20/12/2018
Marie Skłodowska-Curie Actions

PEP-NET Marie-Curie ITN: 15 Early Stage Researcher Fellowships (ESR) - 3 year PhD positions


  • ORGANISATION/COMPANY
    Institutions across Europe in the PEP-NET ITN network
  • RESEARCH FIELD
    Biological sciencesBiological engineering
    Biological sciencesBiology
    Biological sciencesOther
    Computer scienceProgramming
    MathematicsProbability theory
    MathematicsStatistics
    PhysicsBiophysics
    PhysicsStatistical physics
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
  • APPLICATION DEADLINE
    31/03/2019 23:00 - Europe/Brussels
  • LOCATION
    Germany › Berlin
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    35-40
  • OFFER STARTING DATE
    01/06/2019
  • EU RESEARCH FRAMEWORK PROGRAMME
    H2020 / Marie Skłodowska-Curie Actions
  • MARIE CURIE GRANT AGREEMENT NUMBER
    813282

Applications are invited for 15 Early Stage Researcher (ESR) 3-year fixed-term positions to be funded by the Marie-Sklodowska-Curie Innovative Training Network (ITN) “PEP-NET – Predictive Epigenetics: Fusing Theory and Experiment” within the Horizon 2020 Programme of the European Commission (www.ringroselab.com)

The PEP-NET ITN goals are:

  • To break interdisciplinary barriers between theorists and experimentalists
  • To advance our understanding of fundamental epigenetic mechanisms in health and disease
  • To train our PhD students in theoretical and experimental research skills
  • To train our PhD students in transferable skills and provide experience of both academic and industrial environments

Epigenetic mechanisms of gene regulation are profoundly implicated in human health and disease. However, we are still far from a complete mechanistic understanding of many epigenetic processes. Research in epigenetics has typically been based on experiments and not on theory. This has delivered large amounts of information, but information alone is not sufficient. Further progress urgently needs a paradigm shift in the way in which we study epigenetics: epigenetics needs mathematics. Modeling epigenetic processes not only holds the key to a deep mechanistic understanding, but also ultimately, to drug response predictions, patient-specific diagnoses and new therapies.

One of the greatest challenges to uniting biology and mathematics is the barrier between disciplines, because education in each field has traditionally been mono-disciplinary. The PEP-NET ITN will overcome these barriers by uniting 16 outstanding European academic laboratories and companies who have pioneered the successful combination of theoretical and experimental epigenetics. PEP-NET will train a new cohort of 15 European PhD students to combine quantitative experiments with predictive theoretical models, and to apply this knowledge to basic and applied questions of epigenetic function.

The consortium of 11 beneficiaries (including 9 academic and 2 non-academic groups from the UK, France, Germany, Belgium, Denmark, Italy and Switzerland) will deliver multidisciplinary training in experimental and theoretical disciplines to 15 Early Stage Researchers (ESRs). Integral to the program are the international and intersectorial secondments through the network of partner organisations (from public, private and third sector, in the above countries and in Australia and USA in addition).

In addition to PhD research, training of the PEP-NET ESRs will comprise an integrated curriculum of courses in theoretical and experimental epigenetics, including mathematical modeling, computational biology, cellular imaging and molecular biology. Additional training is given in transferable skills, including paper and grant writing, presentation skills, entrepreneurship, logical and lateral thinking and many more. Each ESR will be seconded to at least one academic and one private sector partner of the project, building bridges between academic and industrial communities and breaking the barriers between experimental and theoretical research.

 

Summary of titles and host institutions for the 15 ESR positions:

NB: Some projects have different deadlines. For details of individual projects, more information and to access the application form, see “application_info.pdf” . Click on "where to apply" to download the pdf.

