14/01/2019
Marie Skłodowska-Curie Actions

15 PhD positions in Marie Sklodowska Curie ITN "pH and Ion Transport in Pancreatic Cancer" (pHioniC)

This job offer has expired


  • ORGANISATION/COMPANY
    Westfälische Wilhelms-Universität Münster
  • RESEARCH FIELD
    Biological sciencesOther
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
  • APPLICATION DEADLINE
    20/02/2019 23:00 - Europe/Brussels
  • LOCATION
    Multiple locations, see work locations below.
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    ~40
  • OFFER STARTING DATE
    01/09/2019
  • EU RESEARCH FRAMEWORK PROGRAMME
    H2020 / Marie Skłodowska-Curie Actions
  • MARIE CURIE GRANT AGREEMENT NUMBER
    813834

15 PhD Positions

are available within the

Marie Skłodowska Curie Innovative Training Network on

pH and Ion Transport in Pancreatic Cancer – pHioniC

 

pHioniC (www.medizin.uni-muenster.de/phionic/home/) is a Marie Skłodowska Curie Innovative Training Network funded by the European Commission. We are an established team of 10 academic and 2 industrial partner organizations from 7 European countries specialized in the field of ion transport in oncology. Our current research activities are centered on pancreatic cancer which is still one of the deadliest cancers. Our team pursues a highly innovative approach by focusing on the role of the unique pancreatic microenvironment for disease progression (see Bioassays 39, 6, 1600253, 2017 for a detailed elaboration of the underlying hypothesis). We will provide a structured 3-years cutting-edge PhD training programme in and beyond the fields of ion transport and oncology, including among others complex in vitro / in vivo model systems and various (ionic) imaging techniques, electrophysiology as well as bioinformatics and genomics. The anticipated starting date will be 01 September, 2019. pHioniC builds upon the success and experience of our previous ITN IonTraC (www.medizin.uni-muenster.de/iontrac/home/).

We are looking for highly motivated and talented PhD students holding a Master degree in medical science, biology, biochemistry, biotechnology, physics, chemistry, bioinformatics or related fields, with relevant preparative training. Excellent command of spoken and written English, communication skills as well as team spirit are essential. We are offering a competitive, interdisciplinary environment with a track record of intense mutual collaboration. In addition to the individual training-through-research our programme includes further elements such as workshops, summer schools, internships and secondments to the partners’ laboratories.

The following eligibility rules apply for participation in a Marie Skłodowska Curie Innovative Training Network: Applicants must be in the first 4 years after obtaining their Master´s degree and must  not  have  resided  or  carried  out  their  main  activity  (work, studies,  etc.) in the host country for more than 12 months in the 3 years immediately before the recruitment date. In addition, local regulations of the host countries may apply.

The salary is based on standard living, mobility and family allowances which are adapted to the respective country of recruitment.

The following positions are available:

1 PhD at the University of Münster, Germany

Principal Investigator (PI) and coordinator Albrecht Schwab (aschwab@uni-muenster.de)

Modulation of pressure sensing of pancreatic stellate cells by pancreatic pH.

 

1 PhD at the University of Oxford, United Kingdom

PI Pawel Swietach (pawel.swietach@dpag.ox.ac.uk),

Modelling and understanding spatio-temporal pH dynamics in PDAC in silico using in vivo and in vitro data.

 

3 PhDs at the University of Copenhagen, Denmark

1. PI Ivana Novak (inovak@bio.ku.dk)

Role of pH and purinergic signaling in normal pancreas and PDAC.

2. PI Stine F. Pedersen (sfpedersen@bio.ku.dk)

Interactions between microenvironmental acidity and PDAC driver mutations studied in 3D organotypic culture.

3. PI Albin Sandelin (albin@binf.ku.dk)

Relation and causality between pH homeostasis and driver mutation generation in PDAC development.

 

1 PhD at the University of Bari, Italy

PI Stephan J Reshkin (stephanjoel.reshkin@uniba.it)

Role of ECM composition and stromal cells in determining tumour and cancer stem cell pH/O2 handling and therapeutic response.

 

1 PhD at the University of Florence, Italy

PI Annarosa Arcangeli (annarosa.arcangeli@unifi.it)

Targeting ion channel and adhesion receptor interaction during PDAC progression by pH-sensitive engineered antibodies.

