29/11/2018
Marie Skłodowska-Curie Actions

14 PhD Positions within the Marie Skłodowska-Curie ITN "Logic Lab”


  • ORGANISATION/COMPANY
    LogicLab ITN
  • RESEARCH FIELD
    Biological sciencesBiology
    Chemistry
    Engineering
    Pharmacological sciencesToxicology
    PhysicsBiophysics
    PhysicsChemical physics
    TechnologyBiotechnology
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
  • APPLICATION DEADLINE
    30/04/2019 23:00 - Europe/Brussels
  • LOCATION
    Multiple locations, see work locations below.
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    40
  • OFFER STARTING DATE
    01/04/2019
  • EU RESEARCH FRAMEWORK PROGRAMME
    H2020 / Marie Skłodowska-Curie Actions
  • REFERENCE NUMBER
    LogicLabESRs
  • MARIE CURIE GRANT AGREEMENT NUMBER
    813920

We are pleased to advertise 14 Early-Stage Researcher (PhD) positions to begin in 2019, as part of the Marie Skłodowska-Curie Innovative Training Network (MSCA-ITN) of the European CommissionMolecular logic lab-on-a-vesicle for intracellular diagnostics - Logic Lab”. The Logic Lab projects aims to develop a new concept for molecular logic sensors for application in intracellular diagnostics. Expertise in the field of classical molecular logic gates will be combined with state-of-the-art research approaches in synthetic, supramolecular and theoretical chemistry, spectroscopy as well as microfluidics and cell biology to establish new tools for biomedical research. The positions will allow all students to participate in an exciting research and training programme, enhancing their career perspectives in both the academic and non-academic sector. In addition to their individual doctoral projects, all PhD students will benefit from a dedicated training programme comprising of local and network-wide training activities related to the development of scientific knowledge and the enhancement of transferable skills. The project is coordinated by Prof. Benjamin Dietzek (Leibniz IPHT, Jena/Germany).

Beneficiaries include:

Leibniz Institute of Photonic Technology Jena, Germany (Leibniz-IPHT), Coordinator

Dublin City University, Ireland (DCU),

Friedrich Schiller University Jena, Germany (FSU),

Gdansk University of Technology, Poland (GUT),

Jagiellonian University in Krakow, Poland (JUK),

Slovak Academy of Sciences, Slovak Republic (SAS),

University Leiden, The Netherlands (UL),

Mimetas B.V. Leiden, The Netherlands (MIM),

SciClus GmbH&Co. KG, Germany (SCI)

 

Candidates will be required to meet the Marie Skłodowska-Curie Early Stage Researcher eligibility criteria:

In particular, at the time of appointment candidates must have had less than four years full-time equivalent research experience and must not have already obtained a PhD. Additionally, they must not have resided in the host country for more than 12 months in the three years immediately before the appointment. (http://ec.europa.eu/research/mariecurieactions/)

The Logic Lab consortium is committed to increase the percentage of female scientists and therefore especially encourages them to apply.

Applications must be accompanied with the following documents in PDF format:

• letter of motivation,

• curriculum vitae of at most 3 pages, including well-identified publication list

• transcripts of records from University/University College and copy of your degree

• copy of master’s thesis or any other publications (if available),

• two written recommendation letters (e.g. one by your Master thesis supervisor) and the referees contact details

 

Positions available:

ESR1: Synthesis of fluorescent sensors for NO/O2 and shear stress (DCU)

Candidates with a background in synthetic chemistry, are invited to apply for a PhD position in Supramolecular Biophysics group; (head: Prof. Tia Keyes) at the School of Chemical Sciences and National Centre for Sensor Research, Dublin City University, Ireland.

The aim of the doctoral project is to synthesise and optimize lipid membrane associating/partitioning triplet acceptors. The candidate will carry out synthesis, purification and characterisation of novel organic and inorganic luminescent sensor probes and their lipid conjugates optimized for high fluorescence quantum yield and triplet acceptor state energy. During the project the student will gain experience in organic and inorganic synthesis and purification methods, photophysics, and spectroscopy. The candidate will also work with partners to integrate the sensitizer into a triplet-triplet annihilation upconversion (TTA-UC) assembly and through support from theoretical calculations/computation optimize the performance of such assemblies.

