RESEARCH FIELDBiological sciences › OtherChemistry › Other
RESEARCHER PROFILEFirst Stage Researcher (R1)
APPLICATION DEADLINE28/02/2019 00:00 - Europe/Brussels
LOCATIONNetherlands › Groningen
Czech Republic › Praha
TYPE OF CONTRACTTemporary
HOURS PER WEEK40
OFFER STARTING DATE01/04/2019
EU RESEARCH FRAMEWORK PROGRAMMEH2020 / Marie Skłodowska-Curie Actions
REFERENCE NUMBERI-Direct 813871
MARIE CURIE GRANT AGREEMENT NUMBER813871
Keywords: checkpoint targeting, bispecific antibody, nanoparticles, surface modification, drug-delivery
1st Hosting institution: Location: UMCG, Groningen, Netherlands; Duration: 18 months
2nd Hosting institution: Location: InoCure, Prag, Czech Republic; Duration: 18 months
PhD-student position (3 years):
This PhD student position offers an exciting and innovative research project that aims to further develop the targeting of the PD-1/PD-L1 immune checkpoint for cancer immunotherapy. In brief, a novel bispecific antibody-based approach that selectively removes this important checkpoint at the site of the cancer will be developed. Further, the immunotherapeutic will be formulated using nanotechnology to ensure timely and tumor-localized release of bioactive drug. This approach will be tested in in-house developed model systems for tumor-selective binding and functional immunomodulatory activity.
The PhD candidate will be working as part of an international consortium on their search for an immunotherapeutic approach to cancer treatment and will start their 3 year research project at the University Medical Center Groningen (UMCG) / Netherlands, one of the leading academic centers of the Netherlands, for another 18 months. At the UMCG, new PD-1 checkpoint targeting immunotherapeutic will be developed and preclinically evaluated. After 18 months, the candidate will continue in Prague / Czech Republic at the nanobiotechnology company Inocure SRO. Inocure is a leading company in drug formulation and in in vitro modelling and the candidate will exploit this expertise for further development of PD-1 checkpoint immunotherapeutics. With this project, the candidate will acquire experience in both industrial and academic research. This research project will end with a PhD thesis defense at the University of Groningen.
This project is part of a collaborative training network of 10 closely related projects in which PhD students will benefit from networking opportunities. This includes a multidisciplinary training programme with network-wide training events that will be provided to the candidates. Herewith, the PhD project will provide the candidate a unique opportunity to obtain knowledge/expertise on important facets of both academia and industry.
SEE THE OTHER 9 PhD POSITIONS AND WORK LOCATIONS OF I-DIRECT:
10 position(s) available at various locations (2 locations for each ESR, 18 months each)
Czech Republic/The Netherlands
Required Research Experiences
RESEARCH FIELDBiological sciences › Other
YEARS OF RESEARCH EXPERIENCE1 - 4
YEARS OF RESEARCH EXPERIENCE1 - 4
REQUIRED EDUCATION LEVELBiological sciences: Master Degree or equivalentChemistry: Master Degree or equivalent
REQUIRED LANGUAGESENGLISH: Excellent
- Preparation of tumour-targeted bsAbs & immunocytokines
- Nanoparticle-based drug-delivery formulation
- Primary patient-derived cell culturing
- Development of 3D model of tumor micro-environment
- Various encapsulation and surface modification activities
- Optimization of the in vitro test conditions for a realistic simulation of the in vivo conditions
- Management, presentation and publication of research data
- Candidate is in the first four years of his/her research career and does not have a doctoral degree
- Residence duration in the Netherlands does not exceed 12 months in total within the last 3 years
- MSc in biology, biochemistry, biotechnology, engineering or related
- Collaboration skills, demonstrating agility and initiative. Ability to communicate effectively in English
EURAXESS offer ID: 360232
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