18/01/2019
Marie Skłodowska-Curie Actions
Science 4 Refugees

HEalth data LInkage for ClinicAL benefit - Extracellular Vesicles (EV) as markers of active disease in AAV

This job offer has expired


  • ORGANISATION/COMPANY
    Medical University of Vienna
  • RESEARCH FIELD
    Medical sciencesMedicine
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
  • APPLICATION DEADLINE
    15/03/2019 23:00 - Europe/Brussels
  • LOCATION
    Austria › Vienna
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    40
  • OFFER STARTING DATE
    01/04/2019
  • EU RESEARCH FRAMEWORK PROGRAMME
    H2020 / Marie Skłodowska-Curie Actions
  • MARIE CURIE GRANT AGREEMENT NUMBER
    813545

The post is for an early stage researcher (ESR) who will undertake a three year PhD studentship as part of the H2020-MSCA-ITN-2018 HELICAL (Co-ordinator: Professor Mark Little, Trinity College Dublin, TCD). HELICAL is an EU funded Marie Curie Innovative Training Network (ITN) with 17 Academic Partners and nine Non-Academic Partners. 

The appointee will be trained in advanced image cytometry, statistical genetics and systems biology applied to giant cell arteritis pathogenesis. General training will include enhancement of their awareness of FAIR and GDPR data principles. The HELICAL ITN is highly integrated and so the appointee will also have the opportunity to acquire additional skills through regular meetings, workshops and seminars, and through secondments to other partners in the HELICAL network.

Project title ESR No. 11 - Extracelluar Vesicles (EV) as markers of active disease in AAV

The present post is based in the Department of Pathology at the Medical University of Vienna and will be supervised by Professor RENATE KAIN.

Rationale: The project is based on the fact that a lack of means to reliably identify the cells EVs originate from has hampered the use of EVs as markers of disease activity.

Objectives: The appointee will optimise methods to isolate EVs and analyse their cellular and organ origin by assessing differentially expressed surface proteins. In collaboration with KTH, the targeted approach will exploit the resources and expertise from the Human Protein Atlas and use the unique proteome-wide collection of polyclonal antibodies in well-established antibody array and magnetic bead technology, complemented by classical protein biochemistry, proteomic and immunological methods. Once the analysis of surface expressed protein repertoire allows reliable linkage of individual EV patterns to the tissue of origin, the ESR will analyse complex EV mixtures in plasma samples from healthy subjects and from two well characterised clinical cohorts of patients with vasculitis at various stages of disease, and stratified by gender (INTRICATE discovery cohort [MUW] and RKD [TCD] validation cohort) to evaluate whether these methods can be used to identify individual EV subsets in healthy subjects and patients with AAV (ANCA-associated vasculitis).

Expected Results: Sera from patients with quiescent and active AAV will be evaluated as to whether they can be used as biomarkers of active disease, using machine learning that incorporates clinical data to develop diagnostic algorithms.

 

 

Benefits

Remuneration according to standard EU rates for ESRs:

The per annum Marie Skłodowska-Curie Early Stage Researcher living and mobility allowance (plus family allowance if applicable, family status is assessed at the time of recruitment and will not evolve during the action lifetime) is in line with Marie Skłodowska-Curie Innovative Training Network requirements. This amount will be subject to tax and employee’s National Insurance deductions, and will be paid in EUR.

Eligibility criteria

The following eligibility criteria apply:

Early-stage researchers (ESRs) must, at the date of recruitment by the beneficiary, be IN THE FIRST FOUR years* (full-time equivalent research experience) of their research careers and have not been awarded a doctoral degree.

* measured from date when researchers obtained the degree which would formally entitle them to embark on a doctorate.

Researchers who have NOT resided or carried out their main activity (work, studies, etc.) in the country of the recruiting beneficiary for MORE than 12 months in the 3 years IMMEDIATELY BEFORE the recruitment date. Compulsory national service, short stays such as holidays, and time spent as part of a procedure for obtaining refugee status under the Geneva Convention are not taken into account.

International European interest organisations or international organisations cannot recruit researchers who have spent more than 12 months in the 3 years immediately before the recruitment date at the same appointing organisation.

 

Selection process

Applicants submit their applications by 18 April 2019.

Host institutions perform a first eligibility check and shortlist candidates.

A Board Meeting will be held .