Secondments: 2 months at Leibniz-IPHT/Germany, 3 months at UL/Netherlands, 2 months at the company Mimentas/Netherlands.

Requirements: Masters degree in Chemistry and good knowledge, experience and a strong interest in organic synthetic chemistry. Interest in the field of photochemistry/photophysics is essential and knowledge in spectroscopy, electrochemistry, liposomes and bioconjugation would be an advantage.

Planned start date: 1st April 2019

Application deadline: 31st January 2019

Contact:

Applications should be sent to Ms. Sheila Boughton: sheila.boughton@dcu.ie

Informal enquiries may be addressed to Prof. Tia Keyes at tia.keyes@dcu.ie

 

ESR2: Supramolecular Logic Gates in Supported Lipid Membrane Models (DCU)

Candidates with a background in chemistry, (bio)chemistry, biophysics or related disciplines are invited to apply for a PhD position in Supramolecular Biophysics group; (head: Prof. Tia Keyes) at the School of Chemical Sciences and National Centre for Sensor Research, Dublin City University, Ireland.

The aim of the doctoral project is to build robust fluidic lipid membrane models into which photoactive supramolecular assemblies are reconstituted. The candidate will build microfluidic lipid membrane models and assemble photoactive membrane associating constituents of molecular sensors into the substrates and will assess the performance of the sensors in the model. He/she will investigate the role of the tail group in optimising membrane re-constitution of supramolecular components and the photophysics of the assemblies using fluorescence lifetime imaging and fluorescence correlation spectroscopy of the molecular sensors and will elucidate the role of different lipid environments on the photophysics and sensor properties of the assemblies. The candidates experience will include nanofabrication, lipid membrane/liposome biophysics, and fluorescence microscopy.

Secondments: 2 months at Leibniz-IPHT/Germany, 3 months at UL/Netherlands and one month at the company SciClus/Germany

Requirements: Masters degree in Chemistry, Biochemistry, Biophysics or related discipline. Good knowledge and interest in both experimental and theoretical work. Interest in the field of photochemistry, photophysics and Biophysics and/or nanofabrication is required. Knowledge in the field of electrochemistry, self-assembled monolayers, liposomes and/or Langmuir Blodgett method are great assets.

Planned start date: 1st April 2019

Application deadline: 31st January 2019

Contact:

Applications should be sent to Ms. Sheila Boughton: sheila.boughton@dcu.ie

Informal enquiries may be addressed to Prof. Tia Keyes at tia.keyes@dcu.ie

 

ESR3: Quantum chemical investigation of absorption and emission properties of molecular sensors: from solution to complex environments (GUT)

Candidates with a background in physics and/or chemistry are invited to apply for a PhD position in the department of Theoretical Physics and Quantum Information (head: Prof. J. E. Sienkiewicz) at Gdansk University of Technology (GUT, Poland).

The aim of the doctoral project is to investigate the relationship between the structures and emission properties of molecular sensors using theoretical chemistry methods. Additionally, the project aims to estimate the effects of the interaction with a complex environment. The candidate will identify suitable methods to describe the structure, energies, absorption and emission spectra of molecular sensors in solution. The obtained results will be assessed by comparison with experimental data provided by the network partners. Then, the fellow will provide theoretical predictions concerning the changes in emission properties occurring due to analyte binding and due to the interaction with a surrounding solvent and a membrane model. In a first step, the environment will account for specific solvent/ion interactions with the molecular sensor using e.g. QM/MM approaches. In a second step, the environment will be extended to membrane models jointly with the partners DCU and SciClus.

Secondments: 1 month at DCU/Ireland, 3 months at the company SciClus/Germany and one month at the company COSMOlogic/Germany.

Requirements: Master/Engineering degree in Physics or Chemistry, preferably with majors in Theory or Quantum Chemistry. Good knowledge and interest in both experimental and theoretical work. Interest in the field of photochemistry, photophysics and theoretical chemistry is required. Knowledge in the field of computational quantum chemistry, molecular modelling, spectroscopy are great assets.

