ORGANISATION/COMPANYInstitute of Biochemistry of the Romanian Academy
RESEARCH FIELDBiological sciences
RESEARCHER PROFILEFirst Stage Researcher (R1)Recognised Researcher (R2)
APPLICATION DEADLINE28/09/2018 16:00 - Europe/Athens
LOCATIONRomania › Bucharest
TYPE OF CONTRACTTemporary
HOURS PER WEEK40 hours per week (academic flexibility)
OFFER STARTING DATE15/10/2018
We are looking to hire one research assistant to carry out lifespan-modulating wet-lab experiments in C. elegans and to analyze the mechanisms of ageing. The successful candidate will join the Computational Biology of Aging Research Group in the Department of Bioinformatics and Structural Biochemistry. The post is funded by a EU POC-A1-A1.1.4-E- 2015 Competitiveness Operational Programme 2014-2020 award, for the development of a „Multi-omics prediction system for prioritization of gerontological interventions” (GERONTOMICS). The duration of the post is one year, extendable for up to 2 years, based on satisfactory performance. The selected candidate will work full-time in the project.
GERONTOMICS aims to use a systems biology approach to combine data from different “omics” levels (e.g.: genomic, transcriptomic, epigenomic, etc) and from various models of ageing in order to create a large-scale data-driven analysis and prediction platform for experimental interventions in gerontology.
The project involves both computational aspects (data aggregation and processing, multidimensional data analysis, network-based methods, systems theory approaches, etc) as well as wet-lab experiments (some of the predicted interventions will be tested in vivo), with a highly multi-disciplinary team.
Candidates should be highly motivated, with a PhD (or studying for the PhD title) in a biology-related field. Students enrolling for PhD in the current year (Oct-Nov), will be considered eligible, however their contract will be conditioned by successful enrollment to the PhD program and the starting date of this job will have to postdate the date of their PhD starting date. Excellent English language skills are also required in our group. Competencies in gerontology (ageing research), molecular biology, genetics and or biochemistry will be considered an advantage.
Based on genetic predictions resulted from bioinformatics analyses which have been performed or are currently underway, the successful candidate, together with other members of the wet-lab team, will conduct lifespan assays to test the effect of multiple genetic interventions on longevity. The research assistant will also support the group in analyzing the results obtained and will collaborate with the rest of the team to refine the prediction algorithms. If predictions will be successful in extending worm lifespans, additional biochemistry and molecular biology experiments to investigate the exact mechanisms by which this is achieved will be performed.
As a research assistant, the candidate’s responsibility will be to:
- Collaborate with the rest of the team in selecting the best genetic mutants to be tested,
- Culture C. elegans and use molecular biology to create knockout or transgenic worms under the supervision of other senior members of the team,
- Carry out morphological analyses and record C. elegans behavior throughout their lives,
- Perform lifespan and healthspan assays,
- Investigate molecular mechanisms of ageing in various C. elegans mutants,
- Analyze and interpret results from wet-lab experiments,
- Publish and present results to the group, at scientific meetings and in scientific papers
While not the main focus of the post, being in an interdisciplinary team will also offer the successful candidate the opportunity to train in other fields than his/her own (e.g. gerontology, bioinformatics and systems biology).
The post will require the successful candidate to be able to present his/her work to the rest of the group and occasionally might also require him/her to attend and present at national and international meetings. Depending on the existing skill set and the candidate’s career goals, attendance to various training courses could also be available.
International team, multi-disciplinary academic environment
Ideal candidate should have a primary degree in a field that is relevant to biology (eg: biochemistry, pharmacology, etc).
Web site for additional job details
REQUIRED EDUCATION LEVELBiological sciences: Bachelor Degree or equivalentMedical sciences: Bachelor Degree or equivalent
REQUIRED LANGUAGESENGLISH: Good
Mandatory skill requirements:
- Work experience in a biology, biochemistry, chemistry or pharmacology-related field
- Being able/open to work in a multi-disciplinary team and in a fast-paced work environment
- Excelent ability to communicate (oral/written/presentations) and work well in a team
Optional but desirable skills (will be a plus but are not mandatory):
- Prior experience in working with nematodes
- Knowledge in genetics and experience with methods of molecular biology
- Experience with microscopy techniques
For eligibility, the job application must include the following documents:
- Request for job application (form can be found on our website)
- Curriculum Vitae
- Copy of diploma for highest academic grade achieved
- Letter of intent
- A minimum of two letters of recommendation
It should be noted, that upon succesful selection, the candidate might be required to provide additional documents (eg: copy of official ID, all academic diplomas, criminal records, etc) or autorized translations of these (if the official document language is not Romanian).
Job applications should be sent before 16:00, 28.09.2018, by e-mail at firstname.lastname@example.org or directly at the Institute of Biochemistry of the Romanian Academy, Bucharest, Splaiul Independentei, nr 296, sector 6, room 307 (Human resources), for the attention of Dr. Robi Tacutu. We estimate that job interviews will take place within the next week after the job deadline, at the Institute’s location (in special cases, skype interviews can also be arranged).
Job first posted on: 28.08.2018
EURAXESS offer ID: 335473