07/06/2018

Postdoc: Molecular and Cellular Biology Scientist for developing new therapeutic approach to neurodegenerative diseases

This job offer has expired


  • ORGANISATION/COMPANY
    Sociedad para el Avance Cientifico, Society for the Improvement of Science (SACSIS)
  • RESEARCH FIELD
    Medical sciencesMedicine
    Pharmacological sciencesPharmacy
  • RESEARCHER PROFILE
    Recognised Researcher (R2)
  • APPLICATION DEADLINE
    22/06/2018 00:00 - Europe/Brussels
  • LOCATION
    Spain › Alcala de Guadaira
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    40

SACSIS is selecting a competitive candidate for the associated unit Neurodeath in the Medicine faculty of the University of Castilla - La Mancha (UCLM)The project aims to establish a new therapeutic approach for cancer treatment in general and for glioblastoma (GBM)  in particular, a tumor for which there is no effective treatment. This new therapeutic approach will be based on the use of RNAi technology (more specifically siRNA) to knock down selected proteins involved in tumoural cell survival and proliferation making them more susceptible to anticancer drugs and/or radiation. The specific siRNAs will be target-delivered by new multitasking nanoparticles that will be fine-tuned in their structure and chemical surface to perform efficiently the tasks required for targeting an intracerebral GBM xenograft like blood brain barrier crossing, siRNA target-delivered or tumor imaging. There are several relevant issues that are addressed by the project: a) Improving BBB crossing by nanoparticles;  b) toxicity of the nanoparticles in vivo and in vitro on healthy and tumoural cells; c) fine tuning of the 3D structure of the nanoparticles based on feed-back from biological experiments and d) the use of selected fresh xenografted human tumors obtained from cells isolated from patients to increase the likeliness that the response of the mice to the nanoplexes could enhance our understanding of key aspects of GBM biology and, in proper time, reach the clinical setting. The project will use a multidisciplinary approach strategy and most of  the techniques that are going to be used in the project are routinely  used by our group. The final result of the development of the project will be to provide the “proof-of-concept” in an animal model of xenografted human GBM cells, obtained from GBM patients, that RNAi therapeutics is effective in cancer treatment either by itself or by potentiating the effect of antitumoural drugs.

Benefits

  • Competitive candidates will be selected for applying to a Marie Curie IF grant that covers full salary (4.650€/month) + family allowance (500€/month) + R&D expenses.
  • High motivation and ability to be involved in an international multidisciplinary team. Mobility experience, participation in research projects and scientific productivity is appreciated.
  • Selected candidate will be mentored and trained for applying to a Marie Sklodowska Curie IF grant.

Eligibility criteria

  • Most fitting profile (expertise) for the described project.
  • Mobility rule: Researchers must not have resided or carried out their main activity (work, studies, investigation, etc.) in Spain for more than 12 months in the 3 years immediately prior to the call deadline (14/09/2018).

Selection process

  • Send an email indicating the title of this offer
  • Open quest to select the best candidates
  • Documents needed to apply: CV + One page motivation letter is positively valued

Required Research Experiences

  • RESEARCH FIELD
    Biological sciencesBiology
  • YEARS OF RESEARCH EXPERIENCE
    4 - 10

Offer Requirements

  • REQUIRED LANGUAGES
    ENGLISH: Good

Skills/Qualifications

Research area expertise: Tumor biology; cell signaling

Specific Requirements

  • Most fitting profile (expertise) for the described project.
  • Mobility rule: Researchers must not have resided or carried out their main activity (work, studies, investigation, etc.) in Spain for more than 12 months in the 3 years immediately prior to the call deadline (14/09/2018).

Work location(s)
1 position(s) available at
SACSIS
Spain
Sevilla
Alcala de Guadaira
41500
Calle Guatemala 1

EURAXESS offer ID: 313097

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