Planned start date: 1st May 2019

Application deadline: 28th February 2019

Contact: Applications should be sent to dr Julien Guthmuller at julien.guthmuller@pg.edu.pl

 

ESR4: Developing strategies to account for complex environments: from solution to membranes and cells (SCI)

Candidates with a background in physics, chemistry, or informatics are invited to apply for a PhD position in the company SciClus GmbH&Co. KG (heads: Dr. Burkhard Jahn and Dr. Martin Presselt).You will be employed and do research at SciClus in Jena. In addition you will be registered at Friedrich Schiller University Jena (FSU) to obtain the PhD degree.

The aim of the doctoral project is to identify methods that are best suited (fastest at sufficient accuracy) to account for the influence of solvents and electrolytes, particularly specific interactions beyond continuum models, on absorption and fluorescence spectra as well as fluorescence lifetimes. The candidate will study interactions between molecules and environments at systematically varied model complexities. Thus, the fellow will be able to apply the most suitable models to predict optimum molecular functionalizations for ideal anchoring of dyes in membranes. Beyond such thermodynamical calculations on molecular ground states the candidate will model the influence of such dye-environment interactions on properties of photoexcited states, particularly fluorescence spectra and lifetimes.

Secondments: one month each at UL/Netherlands and DCU/Ireland, one month at GUT/Poland and 3 months at the company COSMOlogic/Germany.

Requirements: Master/Engineering degree in Physics, Chemistry or Informatics, preferably with majors in theoretical chemistry, theoretical physics, or computational materials modelling. Good knowledge and interest in both experimental and theoretical work. Interest in the field of photochemistry, photophysics and molecular modelling is required. Knowledge in the field of (bio)chemical sensing, quantum chemistry are great assets.

Planned start date: 1st May 2019

Application deadline: 28th February 2019

Contact: Applications should be sent to Dr. Martin Presselt at martin.presselt@SciClus.de

 

ESR5: Photo-induced excited-state properties of molecular sensors and supramolecular logic gates in solution and membrane models (Leibniz IPHT)

Candidates with a background in physics, chemistry, photonics or optical engineering are invited to apply for a PhD position in the department of Functional Interfaces (head: Prof. Benjamin Dietzek) at Leibniz Institute of Photonic Technology (Leibniz-IPHT Jena, Germany).

The aim of the doctoral project is to elucidate the structure-function relationship of molecular sensors and their supramolecular assemblies using steady-state and time-resolved spectroscopy. The candidate will study photo-induced excited-state processes, such as energy and electron transfer, emission quenching by specific interactions in the isolated chemosensors in solution and incorporated into supramolecular vesicles. To tailor the optical properties of the sensors by molecular design, the fellow will perform systematic studies of their excited-state properties in various model environments, e.g. as a function of ionic strength, presence of biomacromolecules and pH. Thereby, specific and non-specific intermolecular interactions will be detailed, which impact the optical response of the chemosensors aside from the presence of specific ions to be sensed.

Secondments: 2 months at DCU/Ireland, 2 months at UL/Netherlands and one month at the company SciClus/Germany.

Requirements: Master/Engineering degree in Physics, Chemistry or Optical Engineering, preferably with majors in Spectroscopy. Good knowledge and interest in both experimental and theoretical work. Interest in the field of photochemistry, photophysics and time-resolved optical spectroscopy is required. Knowledge in the field of (bio)chemical sensing, quantum chemistry are great assets.

Planned start date: 1st May 2019

Application deadline: 28th February 2019

Contact: Applications should be sent to Prof. Benjamin Dietzek at benjamin.dietzek@leibniz-ipht.de

Click here for details.

 

ESR6: Transient absorption microscopy of a lab-on-a-vesicle in vitro and ex-vivo (Leibniz IPHT)

Candidates with a background in physics, (bio)chemistry, photonics or optical engineering are invited to apply for a PhD position in the department of Functional Interfaces (head: Prof. Benjamin Dietzek) at Leibniz Institute of Photonic Technology (Leibniz-IPHT Jena, Germany).

