12/02/2019
Marie Skłodowska-Curie Actions

Coronaviruses: cross–tissue and cross–species infectivity

This job offer has expired


  • ORGANISATION/COMPANY
    Jagiellonian University
  • RESEARCH FIELD
    Biological sciencesOther
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
  • APPLICATION DEADLINE
    01/04/2019 23:00 - Europe/Brussels
  • LOCATION
    Poland › Krakow
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    40
  • OFFER STARTING DATE
    02/09/2019
  • EU RESEARCH FRAMEWORK PROGRAMME
    H2020 / Marie Skłodowska-Curie Actions
  • MARIE CURIE GRANT AGREEMENT NUMBER
    812673

About Organovir

Organovir is an Innovative Training Network (ITN) that focuses on the use of organoid technology for viral pathogenesis studies and anti-viral testing. For this ITN we will provide 15 Early Stage Researchers (ESRs) with the opportunity to be trained within a consortium of public and private experts that will enable them to lead innovation in the field of organoids for virus research. The starting date of the research projects is 1st of September 2019.

 

As an ESR with Organovir, you will be able to familiarize yourself not only with the scientific and technical aspects of innovative 3D culture systems for virus research, but also with the financial, commercial, ethical, communicative, policy and dissemination aspects enabling optimal valorisation of organoids. At the end of this project, you will hold a unique position within the European labour market.

 

Within Organovir research will be done in the areas of virology, organoid technology, science ethics, communications and business. Organovir is therefore looking for talented and motivated ESRs with a Master degree in various disciplines depending on the research project you want to apply for (see vacancies for requirements).

 

We offer challenging research projects that will lead to a dissertation (PhD thesis) at high profile universities, research institutions and companies located in the Netherlands, Belgium, Switzerland, France, Poland, Denmark, the United Kingdom and the United States of America. You can find more information about Organovir and all the research projects on the Organovir website.

 

The application deadline for all research projects is the 1st of April, 2019.

 

 

Project title: Coronaviruses: cross–tissue and cross–species infectivity (ESR 7)

Host institution: Jagiellonian University, Poland. The research will be carried out in a young and dynamic team lead by Krzysztof Pyrc. The Jagiellonian University is located in the historical, yet vibrant city of Krakow.

 

About the host institution

The team of prof. Krzysztof Pyrc works at two faculties: Faculty of Biochemistry, Biophysics and Biotechnology (FBBB) and Malopolska Center of Biotechnology (MCB). The first unit is teaching/training-oriented, the second unit (with high-containment laboratories) functions as a R&D unit, with state of the art facilities. FBBB JU is the best biology/biotechnology faculty in Poland, according to the 2017 governmental scientific unit assessment. The MCB is the first University – based research institute and at the same time the excellence center. It gathers excellent internationally renowned scientists and laboratories (including Max Planck laboratory and CNRS), and periodic evaluation of researcher coordinated by the independent, international advisory board ensures high scientific quality.

 

Project description

This project focuses on the potential of coronaviruses to cross tissue and species borders using 3D ex vivo cultures. During this project, you will be focussing on the following research objectives:

  • To create a model for coronaviral infection of the human gut, human and animal HAE cultures.
  • To test infection of different tissues with human and animal coronaviruses.
  • To understand determinants of the infection: receptor usage, cellular proteases, internalization pathways, other factors restricting viral replication.

 

With this project, we aim to achieve the following results:

  • Develop human and animal 3D gut and airway models to complement the existing ones.
  • On tissue level: identify factors limiting cross-tissue and cross-species transfer.
  • On single cell level: to understand what the virus needs to start the infection and to produce viable progeny.

 

This project also includes three secondments, which are as follows:

  • A three-month secondment with the Universiteit van Amsterdam (location: Amsterdam, the Netherlands) focused on bringing gut organoids to JU.
  • A six-month secondment with Universiteit Utrecht (location: Utrecht, the Netherlands) focused on viral infections of different tissues / species.
  • A one-month secondment with Stemcell Technologies UK LTD (location: Cambridge, United Kingdom) focused on commercial aspects of the research.

 

You will be guided during your research project by Krzysztof Pyrc (Virogenetics Laboratory of Virology).

 

Requirements

Organovir is looking for research candidates who are highly motivated and enthusiastic with a flexible, pro-active team spirit and a recent Master degree in the field of biochemistry, cell biology, molecular biology, virology, tissue engineering, life sciences and related. Interest and experience in virus culture and organoid technology is an advantage. The candidate is required to be proficient in the English language and should be in the first four years (full-time equivalent) of their research careers. In addition, the applicant should not, at the time that he/she is selected by the host institution, have resided or carried out their work and/or studies in the country of the host institution for more than 12 months in the 3 years immediately prior to their recruitment. Find here an overview of the requirements.

 

What we offer

We offer a 4-year research position for 40 hours per week within a motivated and innovative consortium. The starting date of the research project is the 1st of September 2019.

 

To apply for this research position, go to our website and fill in the application form. Only complete applications will be considered.

Eligibility criteria

You are eligible to apply for an ESR position if you meet the following conditions:

 

Early-stage researchers (ESR) are those who are, at the time of recruitment by the host institution, in the first four years (full-time equivalent) of their research careers. This is measured from the date when they obtained the degree which formally entitles them to embark on a doctorate, either in the country in which the degree was obtained or in the country in which the research training is provided, irrespective of whether or not a doctorate was envisaged.

 

Conditions of international mobility of researchers: Researchers are required to undertake trans-national mobility (i.e. move from one country to another) when taking up the appointment. At the time of selection by the host institution, researchers must not have resided or carried out their main activity (work, studies, etc.) in the country of their host organisation for more than 12 months in the 3 years immediately prior to their recruitment. Short stays, such as holidays, are not taken into account.

Offer Requirements

  • REQUIRED LANGUAGES
    ENGLISH: Excellent

Specific Requirements

Organovir is looking for research candidates who are highly motivated and enthusiastic with a flexible, pro-active team spirit and a recent Master degree in the field of biochemistry, cell biology, molecular biology, virology, tissue engineering, life sciences and related. Interest and experience in virus culture and organoid technology is an advantage. The candidate is required to be proficient in the English language and should be in the first four years (full-time equivalent) of their research careers. In addition, the applicant should not, at the time that he/she is selected by the host institution, have resided or carried out their work and/or studies in the country of the host institution for more than 12 months in the 3 years immediately prior to their recruitment. Find here an overview of the requirements.

Work location(s)
2 position(s) available at
Jagiellonian University
Poland
Krakow
31-007
Gołębia 24

Open, Transparent, Merit based Recruitment procedures of Researchers (OTM-R)

Know more about it at Organovir

Know more about OTM-R

EURAXESS offer ID: 379244

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