RESEARCH FIELDBiological sciences › Biological engineeringBiological sciences › BiologyChemistry › BiochemistryPhysics › Biophysics
RESEARCHER PROFILEFirst Stage Researcher (R1)
APPLICATION DEADLINE07/01/2019 23:00 - Europe/Brussels
LOCATIONGermany › Freiburg
TYPE OF CONTRACTTemporary
HOURS PER WEEK39.5
OFFER STARTING DATE01/05/2019
EU RESEARCH FRAMEWORK PROGRAMMEH2020 / Marie Skłodowska-Curie Actions
REFERENCE NUMBERsynBIOcarb - ESR4
MARIE CURIE GRANT AGREEMENT NUMBER814029
Are you keen to progress research in glycoscience at the interface between biology, chemistry, physics and medicine, in the first four years of your research career? Do you want to further your career and attain a PhD in one of Germany´s leading research intensive universities?
synBIOcarb is a Marie Skłodowska-Curie Innovative Training Network. It brings together 14 leading European partners in a transnational network, implementing a multidisciplinary and intersectorial research and training programme between the academic and the industrial partners in the fields of synthetic glycobiology.
Together, we will provide 15 early stage researchers (ESRs) with advanced scientific training in chemical synthesis, protein engineering, biophysics, cell biology and analytical device technologies that underpin the development and exploitation of glycoscience for diagnostics and targeted drug delivery. Each ESR will contribute to one, or more, of four thematic work packages that have been designed to progress the state of the art in Synthetic Glycobiology.
As an Early Stage Researcher in Freiburg, you will elucidate the mechanism(s) of lectin-triggered membrane fusion and killing of cancer cells by fusion of liposomes with target cells.
All cells are covered with a coating of complex carbohydrates (the glycocalyx) and many viruses, bacteria and protein toxins produced by bacteria exploit this sugar coating as a means of binding to and entering their target cells. The glycocalyx on many living cells extends >100 nm from the cell membrane, and its outer portion is dominated by proteoglycans and mucins which have extended and highly glycosylated structures. Interactions of proteins with these glycosylated structures is important for cellular interactions and also may influence the ability of bacterial toxins to reach their primary receptors on the cell membrane.
The aim of this project is to incorporate glycoconjugates and lectins into the membrane of artificial cells (protocells) and employ them for diverse membrane fusion studies, i.e. for fusion of two protocells, but also of a protocell with a cancer cell. Through this interdisciplinary project you will develop skills in cell biology, immunology, membrane biology, glycobiology, biochemistry, and advanced microscopy techniques. Appropriate training will be provided in all areas that are new to the researcher.
The successful candidate will participate in the network’s training activities and work placements at the laboratories of the synBIOcarb academic and industrial teams. Regular meetings and workshops within the EU-funded synBIOcarb Innovative Training Network will supplement the training and support provided at the University of Freiburg. Practical scientific training will be complemented by a coordinated programme of industry-relevant transferable skills that will prepare the ESRs for future careers in the medical technologies sector.
To meet the requirements of the Marie Skłodowska-Curie Innovative Training Network, you will be an early stage researcher within the first four years of your research career, have not yet been awarded a doctoral degree (PhD), and have not lived or carried out your main activity (work/study) in Germany for more than 12 months during the past three years.
You are required to apply to this post by email to email@example.com indicating reference "synBIOcarb ESR4".
Your application should include a cover letter outlining your motivation to join this project, a CV including the names and contact details of at least two references, and transcripts of your university record.
- Have a Diploma and/or a Master Degree in Biology, Biophysics and Biochemistry.
- Experience in fluorescence microscopy and synthetic membrane systems are highly appreciated, but is not mandatory.
- Have less than 4 years research experience at the signature of the contract (measured from the time the Master’s degree has been obtained).
- Not have a PhD already.
- Not have resided or carried out main activity in Germany for more than 12 months in the last 3 years immediately prior to the reference recruitment date.
- Excellent knowledge of the English language (spoken and written / proficiency level)
EURAXESS offer ID: 362372
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