The aim of the doctoral project is to study molecular logic gates and their supramolecular assemblies (lab-on-a-vesicle) in endothelial cells using time-resolved (micro)spectroscopic methods, i.e. transient absorption microscopy. The candidate will investigate spatially resolved photophysics of the molecular sensors and lab-on-a-vesicle in endothelial cells and ex-vivo arteries of small animals and thus elucidate the role of different local environments on the photophysics and the resultant optical properties. During the project he/she will gain first spectroscopic insights into the excited-state processes of isolated and vesicle-integrated molecular chromophores when embedded into a biological environment. The photophysical properties immediately after uptake of the vesicles into the cells / the tissue will be characterised using time-lapse experiments.

Secondments: 2 months at DCU/Ireland, one month  at JUK/Poland, 2 months at the company Mimetas and one month at SAS/Slovakia

Requirements: Master/Engineering degree in Physics, (Bio)Chemistry or Optical Engineering, preferably with majors in Spectroscopy. Good knowledge and interest in both experimental and theoretical work. Interest in the field of photochemistry, photophysics and time-resolved optical spectroscopy is required. Knowledge in the field of (bio)chemical sensing, cell biology are great assets.

Planned start date: 1st July 2019

Application deadline: 30th April 2019

Contact: Applications should be sent to Prof. Benjamin Dietzek at benjamin.dietzek@leibniz-ipht.de

Click here for details.

 

ESR7: Molecular sensors for calcium ion detection at lipid membranes via triplet-triplet annihilation upconversion (UL)

Candidates with a background in synthesis, photochemistry, sensing, and/or bioinorganic chemistry, are invited to apply for a PhD position in the department of Metals in Catalysis, Biomimetics, and Inorganic Materials (MCBIM, sub-group Dr. Sylvestre Bonnet) at Leiden Institute of Chemistry (Leiden University, The Netherlands).

The aim of the doctoral project is to develop an upconversion sensing platform based on liposomes for the detection of calcium ions. The candidate will synthesize blue-emitting amphiphilic molecules that can bind to lipid bilayers and to calcium ions. Insertion of these molecules in liposomes, together with triplet sensitizers, will provide upconverting liposomes that can detect the presence of calcium ions in biological fluids surrounding the membrane. The sensitivity of such supramolecular logic sensors for Ca2+ ions to the presence of dioxygen and antioxidants, will be evaluated.

Secondments: 3 months at Leibniz IPHT/Germany, and 2 months at the company SciClus/Germany

Requirements: Master/Engineering degree in Chemistry. Good knowledge and interest in both synthetic and physical-chemical work. Proven competence in the field of synthesis, spectroscopy, or bioinorganic chemistry, is required. Knowledge in the field of (bio)chemical sensing, quantum chemistry are great assets.

Planned start date: 1st April 2019

Application deadline: 31st January 2019

Contact: Applications should be addressed to Dr. Sylvestre Bonnet and sent at snellenbergy@chem.leidenuniv.nl with the subject “application LOGICLAB”. Informal enquiries may be addressed to Dr. Sylvestre Bonnet at bonnet@chem.leidenuniv.nl

Click here for more details.

 

ESR8: Functionalization of living endothelial cells with TTA-UC logic gates and photo-NORMs (UL)

Candidates with a background in synthesis, photochemistry, chemical biology, and/or bioinorganic chemistry, are invited to apply for a PhD position in the department of Metals in Catalysis, Biomimetics, and Inorganic Materials (MCBIM, sub-group Dr. Sylvestre Bonnet)  at Leiden Institute of Chemistry (Leiden University, The Netherlands).

The ESR will study the influence of hydrophobic substituents on the membrane/water partition coefficient, bi-dimensional diffusion coefficient, and cellular toxicity, of photoactive NO-releasing molecules (photoNORMs) and upconverting molecular logic gated sensors. The project involves synthesis and physical chemistry; its overall objective is to obtain molecular sensors and photoNORMs that can be integrated in liposomes formulation that can be used to functionalize living endothelial cells with the sensing or NO-release function.

