11/04/2018

Postdoctoral Fellow

This job offer has expired


  • ORGANISATION/COMPANY
    Jagiellonian University
  • RESEARCH FIELD
    Biological sciencesOther
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
  • APPLICATION DEADLINE
    12/05/2018 12:00 - Europe/Athens
  • LOCATION
    Poland › Kraków
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    40
  • OFFER STARTING DATE
    01/06/2018
  • REFERENCE NUMBER
    FNPostdoc3
  • IS THE JOB RELATED TO STAFF POSITION WITHIN A RESEARCH INFRASTRUCTURE?
    Yes

Project title: Merging Programmable DNA Nanorobots and Microfluidics for Orientationally Controlled Delivery of Membrane Proteins to Protocells

Project is carried out within the TEAM programme of the Foundation for Polish Science

Scientific discipline:

Droplet-based microfluidics, lipid chemistry, lipid biochemistry, molecular biology, biochemistry

Project description:

The successful candidate will join a project that aims to design and build novel DNA-based nanomachines able to interact with specific proteins and help construct artificial cells. The successful candidate will have the chance to carry out some work at the lab of collaborator Ilia Platzman at the Max Planck Institute, Germany.

Key responsibilities include:

  1. Contributing to protein and lipid novel nanostructure design.
  2. Structural studies of designed membrane protein complexes (using cryo-EM and AFM with expert collaborators and X-ray crystallography if applicable).
  3. Working with other members of the team to interact DNA devices with proteins and lipids
  4. Production and purification of proteins and liposomes and other lipid structures including separation and purification of modified GUVs and their downstream analyses
  5. Optimization of a microfluidics, GUV production system for interaction with DNA origami and designed proteins (with collaborator).
  6. Time-dependent measurement of the function of designed DNA/protein based nanomachines inside GUVs.
  7. Working with other members of the team to interact DNA devices with proteins and lipids

 

How to Apply

  1. Send applications to jonathan.heddle@uj.edu.pl applications should be marked “FNPostdoc3” and include the following:
  2. Copy of PhD certificate
  3. Contact details of a minimum of two referees including a former academic supervisor
  4. Motivation Letter
  5. CV
  6. Your application must include the following statement: “I hereby give consent for my personal data included in my application to be processed for the purposes of the recruitment process under the Personal Data Protection Act as of 29 August 1997, consolidated text: Journal of Laws 2016, item 922 as amended.”

Benefits

In the Heddle Lab we offer a dynamic and growing lab that is breaking new ground in bionanoscience and is extremely well-funded. We are housed in a new state-of the-art research centre with access to the full suite of equipment necessary for bionanoscience, biochemistry and structural biology research and work with a network of international collaborators in Europe and beyond including the chance for the candidate to interact with the renowned Max Planck Institute for Medical Research in Heidelberg Germany.

 

In addition, we offer:

 

i) Postdoctoral research position with generous, internationally competitive remuneration: 

 

ii) Discounted membership of sports facilities (“Multisport”, https://www.benefitsystems.pl/en/for-you/multisport/)

Subsidised social events (theatre tickets, hotels etc);

 

iii) Excellent training: In our diverse group you will be able to network with international researchers, experience and learn new skills including in DNA origami design, enzyme biochemistry, structural biology, protein design etc.

Offer Requirements

  • REQUIRED EDUCATION LEVEL
    Biological sciences: PhD or equivalent
    Chemistry: PhD or equivalent
  • REQUIRED LANGUAGES
    ENGLISH: Good

Skills/Qualifications

 

  1. Should have a PhD in chemical engineering, structural biology, molecular biology, biochemistry, biophysics or related discipline
  2. Must be less than 5 years since awarding of PhD (not including allowed career breaks)

  3. Experience working with lipids/membrane proteins/DNA nanostructures would be advantageous but not obligatory as these skills can be learned in-house 

  4. Experience in structural biology, particularly cryo EM will be advantageous but not obligatory
  5. Should have general molecular biology skills such as cloning and protein production/purification
  6. Have good skills of work management and experimental record keeping
  7. Should be able to work well in a multidisciplinary team
  8. Have good written and oral communication skills in English

 

Work location(s)
1 position(s) available at
Jagiellonian University
Poland
Kraków
30-387
Gronostajowa 7A

EURAXESS offer ID: 296727