09/11/2018
Marie Skłodowska-Curie Actions

Marie Curie Early Stage Researcher position (PhD programme) in the frame of the NanoCarb subproject: “Glycan-coated nanoparticles as inhibitors of specific lectins, a new neuroprotective therapeutic strategy for brain injury caused by ischemia”.


  • ORGANISATION/COMPANY
    Istituto di Ricerche Farmacologiche Mario Negri IRCCS
  • RESEARCH FIELD
    Pharmacological sciencesOther
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
  • APPLICATION DEADLINE
    15/01/2019 12:00 - Europe/Brussels
  • LOCATION
    Italy › Milan
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    40
  • OFFER STARTING DATE
    01/04/2019
  • EU RESEARCH FRAMEWORK PROGRAMME
    H2020 / Marie Skłodowska-Curie Actions
  • MARIE CURIE GRANT AGREEMENT NUMBER
    814236

General framework

A call for 15 PhD positions (Early Stage Researchers [ESRs]) is open in the recently granted Marie Curie European Training Network (MC-ETN) project NanoCarb - Glyco-Nanoparticles for Applications in Advanced Nanomedicine. NanoCarb is a multidisciplinary consortium including universities, research centres and SMEs with broad expertise ranging from Nanotechnology, Carbohydrate Chemistry, Glycobiology and in vitro/in vivo screening specialists. The network will develop novel and well-characterised nanomaterials with synthetic and native glycans that will be used for therapeutics and guide development of new drug delivery applications. The project will train early stage researchers at the interface of nanotechnology and glycosciences, with the overall goal of achieving a new generation of professionals in nanomedicine for a prospective career in both academia and industry. For further information on the project please go to www.nanocarb.eu.

The successful candidates will profit of an international scientific network of high profile academic and industry partners and will receive excellent training in the form of hands-on-instructions, training through research. An ambitious training plan will be implemented including courses, outreach activities, participation in seminar, and workshops for the development of scientific and transferable skills.

Furthermore, each ESR will be supervised by an Industry-Academia supervisory team consisting of at least one supervisor from each field. ESRs will receive an attractive salary in accordance with the MSCA regulations for Early Stage Researchers http://ec.europa.eu/research/mariecurieactions/.

Position

A three-year PhD position, is available on the project “Glycan-coated nanoparticles as inhibitors of specific lectins, a new neuroprotective therapeutic strategy for brain injury caused by ischemia”.

This project is focused on the identification of glycan-coated nanoparticles capable to interact with high affinity with specific lectins involved in the lectin pathway of complement system, e.g. mannose-binding lectins and ficolins. These lectins have recently been suggested as potential targets for neuroprotective therapeutic strategies for ischemic brain injury [1-4], and the present project aims to test this working hypothesis by in vitro and preclinical studies.

These studies will be mainly carried out at the Mario Negri Institute for Pharmacological Research, Milan, Italy, under the supervision of Dr. Marco Gobbi, head of the laboratory of Pharmacodynamics and Pharmacokinetics, and Dr. Maria Grazia De Simoni, head of the laboratory of Inflammation and Nervous System Diseases.

Two secondments are planned, in both academic and industry environments.

The research project is highly multidisciplinary where the scholar will have the opportunity to gain knowledge in glycan chemistry, biochemistry, neuropharmacology, neuroimmunology, by developing and assessing smart nanoparticles for applications in nanomedicine.

The candidate will commit to carry out an independent and original scientific research, to report the research findings to the supervisor verbally and in the form of written report (1 per year) and to be assessed on a yearly based to test the advances in specific competencies, necessary for the PhD advancement and to do a final viva exam at the end of the 3rd year.

References

1) Orsini et al. (2012) Targeting mannose-binding lectin confers long-lasting protection with a surprisingly wide therapeutic window in cerebral ischemia. Circulation 126, 1484-14941.

2) Fumagalli and De Simoni (2016) Lectin complement pathway and its bloody interactions in brain ischemia. Stroke 47, 3067-3073

3) De Blasio et al., (2017) Pharmacological inhibition of mannose-binding lectin ameliorates neurobehavioral dysfunction following experimental traumatic brain injury. J Cereb Blood Flow Metab 37, 938-950

4) Stravalaci et al., (2016) A New Surface Plasmon Resonance Assay for In Vitro Screening of Mannose-Binding Lectin Inhibitors. J Biomol Screen 21, 749-757

Benefits

The successful candidates will profit of an international scientific network of high profile academic and industry partners and will receive excellent training in the form of hands-on-instructions, training through research. An ambitious training plan will be implemented including courses, outreach activities, participation in seminar, and workshops for the development of scientific and transferable skills.

Furthermore, each ESR will be supervised by an Industry-Academia supervisory team consisting of at least one supervisor from each field. ESRs will receive an attractive salary in accordance with the MSCA regulations for Early Stage Researchers http://ec.europa.eu/research/mariecurieactions/ .

 

Eligibility criteria

Eligible applicants must have less than 4 years research experience (Early Stage Researcher) and have not been awarded a doctoral degree.

Mobility rule: The applicants should not have resided or carried out main activity (studies, work, etc.) in Italy for more than 12 months in the 3 years prior to the recruitment date.

 

Web site for additional job details

Required Research Experiences

  • RESEARCH FIELD
    Biological sciencesOther
  • YEARS OF RESEARCH EXPERIENCE
    1 - 4

Offer Requirements

  • REQUIRED EDUCATION LEVEL
    Biological sciences: Master Degree or equivalent
    Neurosciences: Master Degree or equivalent
    Pharmacological sciences: Master Degree or equivalent
    Medical sciences: Master Degree or equivalent
  • REQUIRED LANGUAGES
    ENGLISH: Good

Skills/Qualifications

Basic background in biochemistry, immunology, neuroscience or nanotechnology;

Experience in performing laboratory work;

Strong interest in a research career and great attitude to work in-group and the capacity of applying a multidisciplinary approach in research and thinking. Good collaborative and social skills and an open-minded mind-set;

Map Information

Job Work Location Personal Assistance locations
Work location(s)
1 position(s) available at
Istituto di Ricerche Farmacologiche Mario Negri IRCCS
Italy
Milan
20156
Via G. La Masa 19

EURAXESS offer ID: 354125