Secondments: 3 months at DCU/Ireland, 2 months at FSU/Germany and one month at the company Mimetas/Netherlands

Requirements: Master/Engineering degree in Chemistry. Good knowledge and interest in both synthetic and physical-chemical work. Proven competence in the field of synthesis, spectroscopy, chemical biology, or bioinorganic chemistry, is required. Knowledge in the field of (bio)chemical sensing, membrane (bio)chemistry are great assets.

Planned start date: 1st July 2019

Application deadline: 30th April 2019

Contact: Applications should be addressed to Dr. Sylvestre Bonnet and sent at snellenbergy@chem.leidenuniv.nl with the subject “application LOGICLAB”. Informal enquiries may be addressed to Dr. Sylvestre Bonnet at bonnet@chem.leidenuniv.nl

 

ESR9: Localization and interactions of labs-on-a-vesicle with subcellular structures in endothelial pathology models in vitro (JUK)

Candidates with a background in chemistry, biochemistry and/or spectroscopy are invited to apply for a PhD position in the Raman Imaging Group (head: Prof. Malgorzata Baranska) in the Faculty of Chemistry at Jagiellonian University (JUK, Krakow, Poland).

The aim of the doctoral project is to elucidate response of supramolecular logic gates (labs-on-a-vesicle) in cellular models of endothelial pathology in order to characterize them in in vitro conditions and evaluate its applicability in in vivo studies. The candidate will determine the distribution of labs-on-a-vesicle in endothelial cells using multimodal (Raman/fluorescence) imaging in vitro in a model of endothelial pathology in order to elucidate their transport, localization and interactions with subcellular structures. As a prerequisite of this step, biochemical markers of a studied endothelial pathology will be determined. To further examine activity of labs-on-a-vesicle, response of the system on light-triggered NO-release molecules will be investigated using the multimodal imaging approach.

Secondments: 2 months at UL/Netherlands, one month at DCU/Ireland and one month at the company Mimetas/Netherlands

Requirements: Master/Engineering degree in Chemistry or Biochemistry, preferably with majors in Spectroscopy. Good knowledge and interest in both experimental and theoretical work. Interest in the field of spectroscopy, microscopy and chemometrics applied to biological samples is required. Knowledge in the field of (bio)chemical sensing, endothelial biochemistry are great assets.

Planned start date: 1st June 2019

Application deadline: 28th February 2019

Contact: Applications should be sent to Prof. Malgorzata Baranska at baranska@chemia.uj.edu.pl. Please, insert “LogicLab PhD” as the e-mail title.

ESR10: Multimodal imaging of supramolecular logic gates in endothelial pathology models ex vivo (JUK)

Candidates with a background in chemistry, biochemistry and/or spectroscopy are invited to apply for a PhD position in the Raman Imaging Group (head: Prof. Malgorzata Baranska) in the Faculty of Chemistry at Jagiellonian University (JUK, Krakow, Poland).

The aim of the doctoral project is to determine response of supramolecular logic gates (labs-on-a-vesicle) in endothelial pathology models ex vivo in order to evaluate influence of tissue environment on labs-on-a-vesicle behaviour. The candidate will investigate tissue samples from animals in murine models of endothelial pathologies (for example atherosclerosis and/or hypertension) using multimodal (Raman/fluorescence) imaging to correlate Raman signals (information about chemical changes in the tissue) with luminescence signals from supramolecular logic gates. To get additional information about the activity of labs-on-a-vesicle in ex vivo models, response to light-triggered NO-release molecules will be evaluated. The comparison of the obtained results with data regarding in vitro models will enable to understand the influence of intermolecular interactions on spectral properties of labs-on-a-vesicle.

Secondments: 2 months at SAS/Slovakia, one month at the company Interscience/Netherlands and 2 months at UL/Netherlands

Requirements: Master/Engineering degree in Chemistry or Biochemistry, preferably with majors in Spectroscopy. Interest in the field of spectroscopy, microscopy and chemometrics applied to biological samples is required. Knowledge in the field of (bio)chemical sensing and endothelial biochemistry are great assets.

