22/02/2019
The Human Resources Strategy for Researchers
Marie Skłodowska-Curie Actions

PhD position in: Use of PAT for monitoring and predictive control on continuous downstream processes


  • ORGANISATION/COMPANY
    Politecnico di Milano
  • RESEARCH FIELD
    Biological sciencesBiological engineering
    ChemistryBiochemistry
    EngineeringBiomaterial engineering
    EngineeringChemical engineering
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
  • APPLICATION DEADLINE
    29/03/2019 12:00 - Europe/Brussels
  • LOCATION
    Italy › Milano
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    40
  • OFFER STARTING DATE
    01/05/2019
  • EU RESEARCH FRAMEWORK PROGRAMME
    H2020 / Marie Skłodowska-Curie Actions
  • REFERENCE NUMBER
    CODOBIO ESR13
  • MARIE CURIE GRANT AGREEMENT NUMBER
    812909

CODOBIO – Continuous Downstream Processing of Biologics - is a recently granted Marie Skłodowska Curie European Training Network. CODOBIO is implemented by a European Consortium of universities, research institutions and companies in the field of bioprocess engineering. Main objectives of CODOBIO are (i) process control and modelling of continuous downstream processes, (ii) miniaturization, scale-up and –down of continuous downstream processes and (iii) process design and development of integrated continuous downstream processes.

This PhD position will be hosted in the department of Chemistry, Materials and Chemical Engineering "Giulio Natta", at Politecnico di Milano, Italy. This PhD position offers the opportunity to work in a leading university in the field of continuous processes and to experience an international framework. A prerequisite for the candidate is therefore the propensity and availability to travel. The main objectives of the project are:

  • Defining deterministic and statistical methods to monitor the process and the variability in the inputs. The use of hybrid models will be evaluated. Particular attention will be paid to capture, polishing and concentration steps. Continuous virus inactivation steps will be also part of the investigation.
  • Define online monitoring for the definition of quality in input/output streams. Focus will be put on combination of techniques (e.g. UV+Raman).
  • Define strategies for the control of the different steps in combination with continuous optimization of the process throughput and column and buffer utilization.
  • Define procedures to regress model parameter (or train statistical models) and to test models on their ability to ensure product quality.
  • Define strategy to correct predictive models by using off-line data.

Benefits

  • Be part of a highly interacting interdisciplinary project team – structured secondments to other project partners are planned
  • Start to build up your scientific network - meet and exchange regularly with 15 other PhD students working in the same project
  • Join an embedded and customized education program– gain scientific/technical skills as well as transferable skills to complement your qualification

Eligibility criteria

  • Specific Eligibility Criteria valid at time of recruitment on the H2020 Marie Skłodowska Curie programme:
    • The applicants has to be within the first four years (full-time equivalent research experience) of their research careers and have not been awarded a doctoral degree.
    • Mobility rule: The applicants may not have resided or carried out main activity (studies, work, etc.) in Italy for more than 12 months in the 3 years prior to the recruitment date.

Selection process

To apply for this position, write an e-mail to Mattia Sponchioni, mattia.sponchioni@polimi.it (cc: davide.moscatelli@polimi.it) by stating in the subject the reference number CODOBIO ESR13. Please attach to the e-mail: copy of your CV; motivation letter; certificate of your degree and proof of residence for the last three years.

Offer Requirements

  • REQUIRED EDUCATION LEVEL
    Biological sciences: Master Degree or equivalent
    Engineering: Master Degree or equivalent
    Chemistry: Master Degree or equivalent
  • REQUIRED LANGUAGES
    ENGLISH: Excellent

Skills/Qualifications

  • Excellent skills in spoken and written English
    • Master’s degree or equivalent in Chemical Engineering, Biomedical Engineering or Biological Engineering.
    • Interpersonal skills conductive to team work and group research efforts
    • Travel abroad for training purposes is part of the training programme

    Map Information

    Job Work Location Personal Assistance locations
    Work location(s)
    1 position(s) available at
    Politecnico di Milano
    Italy
    Milano
    20131
    Piazza Leonardo da Vinci 32

    EURAXESS offer ID: 382288