30/03/2018

PhD in chemical biology in Marseille, France. Mechanistic studies of hydrogenases. Biochemistry, physical chemistry.


  • ORGANISATION/COMPANY
    CNRS / Aix Marseille University
  • RESEARCH FIELD
    ChemistryBiochemistry
    ChemistryInorganic chemistry
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
  • APPLICATION DEADLINE
    30/06/2018 00:00 - Europe/London
  • LOCATION
    France › Marseille
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    35
  • OFFER STARTING DATE
    01/10/2018

Our group (www.bip.cnrs-mrs.fr/bip06) investigates the function and maturation of various metalloenzymes. This project is concerned with “FeFe hydrogenases”, which oxidize and produce H2. They are studied in various contexts ranging from fundamental catalysis to the design of biofuel cells. We are interested in all steps in their catalytic mechanisms: long distance electron transfer, active site chemistry, reaction with inhibitors such as O2, interaction with light. We seek to understand the molecular basis of some of the global properties of redox enzymes, including catalytic bias and resistance to chemical stress. We have developed new methodologies that make it possible to use electrochemistry for studying certain steps in the catalytic mechanism that may be difficult to probe using conventional techniques, such as diffusion along the gas channels.

The PhD student will use direct electrochemistry and other kinetic methods to study various aspects of the reactivity of FeFe hydrogenases produced in our lab and by various collaborators. The project focuses on the molecular aspects of catalysis, using an interdisciplinary collaboration with biochemists/molecular biologists, spectroscopists and theoretical chemists.

Net salary (before tax): 1400€/months, for three years

The position is funded by A*MIDEX Foundation, and will start in september/october 2018.

Bibliography:

  • M. del Barrio, M. Sensi, C. Orain, C. Baffert, S. Dementin, V. Fourmond and C. Leger, “Electrochemical investigations of hydrogenases and other enzymes that produce and use solar fuels” Acc. Chem. Res., 2018, 51 (3), pp 769–777 (2018). doi:10.1021/acs.accounts.7b00622

  • M Sensi, M del Barrio, C Baffert, V Fourmond, C Leger “New perspectives in hydrogenase direct electrochemistry”, Current Opinion in Electrochemistry Volume 5, Issue 1, October 2017, Pages 135-145 (2017) doi:10.1016/j.coelec.2017.08.005

  • http://bip.cnrs-mrs.fr/bip06/publications.html

Selection process

To apply, please send to christophe.leger@imm.cnrs.fr a CV and the contact details of two former advisors, by June 30th, 2018.

Offer Requirements

  • REQUIRED EDUCATION LEVEL
    Chemistry: Master Degree or equivalent
    Biological sciences: Master Degree or equivalent
  • REQUIRED LANGUAGES
    ENGLISH: Good

Skills/Qualifications

The candidate will have a background in physical chemistry or biochemistry.  

Specific Requirements

The candidate will be interested in the pluridisciplinary approach that we develop. She/he will be interested in one or more of the following topics: enzyme mechanisms, structure function relationships, electrochemistry, kinetic modelling. 

A good level of English is required; speaking French may be useful but it is not required.

Map Information

Job Work Location Personal Assistance locations
Work location(s)
1 position(s) available at
CNRS / Aix Marseille University
France
Marseille
13009
31 ch. Joseph Aiguier

EURAXESS offer ID: 293685