Planned start date: 1st June 2019

Application deadline: 28th February 2019

Contact: Applications should be sent to Prof. Malgorzata Baranska at baranska@chemia.uj.edu.pl. Please, insert “LogicLab PhD” as the e-mail title.

 

ESR11: Metabolomics of vascular function (UL)

Candidates with a background in analytical chemistry, mass spectrometry, chemistry, biochemistry and/or pharmacology are invited to apply for a PhD position in the Leiden Academic Centre for Drug Research (Analytical BioSciences and Metabolomics Group at the Division of Systems Biomedicine and Pharmacology; lead: Prof. Thomas Hankemeier) at Leiden University, The Netherlands.

The aim of your PhD project is to develop an advanced analytical platform for metabolic phenotyping of vascular function for blood vessels-on-a-chip. You will establish miniaturized metabolomic setups to profile metabolites from in-vitro as well as ex-vivo cell experiments and develop methods for the functional metabolic assessment of endothelial function, which includes oxidative/nitrosative stress, endothelial activation and inflammation. Blood samples from animal models with defined endothelial phenotypes will serve as reference, and blood will be perfused through blood vessels-on-a-chip. You will use tracer-based metabolomics technique, and you will aim to study individual cells in your organ-on-a-chip models. To validate results, you will analyse metabolic profiles in combination with other phenotypic readout and omics and sensors. Finally, you will aim to translate the developed strategies into a diagnostic assay to screen blood samples using metabolomics and blood vessels-on-a-chip. To achieve your goals, you will collaborate with several other PhD students in this ITN program.

Secondments: one month each at SAS/Slovakia and at the company MatTek In Vitro Life Science Laboratories s.r.o./Slovakia, 3 months at the company Interscience/Netherlands

Requirements: Master/Engineering degree in Chemistry, Biochemistry, Biology or Biomedical Engineering preferably with majors in Analytical Chemistry. Interest in the field of metabolomics, pharmacology, microfluidics and chemometrics applied to biological samples is desired. Knowledge in the field of (bio)chemical sensing and endothelial biochemistry are great assets.

Planned start date: 1st July 2019

Application deadline: 30th April 2019

Contact: Applications should be sent to Prof. Dr. Thomas Hankemeier at hankemeier@lacdr.leidenuniv.nl and Dr. Amy Harms at a.c.harms@lacdr.leidenuniv.nl.

 

ESR12: Toxicology of logic gates and evaluation of logic gates in an in-vitro blood-brain barrier model and ex-vivo (SAS)

Candidates with a background in cell biology, toxicology, biochemistry, chemistry, molecular biology or related fields are invited to apply for a PhD position in the department of Cell Pharmacology and Developmental Toxicology (head: Dr. Mojmír Mach) at the Institute of Experimental Pharmacology and Toxicology, Centre of Experimental Medicine, Slovak Academy of Sciences.

The topic of PhD study will focus on evaluation of cytotoxicity and applicability of novel fluorescent reporters designed for simultaneous multicolour detection of reactive nitrogen (RNS) and reactive oxygen species (ROS) at the cellular level. The cytotoxicity will be evaluated by standard assays (such as MTT, neutral red uptake assay or cell cycle analysis) in the cellular models (microglia, fibroblasts, endothelial cells). The probes specificity will be evaluated in cell and cell-free systems exposed to different ROS and RNS as well as in the systems simultaneously generating these species (such as LPS-stimulated microglia, as the brain resident macrophages) using fluorescence-based methods. The probe applicability will be validated in such cellular models as microglia or brain microvascular endothelial cells. The methods based on novel molecular logics will be compared with standard methods of detection of RNS and ROS and confronted with biological consequences and signalling pathways of RNS and ROS generation (such as the expression of iNOS protein or proteins involved in regulation of the endothelial function).

Secondments: one month at University of Leiden/Netherlands, 2 months at the company Mimetas/Netherlands and 2 months at Jagiellonian University of Krakow /Poland

Requirements: Master/Engineering degree in Biochemistry, Pharmacology, Chemistry or related sciences. Good knowledge and interest in both experimental and theoretical work. Interest in the field of cell biology is required. Knowledge in the field of ROS-sensitive probes are great assets.

