Post-doctoral Position on Bacteriophage Infection of Gram-Positive Bacteria

Bacteriophage SPP1, like numerous eukaryotic viruses, establishes viral factories confined at specific locations of the host cell (J. Bacteriol. 193: 4893).

The project aims to pursue:
- the study of the bacterial cytoplasm spatial reorganization during bacteriophage infection
- the identification and caracterisation of viral proteins that hijack cellular functions and their bacterial targets. Infection at different stages of the B. subtilis cell cycle will be characterized (J. Virol. 89: 2875).

The approach is interdisciplinary, combining genetics, virus engineering and genome refactoring (e.g. Proc. Natl. Acad. Sci. USA 112: 7009), omics, and state of the art cell imaging techniques.

Study of the genetic basis of cellular and molecular mechanisms used by bacteriophages to infect the Gram-positive bacterium Bacillus subtilis.

The host team Bacteriophages of Gram-Positive Bacteria studies assembly of viral particles of tailed bacteriophages and infection of Gram-positive bacteria by these viruses (https://www.i2bc.paris-saclay.fr/spip.php?article580).
The team is associated to the Department of Virology at Institute of Integrated Biology of the Cell (http://www.i2bc.paris-saclay.fr/spip.php?article312) that provides a strong interdisciplinary environment for biological sciences research in the CNRS Campus of Gif-sur-Yvette (Paris region). The host Institute offers state of the art facilities for molecular biology, genomics, microbiology, advanced cell imaging, proteomics, and structural biology research.