 

1 PhD at the University of Lille, France

PI Natalia Prevarskaya (Natacha.Prevarskaya@univ-lille1.fr)

Role of Ca2+ permeable channels in PDAC and PSCs.

 

1 PhD at the University of Picardie Jules Verne in Amiens, France

PI Halima Ouadid-Ahidouch (halima.ahidouch-ouadid@u-picardie.fr)

Expression profiling of pH-regulatory and -sensitive transportome: epigenetic analysis and correlation with clinical parameters.

 

2 PhDs at the Max-Planck-Institute for Experimental Medicine

1. PI Luis Pardo (pardo@em.mpg.de)

Simultaneous targeting of tumour cells and stroma by pH-sensitive engineered biologicals.

2. PI Frauke Alves (falves@gwdg.de)

Assessment of physico-chemical parameters of PDAC by non-invasive imaging during tumour progression and in therapeutic response to targeting pH-dependent processes.

 

1 PhD at the University of Kiel, Germany

PI Anna Trauzold (atrauzold@email.uni-kiel.de)

Acquired nuclear functions of TRAIL-receptors as a consequence and motor of pH gradient reversal in PDAC.

 

1 PhD at the University of Debrecen, Hungary

PI György Panyi (panyi@med.unideb.hu)

Ion channels of immune cells and their regulation by the micro- environment in PDAC and its interface with normal tissue.

 

1 PhD at Percuros B.V., Leiden, NL

PI Alan Chan (B.Chan@lumc.nl)

Molecular imaging of the microenvironment-transportome interplay in PDAC.

 

1 PhD at Heidelberg-Pharma Research GmbH, Germany

PI Andreas Pahl (A.Pahl@hdpharma.com)

Generation of PDAC specific ADCs and preclinical profiling.

 

Further details can be obtained from the respective PIs or the coordinator (aschwab@uni-muenster.de).

Please submit your application to the pHioniC coordinator Albrecht Schwab at the following address  phionic@uni-muenster.de until 20 February, 2019. Your applications should include the following:

  • motivation letter
  • CV
  • copies of the relevant certificates
  • brief summaries of your Bachelor and Master theses (15 lines each)
  • two to three references
  • prioritised list of the three preferred pHioniC laboratories

We are committed to an open and fair recruitment procedure according to "The Code of Conduct for the Recruitment of European Researchers".

Benefits

We are offering a competitive, interdisciplinary environment with a track record of intense mutual collaboration. In addition to the individual training-through-research our programme includes further elements such as workshops, summer schools, internships and secondments to the partners’ laboratories.

Eligibility criteria

The following eligibility rules apply for participation in a Marie Skłodowska Curie Innovative Training Network: Applicants must be in the first 4 years after obtaining their Master´s degree and must not have resided or carried out their main activity (work, studies, etc.) in the host country for more than 12 months in the 3 years immediately before the recruitment date. In addition, local regulations of the host countries may apply.

Additional comments

Some universities also require local application! Please check whether this is necessary for your favorite laboratories.

Applicants interested in the Oxford-based ESR are also required to submit their application to Oxford directly, which can be found at: https://www.dpag.ox.ac.uk/work-with-us/current-vacancies.

Web site for additional job details

Offer Requirements

Skills/Qualifications

We are looking for highly motivated and talented PhD students holding a Master degree in medical science, biology, biochemistry, biotechnology, physics, chemistry, bioinformatics or related fields, with relevant preparative training. Excellent command of spoken and written English, communication skills as well as team spirit are essential.

Work location(s)
1 position(s) available at
University of Münster
Germany
Münster
1 position(s) available at
University of Oxford
United Kingdom
Oxford
3 position(s) available at
University of Copenhagen
Denmark
Copenhagen
1 position(s) available at
University of Bari
Italy
Bari
1 position(s) available at
University of Florence
Italy
Florence
1 position(s) available at
University of Lille
France
Lille
1 position(s) available at
University of Picardie Jules Verne
France
Amiens
2 position(s) available at
Max-Planck-Institute for Experimental Medicine
Germany
Göttingen
1 position(s) available at
University of Kiel
Germany
Kiel
1 position(s) available at
University of Debrecen
Hungary
Debrecen
1 position(s) available at
Percuros B.V.
Netherlands
Leiden
1 position(s) available at
Heidelberg-Pharma Research GmbH
Germany
Ladenburg

EURAXESS offer ID: 370182

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