27/03/2018
Marie Skłodowska-Curie Actions

PhD in Molecular profiling in tumour tissue at single cell resolution for biomarker discovery

This job offer has expired


  • ORGANISATION/COMPANY
    Stockholm University
  • RESEARCH FIELD
    TechnologyBiotechnology
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
  • APPLICATION DEADLINE
    27/04/2018 18:00 - Europe/Brussels
  • LOCATION
    Sweden › Stockholm
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    40
  • OFFER STARTING DATE
    01/06/2018
  • EU RESEARCH FRAMEWORK PROGRAMME
    H2020 / Marie Skłodowska-Curie Actions
  • MARIE CURIE GRANT AGREEMENT NUMBER
    764281

In the framework of the European collaborative project AiPBAND (An Integrated Platform for Developing Brain Cancer Diagnostic Techniques) under Marie Skłodowska-Curie Actions, Stockholm University (Sweden) is recruiting one Early Stage Researcher (ESR). This ESR will be enrolled in the AiPBAND Innovative Training Network programme in which a group of early stage researchers will be exposed to the full breadth of disciplines associated with a new generation of biosensing techniques and diagnostic systems that can provide diagnosis, prognosis and monitoring of brain cancer, from both the academic and non-academic sectors. Through a set of synergistic research projects in gliomas diagnosis, targeting the most important and urgent clinical needs, the ESRs are offered a holistic training program, preparing them to be lead players in the field.

The specific research project offered by Stockholm University comprises the development of assays and methods for tissue profiling in clinical brain specimens. The work will be based on spatially resolved gene expression analysis of brain tissue for biomarker discovery and validation of biomarkers in blood. The project involves development of assays based on established in situ next generation sequencing (NGS) technology, allowing highly multiplexed biomarker analysis at single cell resolution in sections of formalin fixed paraffin embedded (FFPE) tissues from gliomas and generating biomarkers based on both cellular and molecular profiling. The technology is specific and sensitive enough to record even point mutations, and works well for mRNA profiling in tissues. The project will aim for the development of in situ NGS technology for miRNA profiling and protein profiling in FFPE tissue sections. The project will also involve intensive high resolution fluorescence microscopy and image analysis modules. The biomarkers will guide the development of assays for blood-based sensors. The ESR will work closely with clinical oncologists/pathologists in London and Rome.

Benefits

What we offer

  • An exciting project in a multicultural environment.
  • Being part of a multidisciplinary group of early stage researchers through the AiPBAND program. In total 14 researchers in various research institutes throughout Europe will be part of this program, each investigating a major hurdle in current diagnostic developments.
  • The opportunity to obtain a PhD. At the start of the project, a personal mentor will be assigned and a personalized career development plan will be jointly developed.
  • An extensive network-wide training program through the AiPBAND project, consisting of workshops, lectures, summer schools, webinars on project progress and web lessons on clinical research topics.

Eligibility criteria

  • Candidates shall, at the time of recruitment be in the first four years (full-time equivalent research experience) of their research careers and have not been awarded a doctoral degree.
  • Mobility rule: at the time of recruitment, researchers must not have resided or carried out their main activity (work, studies, etc.) in Sweden for more than 12 months in the last 3 years immediately prior to the reference date.
  • Strong and proven knowledge of the English language.

Selection process

  • Initial screening based on CV and letter
  • Interview(s) with selection committee
  • Approval by the AiPBAND Supervisory Board

Selections will be made regardless of gender, nationality, religion, ethnicity and cultural background, but aiming for a good balance among the group.

Additional comments

Place of employment

How to apply?

Please apply by e-mail (motivational letter / statement of purpose and CV in English) to mats.nilsson@scilifelab.se

Deadline for receiving the applications: 27th April 2018, 18:00 Stockholm Time (CET or GMT+1)

Anticipated start date: 1st June 2018

Web site for additional job details

Required Research Experiences

  • RESEARCH FIELD
    Biological sciencesBiology
  • YEARS OF RESEARCH EXPERIENCE
    1 - 4

Offer Requirements

  • REQUIRED EDUCATION LEVEL
    Biological sciences: Master Degree or equivalent
    Engineering: Master Degree or equivalent
    Neurosciences: Master Degree or equivalent
  • REQUIRED LANGUAGES
    ENGLISH: Excellent

Skills/Qualifications

The candidate should possess a Master degree in any of the following areas,

(i) A degree in the following or related Natural Sciences - Biology / Biochemistry / Molecular Biology (OR)

(ii) An engineering degree in any of the following or related fields - Bioengineering / Biotechnology / Biomedical Engineering, with previous hands-on experience with tools and techniques in molecular biology (OR)

(iii) Computational Biology / Bioinformatics / Biostatistics

    Specific Requirements

    The following desired qualifications would be advantageous:

    • Previous work experience with standard molecular biology techniques.
    • Experience with in situ hybridization, immunohistochemistry or similar tissue analysis techniques shall be advantageous.
    • Knowledge in bio-imaging and image analysis tools (like CellProfiler, ImageJ) shall be advantageous.
    • Highly motivated person with an interest to work in an inter-disciplinary area, ability to work in a team and collaborate, and capacity for analytical thinking and creativity desired.
    • Willingness to travel.
    • We look for scientific expertise and curiosity, as well as strong personal characteristics.

    Work location(s)
    1 position(s) available at
    Science for Life Laboratory
    Sweden
    Solna
    Stockholm
    17165
    Tomtebodavägen 23A

    Open, Transparent, Merit based Recruitment procedures of Researchers (OTM-R)

    Know more about it at SciLifeLab-SU-MolDia

    Know more about OTM-R

    EURAXESS offer ID: 292514