Planned start date: 1st June 2019

Application deadline: 31st March 2019

Contact: Applications should be sent to Dr. Mojmir Mach at mojmir.mach@savba.sk

 

ESR13: Development of a healthy and diseased microfluidic artery model (artery-on-a-chip) in OrganoPlates® (MIM)

Candidates with a background in cell biology, molecular biology and/ or chemistry are invited to apply for a PhD position in the department of model development (head Dr H Lanz) at MIMETAS B.V. Leiden, The Netherlands. You will be employed and do research at MIMETAS B.V. Leiden. In addition you will be registered at the University Leiden (UL) to obtain the PhD degree.

The aim of the doctoral project is to develop a healthy and diseased microfluidic artery model (artery-on-a-chip) in OrganoPlates® and to incorporate sensors and supramolecular logic gates in this model to establish new tools for biomedical research. Organ-on-chips are microfluidic devices for culturing living cells in continuously perfused, micrometer-sized chambers, such that they maintain tissue- and organ-level functions. A stable healthy artery-on-a-chip model will be developed. The candidate will induce endothelial dysfunction in this healthy artery model to get a diseased artery-on-a-chip model. Sensors and supramolecular logic gates, such as fluorescent sensor for ED-relevant analytes (NO/O2 and shear stress) or theranostic system, will be evaluated in the artery-on-a-chip models under static and flow conditions. The candidate will discriminate healthy and diseased artery models using these molecular logic sensors.

Secondments: 2 months at UL/Netherlands, 2 months at JUK/Poland and one month at DCU/Ireland

Requirements: Master degree in Cell Biology, Molecular Biology and/or Chemistry. The candidate should have interest in developing and translating technology to establish new tools for biomedical research. The candidate should have good knowledge of (3D) cell culture and laboratory equipment such as microscopes and plate readers. Knowledge in the field of Organ-on-a-chip are great assets. He/she should be able to communicate with scientists and engineers of different disciplines and have a motivated, flexible and positive work attitude.

Planned start date: 1st April 2019

Application deadline: 31st January 2019

Contact: Applications should be sent to ​Ms Esther Groenewoud at work@mimetas.com. Informal enquiries may be addressed to Dr Lenie van den Broek at l.vandenbroek@mimetas.com

 

ESR14: Synthesis and characterization of upconversion-based NO-releasing molecules (FSU)

Candidates with a background in chemistry are invited to apply for a PhD position in the Institute of Physical Chemistry (subgroup: Molecular Photonics; lead: Prof. Benjamin Dietzek) at Friedrich Schiller University (Jena, Germany).

The aim of the doctoral project is to synthesise metal complexes, which show light-triggered release of therapeutic doses of NO (photo-NORMs) and evaluate them in solution, lipid membranes and in cells (in-vitro). The candidate will develop different strategies to synthesise photo-NORMs and optimise the molecules for perspective application as therapeutic agents for endothelial dysfunction. Therefore, he/she will study the NO-release of photo-NORMs in solution, characterise the photo-induced processes and incorporate photo-NORMs together with NO sensor molecules in liposome carrier systems to form a novel supramolecular theranostic system, which will be tested in cell (co)-cultures, artery-on-a-chip or ex-vivo arteries.

Secondments: 2 months at the company SciClus/Germany, one month at UL/Netherlands and 2 months at JUK/Poland

Requirements: Master degree in Chemistry, with majors in synthetic Inorganic/Organic Chemistry. Preferably, the candidate is experienced in the spectroscopic characterisation of molecular compounds. Interest in the field of photochemistry and photophysics are beneficial.

Planned start date: 1st July 2019

Application deadline: 30th April 2019

Contact: Applications should be sent to Prof. Benjamin Dietzek at benjamin.dietzek@uni-jena.de. Informal enquiries may be addressed to Dr. Martin Schulz at martin.schulz.1@uni-jena.de

Click here for more details.

