13/09/2018
The Human Resources Strategy for Researchers
European Research Council
Science 4 Refugees

Post-doctoral Researcher in Organic Chemistry

This job offer has expired


  • ORGANISATION/COMPANY
    Université Libre de Bruxelles (ULB)
  • RESEARCH FIELD
    ChemistryCombinatorial chemistry
    ChemistryMolecular chemistry
    ChemistryOrganic chemistry
  • RESEARCHER PROFILE
    Recognised Researcher (R2)
  • APPLICATION DEADLINE
    03/11/2018 23:00 - Europe/Athens
  • LOCATION
    Belgium › Brussels
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    38
  • OFFER STARTING DATE
    01/01/2019
  • EU RESEARCH FRAMEWORK PROGRAMME
    H2020 / ERC

Job Summary

The Engineering of Molecular NanoSystems laboratory of the Université libre de Bruxelles (ULB) offers a two-year postdoctoral fellowship for a highly motivated organic chemist to work on the synthesis and development of supramolecular receptors for nucleotides.

 

Project

This fellowship is offered in the context of a project for excellent research funded by the European Research Council (ERC) aimed at the development of molecular transmembrane transporters for phosphorylated biomolecules.

In biology, lipid bilayer membranes function as impermeable barriers for ionic and hydrophilic species, which can only cross the membrane with the aid of dedicated membrane proteins. Synthetic organic compounds can also be used to transport ions of interest across membranes. They need to bind the ion in order to extract it from the aqueous phase into the bilayer, to then move across the membrane and to release the ion on the other side. The development of such mobile ion carriers is of interest for biochemical research and pharmaceutical or biotechnological applications.

The aim of the project is to develop synthetic anion receptors that are able to bind biologically relevant phosphorylated compounds, such as nucleotides. In the next stage of the project, the ability of these receptors to transport phosphates and nucleotides across membranes will be investigated.

 

Job description

The successful applicant will primarily work on the synthesis of receptors for phosphoryl groups and nucleotides. This involves the preparation of building blocks and their subsequent assembly into receptors using a Dynamic Combinatorial Chemistry approach. The methodology for this approach will be developed. The interactions between the synthesised receptors and phosphorylated guests will be investigated using various physicochemical methods including NMR, microcalorimetry, and optical spectroscopy.

The successful applicant will work closely with a PhD student and potential Master students, and be involved in their supervision. English and French are the languages spoken in the laboratory but all results will be disseminated in English (seminars, written reports, and articles). Participation in international conferences will be encouraged.

Benefits

The net amount of the fellowship will be ~€2400/month.

  • EU Citizens and citizens from countries that have a bilateral social security agreement with Belgium: social security coverage including medical insurance, unemployment benefit, retirement pension, maternity leave and child benefit.
  • Non-EU Citizens from countries that have no bilateral social security agreement with Belgium: social security coverage including medical insurance, maternity leave and child benefit.
  • Insurance against accidents in the workplace.
  • Tax exemption.
  • Low-cost private hospitalization insurance.
  • On-site services at the ULB: medical centre, university hospital, sports centre, subsidized restaurants, cultural centre, crèche, activities for children…

Eligibility criteria

  • Applicants of any nationality are eligible.
  • Eligible applicants hold a PhD degree which has been awarded maximum 8 years ago by the 1st of January 2019.
  • Eligible applicants must not have resided or carried out their main activity (work, studies, etc.) in Belgium for more than 24 months during the 3 years preceding the start of the fellowship.

Selection process

Applications should be sent by email to hennie.valkenier@ulb.ac.be no later than the 3rd of November 2018 and should include:

  • a cover letter motivating the application
  • a CV, including a list of publications and communications
  • contact details of two persons that can provide a reference

The selection procedure will start shortly after the 3rd of November.

Additional comments

Feel free to contact Dr. Hennie Valkenier (hennie.valkenier@ulb.ac.be) should you have any questions.

Offer Requirements

  • REQUIRED EDUCATION LEVEL
    Chemistry: PhD or equivalent
  • REQUIRED LANGUAGES
    ENGLISH: Excellent

Skills/Qualifications

  • Strong background in synthetic organic chemistry
  • Able to synthesise novel compounds and develop robust synthetic protocols
  • Experienced in the structural characterisation of organic compounds
  • Familiar with the concepts of Supramolecular Chemistry
  • Team worker
  • Creativity and problem-solving skills
  • Excellent communication skills in English
  • Excellent past achievements

Specific Requirements

Hands-on experience with Dynamic Combinatorial Chemistry, High Pressure Liquid Chromatography (HPLC), and Supramolecular Chemistry will be advantages.

Work location(s)
1 position(s) available at
Université libre de Bruxelles (ULB), Solbosch campus
Belgium
Brussels
1050
Avenue Paul Héger

EURAXESS offer ID: 338695