18/11/2018
The Human Resources Strategy for Researchers
Marie Skłodowska-Curie Actions

Early Stage Researcher (PhD position) opportunity in Synthetic Glycobiology – ESR1: Engineering multimeric lectin complexes for membrane fusion

This job offer has expired


  • ORGANISATION/COMPANY
    The University of Leeds
  • RESEARCH FIELD
    ChemistryBiochemistry
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
  • APPLICATION DEADLINE
    07/01/2019 23:00 - Europe/London
  • LOCATION
    United Kingdom › Leeds
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    37.5
  • EU RESEARCH FRAMEWORK PROGRAMME
    H2020 / Marie Skłodowska-Curie Actions
  • REFERENCE NUMBER
    synBIOcarb ESR1
  • MARIE CURIE GRANT AGREEMENT NUMBER
    814029

Are you keen to progress research in glycoscience at the interface between chemistry, biology and physics, in the first four years of your research career and based outside the UK? Do you want to further your career and attain a PhD in one of the UK’s leading research intensive universities?

synBIOcarb is a Marie Skłodowska-Curie Innovative Training Network. It brings together 14 leading European partners in a transnational network, implementing a multidisciplinary and intersectorial research and training programme between the academic and the industrial partners in the fields of synthetic glycobiology.

Together, we will provide 15 early stage researchers (ESRs) with advanced scientific training in chemical synthesis, protein engineering, biophysics, cell biology and analytical device technologies that underpin the development and exploitation of glycoscience for diagnostics and targeted drug delivery. Each ESR will contribute to one, or more, of four thematic work packages that have been designed to progress the state of the art in Synthetic Glycobiology.

As an Early Stage Researcher in Leeds, you will undertake research in re-engineering bacterial toxin proteins and other carbohydrate-binding proteins to mediate membrane fusion for drug delivery applications.

All cells are coated with complex carbohydrates and many viruses, bacteria and protein toxins produced by bacteria exploit this sugar coating as a means of binding to and entering their target cells. We have recently developed methods for the site-specific chemical, enzymatic and genetic modification of cholera toxin to make non-toxic delivery vehicles that can carry large cargoes into cells. We have also developed methods which enable the re-engineered proteins to initiate membrane fusion. In this project you will investigate how changes in the structure of the proteins affects and controls vesicle crosslinking and fusion. You will develop new protein tools for crosslinking and fusing together vesicles and cells that are coated in different types of sugars. Through this interdisciplinary project you will develop skills in protein engineering and molecular biology; site-specific chemical modification of proteins; biophysical techniques for measuring the affinity for molecular interactions; fluorescence imaging techniques for studying membrane interactions. Appropriate training will be provided in all areas that are new to the researcher.

The successful candidate will participate in the network’s training activities and work placements at the laboratories of the synBIOcarb academic and industrial teams. Regular meetings and workshops within the EU-funded synBIOcarb Innovative Training Network will supplement the training and support provided at the University of Leeds. Practical scientific training will be complemented by a coordinated programme of industry-relevant transferable skills that will prepare the ESRs for future careers in the medical technologies sector.

To meet the requirements of the Marie Skłodowska-Curie Innovative Training Network, you will be an early stage researcher within the first four years of your research career, have not yet been awarded a doctoral degree (PhD), and have not lived or carried out your main activity (work/study) in the UK for more than 12 months during the past three years.

Benefits

This position is for 36 months. The Early Stage Researcher will be contractually employed by the University of Leeds. He or she will receive a Monthly Living Allowance plus a Mobility Allowance compliant with the applicable EC Marie Skłodowska-Curie Actions-ITN general conditions.

The Marie Skłodowska-Curie Early Stage Researcher living and mobility allowance is fixed at €48,452 per annum (plus family allowance if applicable). This amount will be subject to tax and National Insurance deductions, and will be paid in UK Sterling (£) using an appropriate conversion rate.

Eligibility criteria

 

    Selection process

    Application procedure

    • You are required to apply to this post via the application webpage. Applications should be submitted on the advertised closing date.

    • In the supporting statements section, it is important to give specific examples for how you meet each criterion. As part of the online process, you will also need to upload a cover letter outlining why you want to join the project, a CV including the names and contact details of at least 2 references, and transcripts of your university record.

    • Informal inquiries can be made by email to w.b.turnbull@leeds.ac.uk indicating reference ‘synBIOcarb ESR1’ in the subject.

    Additional comments

    This post will be based in the laboratory of Prof Bruce Turnbull which belongs to the School of Chemistry (Faculty of Maths & Physical Sciences), and the Astbury Centre for Structural Molecular Biology. You will collaborate with the laboratory of Dr. Ralf Richter which belongs to the School of Biomedical Sciences (Faculty of Biological Sciences), the School of Physics (Faculty of Mathematics and Physical Sciences), which is also part of the Astbury Centre.

    Offer Requirements

    Skills/Qualifications

    Applicants should bring skills/qualifications and meet eligibility criteria as follows:

    • Have a Diploma and/or a Master Degree in chemistry, biochemistry or a closely related subject.
    • Have less than 4 years research experience at the signature of the contract (measured from the time the Master’s degree has been obtained).
    • Not have a PhD already.
    • Not have resided or carried out main activity in the United Kingdom for more than 12 months in the last 3 years immediately prior to the reference recruitment date.
    • Excellent knowledge of the English language (spoken and written / proficiency level).
    • Training on required laboratory techniques will be provided through the synBIOcarb network. However, practical experience in protein chemistry would be advantageous.

    Work location(s)
    1 position(s) available at
    The University of Leeds
    United Kingdom
    Leeds
    LS2 9JT
    Woodhouse Lane

    EURAXESS offer ID: 356308

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