Benefits

You will receive a contract of employment as a full-time researcher for the relevant period of your appointment, which will include applicable benefits in the host country. Highly competitive and attractive salaries according to regulations of Marie Skłodowska-Curie Actions are offered, plus mobility and family allowances as applicable. The grant and salary, including social security coverage, is described on the following webpage:http://ec.europa.eu/research/mariecurieactions/actions/research-networks_en

The successful candidate will be part of an excellent international research team and benefit from the scientific and complementary training programme of the EU-funded Innovative Training Network, Logic Lab.

Funding of the position through the MSCA-ITN is limited to 36 Months.

Eligibility criteria

Candidates will be required to meet the Marie Skłodowska-Curie Early Stage Researcher eligibility criteria:

In particular, at the time of appointment candidates must have had less than four years full-time equivalent research experience and must not have already obtained a PhD. Additionally, they must not have resided in the host country for more than 12 months in the three years immediately before the appointment. (http://ec.europa.eu/research/mariecurieactions/)

Selection process

The ESRs will be recruited according to the European Charter and Code for Researchers in an open, efficient and transparent procedure, that is supportive and internationally comparable, as well as tailored to the type of positions advertised.

The selection is made by the host principal investigators and co-supervisors, who bring together diverse expertise and competences. Whenever possible, the selection committee will have an adequate gender balance. Practices used are face-to-face interviews at the host location or interviews via Skype.

 

 

 

 

Additional comments

These offers are within the framework of ITN Logic Lab, which offers challenging and exciting research positions in an international, multidisciplinary and intersectoral research network. All ESRs will be enrolled in a PhD programme of the local University. All academic and industrial supervisors in Logic Lab network are internationally renowned leaders in their respective fields. As a fellow, you will benefit from opportunities offered by your host employer and the whole Logic Lab network, made up of 9 partners representing different aspects molecular logic sensing from chemosensor synthesis, spectroscopic and quantum chemical characterisation to application in organ-on-a-chip platforms and biomedical research. 

Web site for additional job details

Required Research Experiences

  • RESEARCH FIELD
    Chemistry
  • YEARS OF RESEARCH EXPERIENCE
    1 - 4
  • RESEARCH FIELD
    Biological sciences
  • YEARS OF RESEARCH EXPERIENCE
    1 - 4
  • RESEARCH FIELD
    Physics
  • YEARS OF RESEARCH EXPERIENCE
    1 - 4
  • RESEARCH FIELD
    Engineering
  • YEARS OF RESEARCH EXPERIENCE
    1 - 4

Offer Requirements

  • REQUIRED EDUCATION LEVEL
    Chemistry: Master Degree or equivalent
    Biological sciences: Master Degree or equivalent
    Physics: Master Degree or equivalent
    Engineering: Master Degree or equivalent
  • REQUIRED LANGUAGES
    ENGLISH: Excellent

Skills/Qualifications

The application must be accompanied with the following documents in PDF format:

• letter of motivation,

• curriculum vitae of at most 3 pages, including well-identified publication list

• transcripts of records from University/University College and copy of your degree

• copy of master’s thesis or any other publications (if available),

• two written recommendation letters (e.g. one by your Master thesis supervisor) and the referees contact details

 

Specific Requirements

The candidate should have excellent communication skills in English (both in speaking and writing), should be able to work both in a team and independently, should demonstrate initiative and should be proactive in the project.

Map Information

Work location(s)
2 position(s) available at
Leibniz-Institute of Photonic Technology
Germany
Jena
Albert-Einstein-Str. 9
2 position(s) available at
Dublin City University
Ireland
Dublin
Glasnevin, Dublin 9
3 position(s) available at
University of Leiden
Netherlands
Leiden
1 position(s) available at
Mimetas B.V.
Netherlands
Leiden
1 position(s) available at
Friedrich Schiller University Jena
Germany
Jena
1 position(s) available at
SciClus GmbH&Co KG
Germany
Jena
1 position(s) available at
Centre of Experimental Medicine of the Slovak Academy of Sciences
Slovakia
Bratislava
2 position(s) available at
Jagiellonian University of Krakow
Poland
Krakow
1 position(s) available at
Gdansk University of Technology
Poland
Gdansk

EURAXESS offer ID: 359435