ORGANISATION/COMPANYCNRS / Aix Marseille University
RESEARCH FIELDChemistry › BiochemistryChemistry › Inorganic chemistry
RESEARCHER PROFILEFirst Stage Researcher (R1)
APPLICATION DEADLINE30/06/2018 00:00 - Europe/London
LOCATIONFrance › Marseille
TYPE OF CONTRACTTemporary
HOURS PER WEEK35
OFFER STARTING DATE01/10/2018
Our group (www.bip.cnrs-mrs.fr/bip06) investigates the function and maturation of various metalloenzymes. This project is concerned with “FeFe hydrogenases”, which oxidize and produce H2. They are studied in various contexts ranging from fundamental catalysis to the design of biofuel cells. We are interested in all steps in their catalytic mechanisms: long distance electron transfer, active site chemistry, reaction with inhibitors such as O2, interaction with light. We seek to understand the molecular basis of some of the global properties of redox enzymes, including catalytic bias and resistance to chemical stress. We have developed new methodologies that make it possible to use electrochemistry for studying certain steps in the catalytic mechanism that may be difficult to probe using conventional techniques, such as diffusion along the gas channels.
The PhD student will use direct electrochemistry and other kinetic methods to study various aspects of the reactivity of FeFe hydrogenases produced in our lab and by various collaborators. The project focuses on the molecular aspects of catalysis, using an interdisciplinary collaboration with biochemists/molecular biologists, spectroscopists and theoretical chemists.
Net salary (before tax): 1400€/months, for three years.
The position is funded by A*MIDEX Foundation, and will start in september/october 2018.
M. del Barrio, M. Sensi, C. Orain, C. Baffert, S. Dementin, V. Fourmond and C. Leger, “Electrochemical investigations of hydrogenases and other enzymes that produce and use solar fuels” Acc. Chem. Res., 2018, 51 (3), pp 769–777 (2018). doi:10.1021/acs.accounts.7b00622
M Sensi, M del Barrio, C Baffert, V Fourmond, C Leger “New perspectives in hydrogenase direct electrochemistry”, Current Opinion in Electrochemistry Volume 5, Issue 1, October 2017, Pages 135-145 (2017) doi:10.1016/j.coelec.2017.08.005
REQUIRED EDUCATION LEVELChemistry: Master Degree or equivalentBiological sciences: Master Degree or equivalent
REQUIRED LANGUAGESENGLISH: Good
The candidate will have a background in physical chemistry or biochemistry.
The candidate will be interested in the pluridisciplinary approach that we develop. She/he will be interested in one or more of the following topics: enzyme mechanisms, structure function relationships, electrochemistry, kinetic modelling.
A good level of English is required; speaking French may be useful but it is not required.
EURAXESS offer ID: 293685
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