30/10/2018
Marie Skłodowska-Curie Actions

Marie Skłodowska-Curie ITN-ETN Nanocarb. PhD position In vivo fate studies of glyco NPs and biocorona stability

This job offer has expired


  • ORGANISATION/COMPANY
    CICbiomaGUNE
  • RESEARCH FIELD
    ChemistryBiochemistry
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
  • APPLICATION DEADLINE
    31/01/2019 23:00 - Europe/Brussels
  • LOCATION
    Spain › San Sebastián
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    38
  • OFFER STARTING DATE
    01/03/2019
  • EU RESEARCH FRAMEWORK PROGRAMME
    H2020 / Marie Skłodowska-Curie Actions
  • REFERENCE NUMBER
    ESR14-315
  • MARIE CURIE GRANT AGREEMENT NUMBER
    814236

Description:

Applications are invited for one Marie Curie Early Stage Researcher (PhD) position in the frame of the Nanocarb project on in Radiolabelling, Pharmacokinetics and Biological fate of nanomaterials to be carried out under the supervision of Dr. Jordi Llop at CIC biomaGUNE in San Sebastian (Spain).

The European project Nanocarb (Glyco-Nanoparticles for Applications in Advance Nanomedicine) is a new Innovative Training Network (ITN) funded by the European Commission under the H2020 - MSCA-ITN-2018 programme.

NanoCarb is a multidisciplinary consortium including universities, research centres and SMEs with broad expertise ranging from nanotechnology, carbohydrate chemistry, glycoprofiling and in vitro/in vivo screening specialists. The network will develop novel and well-characterised nanomaterials with synthetic and native glycans that will be used for therapeutics and guide development of new drug delivery applications. The project will train early stage researchers at the interface of nanotechnology and glycosciences, with the overall goal of achieving a new generation of professionals in nanomedicine for a prospective career in both academia and industry.

The successful candidates will benefit from an international scientific network of high-profile academic and industry partners offering state-of-the-art research facilities in nanotechnology, carbohydrate chemistry, glycoprofiling and in vitro/in vivo screening as well as career relevant training through research, courses, outreach activities, participation in seminar, and workshops.

 

Job Full Description:

Nanomedicine is an interdisciplinary branch of medicine that uses tools and knowledge of nanoparticles (materials of 100nm or less in diameter) for applications in healthcare. In particular, nanoparticles offer new solutions in the therapeutics and diagnostics for drug delivery and enhanced imaging, necessary to detect and treat chronic diseases like cancer. Despite numerous exciting research findings the area of nanomedicine suffers from several drawbacks, and the translation from laboratory to clinical products is significantly lower than the expected pace. Molecular imaging techniques, and particularly Positron Emission Tomography (PET), could be helpful in bridging the gap between basic development and clinical application, as they offer unique opportunities for the in vivo and non-invasive investigation of pharmacokinetics and biological fate of nanomaterials.

The project seeks to find a highly motivated student to carry out a study focused on the preparation and characterization of gold nanoparticles with different shapes, functionalized with negatively charged glycans to prevent (or minimize) the formation of the protein corona. Radiolabelling strategies for the incorporation of positron emitters into the NPs will be developed, and the resulting nanosystems will be investigated in vivo in small rodents to evaluate the fate of the nanoparticles and the formation of the protein corona.

The successful PhD student will be trained in:

  • Nanoparticle synthesis, surface functionalization and characterisation with several techniques
  • Radichemistry and in vivo imaging
  • Animal experimentation

The research project is highly multidisciplinary and the candidate will develop knowledge in nanotechnology, radiochemistry, molecular imaging and animal experimentation.

The candidate will commit to carry out an independent and original scientific research, to report the research findings to the supervisor verbally but also in the form of written report and to be assessed on a yearly based to test the advances in specific competencies, necessary for the PhD advancement and to do a final viva exam at the end of the 3rd year.

 

Planned Secondments:

Università degli Studi di Milano, Milan, Italy (2 months)

Vlaamse Instelling voor Technologisch Onderzoek N.V., Mol, Belgium (3 months)

 

Eligibility:

Marie Curie eligibility rules requires ESRs to have at most four years of research experience. To satisfy Marie Curie mobility criteria, candidates must not have resided or carried out your main activity (work, studies, etc.) in Spain for more than 12 months in the 3 years prior to the start data (short stays such as holidays and/or compulsory national service are not taken into account).

Required Education Level: First Stage Researcher (R1)

Required Research Experience/Skills/Qualifications:

  • Master Degree in Chemistry or related areas.
  • Previous experience in radiochemistry, in vivo imaging or animal experimentation will be highly valued.
  • Strong interest in a research career.
  • Capacity of applying a multidisciplinary approach in research and thinking.
  • For candidates where English is not their first language: a high standard of written and spoken English is required.
  • Only highly motivated students to complete a challenging but exciting research project within 3 years must apply.

 

How To Apply: To apply please send following documents in one PDF-file using this form indicating as reference ESR14-315:

  • Updated Curriculum vitae inclusive of contact details of previous supervisors. (Max 3 pages)
  • Statement of interest and motivation in doing the PhD in this research field along with the description of your research skills, experience and publications and a brief description of the current expertise and the master thesis project (Max 3 page)
  • Recommendation letter(s) of your previous supervisors (Desirable). Alternatively the contact details of two academics who can provide a reference.

All applications will be handled confidentially. By submitting an application you consent to your application being shared with the other principle investigators of the NanoCarb consortium for the sole purpose of the candidate recruitment. Please note that only complete application sets will be considered. 

Work location(s)
1 position(s) available at
CICbiomaGUNE
Spain
San Sebastián
20014
Paseo Miramón 182

EURAXESS offer ID: 350965