17/04/2019

PhD Position in Development of a Portable Sensor based on Molecularly Imprinted Polymer for Detection of a Disease-related Protein

This job offer has expired


  • ORGANISATION/COMPANY
    Tallinn University of Technology
  • RESEARCH FIELD
    ChemistryAnalytical chemistry
    ChemistryBiochemistry
    TechnologyMaterials technology
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
  • APPLICATION DEADLINE
    12/06/2019 17:00 - Europe/Athens
  • LOCATION
    Estonia › Tallinn
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    40
  • OFFER STARTING DATE
    02/09/2019

Description
We offer a 4-year PhD position in development of a portable sensor based on molecularly imprinted polymer for detection of a disease-related protein. The overall objective of the proposed doctoral study will be to design and synthesize MIP materials for recognition of a specific disease-related protein biomarker. The resulting protein-MIPs will be interfaced with various sensor platforms in order to develop a cost-effective and portable sensor for an accurate and real-time analysis of a specific disease biomarker.

The following specific aims are foreseen:

  • The rational selection of functional monomers using computational modeling and spectroscopic analysis
  • Finding of an optimal polymerization method to produce polymer in the presence of target proteins and an efficient procedure for target molecule removal from the polymer matrix to form MIP
  • Adapting the synthesis methods to generate protein-MIP with enhanced specific surface area: integration a MIP with carbon or silicon nanoscale materials; formation of a MIP by colloidal lithography
  • Study of the analytical performance of the prepared MIP based sensors
  • Rational improvement of protein-MIPs to approach biological receptors in terms of affinity and selectivity towards the chosen target analytes

Background
Nowadays, clinical diagnostics there is an increasing demand for fast and reliable analytical methods for detection of specific disease-related biomarkers and suitable for achieving appropriate selectivity with low limit of detection while being low-cost, portable and capable of in situ real-time monitoring.
Molecularly imprinted polymers (MIPs) are tailor-made materials capable of to recognize and bind a particular target analyte with specificity and selectivity. MIPs are prepared in a course polymerization of monomers in the presence of a target analyte acting as a template, which is washed out when the polymer has been formed.

Who do we look for?

  • You have obtained a Master degree in Chemistry, Analytical chemistry, Biochemistry, Materials science
  • You have an experience in the field of polymer synthesis, biochemistry, electrochemistry, sensors, nanofabrication
  • You have good laboratory skills
  • You have ability to write up results of own research and prepare for presentation to the research team

Benefits

Doctoral students will be provided with the research position and allowance

Selection process

The top candidates for the post may be interviewed and asked to present their scientific work and experience.

Offer Requirements

  • REQUIRED EDUCATION LEVEL
    Chemistry: Master Degree or equivalent
    Other: Master Degree or equivalent
  • REQUIRED LANGUAGES
    ENGLISH: Excellent

Specific Requirements

Application Procedure

The following documents must be attached to the application (in English):

  • Motivation letter (1 – 2 pages)
  • CV with the names and contact details of 2 – 3 referees
  • Full publication list
  • Copies of relevant official degree

Work location(s)
1 position(s) available at
Tallinn University of Technology
Estonia
Tallinn
19086
Ehitajate tee 5

Open, Transparent, Merit based Recruitment procedures of Researchers (OTM-R)

Know more about it at Tallinn University of Technology

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EURAXESS offer ID: 400572

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