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How to build a biological decoder – dissecting calcium specificity in plants (MILLERB_U18SF)

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    University of East Anglia
    Biological sciences
    First Stage Researcher (R1)
    31/05/2018 23:00 - Europe/London
    United Kingdom › Norwich

Calcium is one of the most common secondary messengers involved in cell signalling in plants. A first response to a vast array of abiotic and biotic stresses includes changes in cytosolic calcium concentrations that regulate downstream processes. That so many processes seem to be governed by the change in the concentration of calcium has given rise to what has been called the calcium specificity problem: how can one ion species be responsible for conveying such diverse developmental processes and differentially active different pathways?

The aim of this PhD project is to develop a deeper understanding of how calcium signals are interpreted by cells and decoded into specific biological responses in plants. The project will focus on the calcium-dependent protein kinase signalling network in the model plant Arabidopsis thaliana, and will study the mechanism by which calcium-dependent protein kinases are regulated by calcium and how this allows the decoding of specific calcium signals.

This project will combine molecular biology, biochemistry and mathematical modelling, and will provide the student with excellent opportunities for multi-disciplinary training in plant molecular genetics and biochemical techniques, as well as computational modelling approaches.

Funding Notes:
This PhD project is offered on a self-funding basis. It is open to applicants with funding or those applying to funding sources. Details of tuition fees can be found at http://www.uea.ac.uk/study/postgraduate/research-degrees/fees-and-funding.

A bench fee is also payable on top of the tuition fee to cover specialist equipment or laboratory costs required for the research. The amount charged annually will vary considerably depending on the nature of the project and applicants should contact the primary supervisor for further information about the fee associated with the project.

Selection process

Application deadline: 31 May 2018, please note applications are processed as soon as they are received and the project may be filled before the closing date, so early application is encouraged.

Offer Requirements

Specific Requirements

Acceptable first degree: Biological Sciences

The standard minimum entry requirement is 2:1.

Work location(s)
1 position(s) available at
University of East Anglia
United Kingdom
University of East Anglia, Norwich Research Park, Norwich

EURAXESS offer ID: 286399