Applicants will be asked to submit university diplomas, certificates, transcripts, proof of skills and 2 references after shortlisting/prior to an interview.

Interviews with applicants will be held from the week commencing 11 Mar 2019.

Interviews will take place via Zoom webex with 2-3 Panel members + local Principal Investigator.

Successful candidates will be informed by 25 March 2019 at the earliest.

Additional comments

Please email the following documents to the indicated contact:

a. Statement of motivation (max. 500 words)

b. 1-page CV (applications with CVs exceeding 1 page will be rejected) including up to 5 most important publications

c. Internal Application Form available under "Basic Information". In this form you can identify also up to two alternative projects within the HELICAL Consortium. Please visit the HELICAL website for further job details (Research Projects).

 

The HELICAL ITN includes 17 Academic Partners (Trinity Collecge Dublin (IRL); MedUni Vienna (A); University of Glasgow, Farr Institute, University of Leeds, Leeds Institute for Data Analytics (UK); Universite Paris Diderot (F); Kungliga Tekniska Hoegskolan, Uppsala Universitet (S); Consorci Institut d´Investigations Biomediques, Consejo Superior De Investigaciones Cientificas, Instituto de Salud Global de Barcelona, Instituto de Investigaciones Marques de Valdecilla, Universitat de Barcelona, Universitat Autónoma de Barcelona (E); Charles University (CZ); Ghent University (B)) and nine Non-Academic Partners (Tissuegnostics (A); IBM Zurich (CH); patientMpower (IRL); Anaxomics Biotech (E); Firalis (F); European Institute for Innovation in Health Data (B); RITA-Newcastle University, Laser Analytica, Eagle Genomics (UK)).

It will provide a trans-sectoral and interdisciplinary training programme with state of the art training in analysis of large datasets from individuals with chronic inflammatory disease, using autoimmune vasculitis as a paradigm. HELICAL key complementary areas: application of informatics to such datasets to gain new biological insights, translation of biological into practical clinical outputs, and identification of novel ethical constraints and development of strategies to manage them.

HELICAL is funded under the H2020-MSCA-ITN-2018 designed to promote movement of researchers in Europe and so is open to citizens from any country in the world other than Austria provided they have not worked there for more than 12 months in the previous three years. HELICAL pursues a policy of equal opportunities on matters of gender and disability and will seek to recruit an equal proportion of male and female applicants and will provide employment opportunities for candidates with disabilities. Where applications of equal quality are received, preference will be given to female candidates as part of a strategy designed to recruit equal numbers of men and women to the HELICAL posts. Employment procedures and contracts will conform to the European Charter for Researchers / Code of Conduct for the Recruitment of Researchers.

 

Web site for additional job details

Required Research Experiences

  • RESEARCH FIELD
    Medical sciencesMedicine
  • YEARS OF RESEARCH EXPERIENCE
    1 - 4

Offer Requirements

  • REQUIRED EDUCATION LEVEL
    Medical sciences: Master Degree or equivalent
  • REQUIRED LANGUAGES
    ENGLISH: Excellent
    GERMAN: Good

Skills/Qualifications

  • Experience of undertaking academic research; experience in statistics, bioinformatics or computational biology would be an advantage
  • Good IT skills
  • Excellent analytical and problem-solving skills with good attention to detail
  • Good interpersonal and communication skills, both written and verbal, and the ability to communicate effectively with a wide range of stakeholders
  • Good time management and planning skills, with the ability to meet tight deadlines and manage competing demands effectively
  • A proven ability to work well both independently and as part of a team
  • A strong commitment to your own continuous professional development
  • Ability to perform practical experimental measurements
  • Ability to interpret results and perform analysis on experimental data
  • Ability to write scientific reports and papers using clear and concise English
  • Ability to communicate research results through scientific presentations
  • Ability to develop creative approaches to problem solving
  • Ability to analyse and solve problems with an appreciation of longer-term implications
  • Ability to direct own day-to-day work

Specific Requirements

As the project may involve patient contact and recruitment, medical training and some command of the German language are beneficial, but not mandatory.

Analysis of data sets from proteomics and transcriptomics

Cell culture and generation of extracellular vesicles

 

 

Work location(s)
1 position(s) available at
Medical University of Vienna
Austria
Vienna
1090
Waehringer Guertel 18-20

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EURAXESS offer ID: 371555