ORGANISATION/COMPANYTallinn University of Technology
RESEARCH FIELDChemistry › Analytical chemistryChemistry › BiochemistryTechnology › Materials technology
RESEARCHER PROFILEFirst Stage Researcher (R1)
APPLICATION DEADLINE12/06/2019 17:00 - Europe/Athens
LOCATIONEstonia › Tallinn
TYPE OF CONTRACTTemporary
HOURS PER WEEK40
OFFER STARTING DATE02/09/2019
We offer a 4-year PhD position in development of a portable sensor based on molecularly imprinted polymer for detection of a disease-related protein. The overall objective of the proposed doctoral study will be to design and synthesize MIP materials for recognition of a specific disease-related protein biomarker. The resulting protein-MIPs will be interfaced with various sensor platforms in order to develop a cost-effective and portable sensor for an accurate and real-time analysis of a specific disease biomarker.
The following specific aims are foreseen:
- The rational selection of functional monomers using computational modeling and spectroscopic analysis
- Finding of an optimal polymerization method to produce polymer in the presence of target proteins and an efficient procedure for target molecule removal from the polymer matrix to form MIP
- Adapting the synthesis methods to generate protein-MIP with enhanced specific surface area: integration a MIP with carbon or silicon nanoscale materials; formation of a MIP by colloidal lithography
- Study of the analytical performance of the prepared MIP based sensors
- Rational improvement of protein-MIPs to approach biological receptors in terms of affinity and selectivity towards the chosen target analytes
Nowadays, clinical diagnostics there is an increasing demand for fast and reliable analytical methods for detection of specific disease-related biomarkers and suitable for achieving appropriate selectivity with low limit of detection while being low-cost, portable and capable of in situ real-time monitoring.
Molecularly imprinted polymers (MIPs) are tailor-made materials capable of to recognize and bind a particular target analyte with specificity and selectivity. MIPs are prepared in a course polymerization of monomers in the presence of a target analyte acting as a template, which is washed out when the polymer has been formed.
Who do we look for?
- You have obtained a Master degree in Chemistry, Analytical chemistry, Biochemistry, Materials science
- You have an experience in the field of polymer synthesis, biochemistry, electrochemistry, sensors, nanofabrication
- You have good laboratory skills
- You have ability to write up results of own research and prepare for presentation to the research team
Doctoral students will be provided with the research position and allowance
The top candidates for the post may be interviewed and asked to present their scientific work and experience.
REQUIRED EDUCATION LEVELChemistry: Master Degree or equivalentOther: Master Degree or equivalent
REQUIRED LANGUAGESENGLISH: Excellent
The following documents must be attached to the application (in English):
- Motivation letter (1 – 2 pages)
- CV with the names and contact details of 2 – 3 referees
- Full publication list
- Copies of relevant official degree
EURAXESS offer ID: 400572
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