBER
    813716

University of Porto is looking for 2 Early Stage Researchers (ESRs). One ESR (TRAIN-HEART ESR project 14) will perform loss-of-function studies with a nanoformulated RNA therapy in a large animal (porcine) model of ischemic heart failure. The other ESR (TRAIN-HEART ESR project 15) will perform gain-of-function studies with a nanoformulated RNA therapy in a large animal (porcine) model of ischemic heart failure. These ESR positions are part of the TRAIN-HEART consortium, a Marie-Sklodowska Curie Innovative Training Network that started on the 1st of June 2019.

 

 

ABOUT UNIVERSITY OF PORTO

University of Porto (UP) is Portugal’s second largest university (almost 30,000 students and 2,200 full-time academic staff) and the largest producer of science (responsible for over 23% of the Portuguese scientific papers indexed at the ISI - Web of Science), with 14 faculties and 16 libraries distributed over 3 campuses. It provides over 600 training courses in all scientific areas. As a Research University, it hosts 49 research centres recognized by the Portuguese Science Foundation. The Faculty of Medicine of the University of Porto (FMUP) is renowned with its 8 academic departments and two R&D units, which cover different areas of biomedical research. More than 50% of the research staff are medical doctors, while the remaining professionals come from different backgrounds. The Department of Surgery and Physiology of the Faculty of Medicine participates in the TRAIN-HEART consortium. Prof. Adelino Leite Moreira, Full Professor of Physiology, Pathophysiology & Cardiothoracic Surgery, will be supervising both ESR projects at University of Porto.

 

ABOUT TRAIN-HEART

The TRAIN-HEART consortium, funded by the European Commission (2019-2023), is made up to train the next-generation of innovation-minded researchers who are able to explore and translate pathogenic insights, accelerate the development of existing RNA therapeutics, and effectively implement innovative drug delivery systems to improve safety and therapeutic efficacy for the treatment of ischemic heart failure. Academic, clinical and industry partners, covering various disciplines ranging from cardiovascular biology to clinical pharmacology and functional genomics to drug development, have teamed up in the EU:

  • Maastricht University (The Netherlands)
  • Hannover Medical School (Germany)
  • King’s College London (United Kingdom)
  • Claude Bernard Lyon University (France)
  • Technical University Munich (Germany)
  • Humanitas University (Milan, Italy)
  • University Hospital Hamburg (Germany)
  • University of Porto (Portugal)
  • Mirabilis Therapeutics BV (Maastricht, The Netherlands)
  • Miltenyi Biotec (Cologne, Germany).

TRAIN-HEART website url: http://www.train-heart.eu

 

ABOUT THE ESR PROJECTS

The PhD students will be enrolled in the FMUP’s Graduate School (i.e. Department for Research and Post-Graduate Studies) and the Doctoral Programme in Cardiovascular Sciences and guided by two accredited supervisors.

 

TRAIN-HEART ESR PROJECT 14

  • Main supervisor: Prof. Adelino Leite Moreira.
  • Co-supervisor: Dr Inês Falcão Pires.

This PhD student will use an optimised dose and route of administration to treat pigs subjected to myocardial infarction with intracardiac delivery of nanoformulated antisense oligonucleotides. The therapeutic benefit will be measured by serial MRI/invasive haemodynamic evaluations, followed by clinical chemistry, immunohistochemical data, liver and kidney sections of the porcine model to test for absence of toxicological side effects.

Secondments: This PhD student will have the opportunity to spend 3 months at Hannover Medical School (Germany) to phenotype animal models using invasive and non-invasive imaging technology. Another non-academic secondment opportunity is proposed for 2 months at Accelero Bioanalytics (Berlin, Germany) learn about the development of sandwich-based ELISAs and hybridisation techniques to facilitate the pharmacokinetics of nanomedicines. Accelero develops custom-made bioanalytical testing methods as requested for the characterisation of novel therapies. These testing methods include gene therapy assays ranging from hybridization assays to RT qPCR to assess biodistribution and intracellular delivery. Accelero also performs immunology assays to investigate immune response to microRNA and other nucleic acids therapeutics.

 

TRAIN-HEART ESR PROJECT 15

  • Main supervisor: Prof. Adelino Leite Moreira.
  • Co-supervisor: Dr André Lourenço.