  • ESR 1 (Humboldt University Berlin, Germany) Visualising and modelling Polycomb/Trithorax (PcG/TrxG) regulation in real time. Main supervisor: Leonie Ringrose
  • ESR 2 (Max Planck Institute for Molecular Genetics, Berlin, Germany) Model-driven quantitative dissection of a bistable epigenetic switch in X-chromosome inactivation. Main supervisor: Edda Schulz 
  • ESR 3 (John Innes Centre, Norwich, UK) Combining analogue and digital modes of gene regulation. Main supervisor: Martin Howard
  • ESR 4 (University of Copenhagen, Denmark)  Modeling cellular memory governed by the Polycomb and Trithorax group (PcG/TrxG) proteins. Main supervisor: Kim Sneppen
  • ESR 5 (Friedrich Miescher Institute, Basel, Switzerland) Three-dimensional chromatin organisation and transcriptional regulation in single cells. Main supervisor: Luca Giorgetti
  • ESR 6 (Humboldt University Berlin, Germany) DNA sequence determinants of Polycomb targeting in flies and vertebrates. Main supervisor: Leonie Ringrose
  • ESR 7 (Humboldt University Berlin, Germany) Polycomb Targeting in the context of 3D chromatin organisation. Main supervisor: Marc Rehmsmeier
  • ESR 8 (IGBMC, Strasbourg, France) Modelling transcription factor mitotic bookmarking in a dynamic chromatin structure. Main supervisor: Nacho Molina
  • ESR 9 (San Raffaele Hospital, Milan, Italy) Transcription factor search mechanism, chromatin mobility and organisation upon DNA damage. Main supervisor: Davide Mazza
  • ESR 10 (Max Delbrück Centre for Molecular Medicine, Berlin, Germany) Investigating long-range chromatin contacts during early cell fate decisions in mouse embryos. Main supervisor: Ana Pombo
  • ESR 11 (University of Oxford, UK) Relating the 3D organisation of chromatin to antisense transcription. Main supervisor: Jane Mellor
  • ESR 12 (University of Naples Federico II, Italy) Understanding chromatin 3D organisation and its underlying physical mechanisms. Main supervisor: Mario Nicodemi
  • ESR 13 (Diagenode, Liege, Belgium) Developing technologies for analysis of long non-coding RNAs and investigation of their role in long-range chromatin contacts. Main supervisor: Céline Sabatel
  • ESR 14 (Diagenode, Liege, Belgium) Computational methods for chromatin conformation investigation. Main supervisor: Céline Sabatel
  • ESR 15 (University of Oxford, UK) Modelling parameters for resetting higher order chromatin structures. Main supervisor: Jane Mellor

 

 

Benefits

The selected candidates will receive a 36-month, full-time employment contract as per Marie Skłodowska-Curie Actions (MSCA) regulations for early stage researchers. The monthly salary will be confirmed upon offer, paid in the currency of the host country, and with a correction factor applied to the host country (additional information).

Marie Curie ITNs provide a highly competitive salary to the ESR, including a generous monthly living and mobility allowance and (if eligible) a monthly family allowance.

 

Eligibility criteria

  • The positions are open to all nationalities.
  • At the time of hiring (i.e. at the start of the contract), applicants may not have lived or carried out their main activity (work, studies) in the country in which they are hired, for more than 12 months in total in the 3 years immediately before the date on which they start their contract.
  • Early-Stage Researchers (ESRs) must, at the date of starting their contract, be within the first four years (full-time equivalent research experience) of their research careers and have not been awarded a doctoral degree.

 

Selection process

Please download the application form “application_info.pdf”. Click on "where to apply" to download the pdf.

Please send the following as a single pdf to pepnet.bio@hu-berlin.de

  • Application form
  • Transcripts and certifications from University: Bachelor and master degrees, including class ranking if possible
  • Certificate of English qualification if appropriate
  • Curriculum vitae of at most 3 pages. Europass C.V. format preferred (https://europass.cedefop.europa.eu/documents/curriculum-vitae)

Candidates selected for interview will be informed by 31.05.2018 at the latest. (Note the deadline and interview date may vary for each position, details are given in “application_info.pdf”

Additional comments

To apply, please follow the instructions in the document “application_info.pdf”. Click on "where to apply" to download the pdf.

Web site for additional job details

Required Research Experiences

  • RESEARCH FIELD
    Biological sciences
  • YEARS OF RESEARCH EXPERIENCE
    1 - 4
  • RESEARCH FIELD
    Computer science
  • YEARS OF RESEARCH EXPERIENCE
    1 - 4
  • RESEARCH FIELD
    Mathematics
  • YEARS OF RESEARCH EXPERIENCE
    1 - 4
  • RESEARCH FIELD
    Physics
  • YEARS OF RESEARCH EXPERIENCE
    1 - 4

Offer Requirements

  • REQUIRED EDUCATION LEVEL
    Biological sciences: Master Degree or equivalent
    Mathematics: Master Degree or equivalent
    Computer science: Master Degree or equivalent
    Physics: Master Degree or equivalent
  • REQUIRED LANGUAGES
    ENGLISH: Excellent

Skills/Qualifications

 

Masters degree or equivalent in any of the listed research fields. Please refer to the application form and additional information for project – specific requirements “application_info_pdf”. Click on "where to apply" to download the pdf.

Specific Requirements

Master's degree or equivalent completed at the time of appointment.

 

Map Information

Job Work Location Personal Assistance locations
Work location(s)
15 position(s) available at
Locations across Europe
Germany
Berlin

EURAXESS offer ID: 365766