This PhD student will use an optimised dose and route of administration to treat pigs subjected to myocardial infarction with intracardiac delivery of nanoformulated sense oligonucleotides (mimics). The therapeutic benefit will be measured by serial MRI/ invasive haemodynamic evaluations, followed by clinical chemistry, immunohistochemical data, liver and kidney sections of the porcine model to test for absence of toxicological side effects.

Secondments: This PhD student will have the opportunity to spend 3 months at Technical University Munich, Germany (group of Stefan Engelhardt) to learn pharmacology/toxicity principles of new oligonucleotide-based drug candidates. Another non-academic secondment opportunity is proposed for 2 months at Accelero Bioanalytics (Berlin, Germany) learn about the development of sandwich-based ELISAs and hybridisation techniques to facilitate the pharmacokinetics of nanomedicines. Accelero develops custom-made bioanalytical testing methods as requested for the characterisation of novel therapies. These testing methods include gene therapy assays ranging from hybridization assays to RT qPCR to assess biodistribution and intracellular delivery. Accelero also performs immunology assays to investigate immune response to microRNA and other nucleic acids therapeutics.

Benefits

The per annum MSCA PhD student living and mobility allowance (plus family allowance if applicable, family status is assessed at recruitment) is in line with EU-MSCA requirements. This amount will be subject to tax and employee’s National insurance deductions and will be paid in EURO.

Eligibility criteria

Applicants can be of any nationality and must be Early Stage Researchers and shall at the date of recruitment by University of Porto, be in the first four years (full-time equivalent research experience) of their research careers and have not been awarded a doctoral degree. Furthermore. the applicant must not have resided or carried out his/her main activity (work, studies, etc) in the country of his/her host organisation for more than 12 months in the 3 years immediately prior to his/her recruitment.

Selection process

HOW TO APPLY

Complete applications in English should include the TRAIN-HEART Application Form and its mandatory attachments (http://train-heart.eu/apply-for-a-train-heart-position). Please note that applications that do not meet these requirements WILL NOT BE CONSIDERED.

Please send the complete package as 1 PDF file via email to info@train-heart.eu before 7 Septsember 2019 18:00h - Europe/Brussels.

Additional comments

Selected applicants will be invited to a following face-to-face interview round. Awarding decisions will be announced shortly thereafter, and candidates are expected to be available to start their projects between September and December 2019.

Web site for additional job details

Offer Requirements

Skills/Qualifications

TRAIN-HEART ESR project 14

We expect a Master´s degree (or equivalent) in Medicine and/or Health and/or Life Sciences. Furthermore, the applicant should be able to perform team-oriented as well as independent work.

Desirable methodological skills: excellent background in cardiothoracic surgery and/or hands-on knowledge of experimental animal models.

 

TRAIN-HEART ESR project 15

We expect a Master´s degree (or equivalent) in Medicine and/or Health and/or Life Sciences. Furthermore, the applicant should be able to perform team-oriented as well as independent work.

Desirable methodological skills: excellent background in cardiothoracic surgery and/or hands-on knowledge of experimental animal models.

Specific Requirements

TRAIN-HEART ESR project 14

REQUIRED EDUCATION LEVEL

A degree (MSc, or equivalent) in Medicine (Cardiothoracic Surgery or Cardiovascular Medicine) or Health or Life Sciences (Biomedical Sciences or Molecular Life Sciences) or closely related fields. Candidates in the final stages of obtaining their degree are eligible to apply.

REQUIRED LANGUAGES

ENGLISH: Excellent, both written and spoken.

 

TRAIN-HEART ESR project 15

REQUIRED EDUCATION LEVEL

A degree (MSc, or equivalent) in Medicine (Cardiothoracic Surgery or Cardiovascular Medicine) or Health or Life Sciences (Biomedical Sciences or Molecular Life Sciences) or closely related fields. Candidates in the final stages of obtaining their degree are eligible to apply.

REQUIRED LANGUAGES

ENGLISH: Excellent, both written and spoken.

Work location(s)
2 position(s) available at
University of Porto
Portugal
Porto
4099-002
Praça de Gomes Teixeira

EURAXESS offer ID: 403791

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